Methods and compositions comprising a C-terminal Bax peptide
In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an aspect, the invention relates to compositions and methods of permeabilizing the membranes of cancer cells or microbial cells.
1. A composition comprising a C-terminal B cell lymphoma-2 (Bcl-2)-associated X protein (Bax) peptide (CT20p peptide) and a pharmaceutically acceptable carrier, wherein the CT20p peptide consists of the amino acid sequence of SEQ ID NO: 1 or comprises the amino acid sequence of SEQ ID NO: 2, 3, or 4.
2. The composition of claim 1 , further comprising a nanoparticle.
3. The composition of claim 2 , wherein the nanoparticle is aminated.
4. The composition of claim 3 , wherein the nanoparticle is a polymeric nanoparticle.
5. The composition of claim 2 , wherein the nanoparticle is carboxylated.
6. The composition of claim 5 , wherein the nanoparticle is a hyperbranched polymeric (HBPE) nanoparticle.
7. The composition of claim 2 , wherein the CT20p peptide is encapsulated in the nanoparticle.
8. The composition of claim 1 , further comprising one or more therapeutic agents.
9. An isolated peptide comprising the amino acid sequence of SEQ ID NO: 2, 3, or 4.