Uses of ganaxolone
Absence epilepsy, a form of epilepsy characterized by nonconvulsive seizures, has proven to be refractive to conventional epilepsy therapies. It has been found that low doses of ganaxolone can be used to reduce absence seizures in subjects with absence epilepsy, particularly pediatric subjects. In addition, ganaxolone therapy is particularly useful in subjects with absence epilepsy characterized by a reduction in tonic inhibition. Low dose ganaxolone is also used to reduce sleep disruptions and to treat sleep disorders in subjects in need of such treatment.
1. A method of treating absence epilepsy in a mammalian subject in need thereof, comprising administering ganaxolone to the mammalian subject in an amount of 0.2 to 2 mg/kg per dose, wherein the mammalian subject has been diagnosed with absence epilepsy, wherein the epilepsy is characterized by a deficit in tonic inhibition.
2. The method of claim 1 , wherein the mammalian subject has a γ2R43Q mutation in the GABA A receptor.
3. The method of claim 1 , wherein the mammalian subject is a human pediatric subject.
4. The method of claim 3 , wherein the human pediatric subject with absence epilepsy is 1 to 18 years of age, and has an average weight of 10 to 80 kg and the dose of ganaxolone is 2 to 160 mg per administration.
5. The method of claim 1 , wherein the mammalian subject suffers from nonconvulsive seizures associated with loss of consciousness, glassy-eyed staring, spike and wave EEG discharges, or a combination thereof.
6. The method of claim 1 , wherein the mammalian subject is resistant to standard antiabsence drug therapy.