Ionizable cationic lipid for RNA delivery
What are described are compounds of formula II. The compound of formula II consists of a compound in which R 1 and R 2 are both a linear alkyl consisting of 1 to 12 carbons, an alkenyl or alkynyl consisting of 2 to 12 carbons; L 1 and L 2 both consist of a linear alkylene or alkenylene consisting of 5 to 18 carbons; X is S; L 3 consists of a bond; R 3 consists of a linear or branched alkylene consisting of 1 to 6 carbons; and R 4 and R 5 are the same or different, each consisting of hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons; or a pharmaceutically acceptable salt thereof.
1. A compound of formula II
wherein
R 1 and R 2 both consist of a linear alkyl consisting of 1 to 12 carbons, an alkenyl or alkynyl consisting of 2 to 12 carbons,
L 1 and L 2 both consist of a linear alkylene or alkenylene consisting of 5 to 18 carbons,
X is S,
L 3 is a bond,
R 3 is a linear or branched alkylene consisting of 1 to 6 carbons, and
R 4 and R 5 are the same or different, each hydrogen or a linear or branched alkyl consisting of 1 to 6 carbons.
2. The compound of claim 1 , wherein L 1 and L 2 both consist of a linear alkylene consisting of five carbons.
3. The compound of claim 1 , wherein R 3 consists of ethylene or propylene.
4. The compound of claim 1 , wherein R 4 and R 5 are the same or different, each consisting of hydrogen, methyl, or ethyl.
5. The compound of claim 1 , wherein R 1 and R 2 both consist of a linear alkenyl consisting of ten carbons.
6. The compound of claim 1 , selected from the group consisting of a compound of formulas 1) to 12)