Method and apparatus for non-invasive detection of conditions such as lung cancer
A method of determining whether a subject is likely to have a condition includes measuring concentration levels of a plurality of target biomarkers in a sample obtained from the subject; comparing the measured concentration levels to respective reference concentration levels; in the event that the measured concentration level of at least one of the target biomarkers is less than its respective reference concentration level, and the measured concentration level of at least one of the target biomarkers is greater than its respective reference concentration level, providing an indication that the subject is likely to have the condition, and otherwise: providing an indication that the subject is unlikely to have the condition.
1. An automated computer-implemented method of rapidly detecting a combination of up- and down-regulated target biomarkers in a breath sample of an individual, the combination of target biomarkers being indicative of the presence of lung cancer, the method comprising:
providing a computer processor operative to determine whether the individual is likely to have lung cancer based on a concentration level for each of the target biomarkers, wherein the target biomarkers consist of isoprene, furan, ethyl alcohol, toluene and m-Cresol,
obtaining the breath sample from the individual,
emitting infrared light through the sample and measuring the infrared light absorbance values of the sample to detect the presence of the target biomarkers, the light absorbance values being indicative of the concentration level for each of the detected target biomarkers,
determining which of the detected target biomarkers has a concentration level that is less than a respective threshold reference infrared absorption value and which of the detected target biomarkers has a concentration level that is greater than its respective threshold reference value,
where the combination of target biomarkers having lower concentration levels and target biomarkers having greater concentration levels is indicative of the presence of lung cancer, and
displaying, at the computer processor, the indicated presence of lung cancer to the individual.
2. The method of claim 1 , wherein the target biomarkers that are down-regulated are isoprene and furan.
3. The method of claim 1 , wherein the target biomarkers that are up-regulated are ethyl alcohol, toluene, and m-Cresol.
4. The method of claim 1 , wherein the combination indicative of the presence of lung cancer consists of the detected concentration levels of isoprene and furan being less than their respective threshold reference values, and the detected concentration levels of ethyl alcohol, toluene and m-Cresol being greater than their respective threshold reference values.
5. The method of claim 1 , wherein the infrared light is emitted in a plurality of pulsed, discrete monochromatic frequencies.
6. An automated computer-implemented method of rapidly detecting a combination of up- and down-regulated target biomarkers in a breath sample of an individual, the combination of target biomarkers being indicative of the presence of lung cancer, the method comprising:
providing a computer processor operative to determine whether the individual is likely to have lung cancer based on a concentration level for each of the target biomarkers, wherein the target biomarkers consist of isoprene, furan, ethyl alcohol, toluene and m-Cresol,
obtaining the breath sample from the individual,
emitting infrared light through the sample and measuring the infrared light absorbance values of the sample to detect the presence of the target biomarkers, the light absorbance values being indicative of the concentration level for each of the detected target biomarkers,
determining which of the detected target biomarkers has a concentration level that is less than a respective threshold reference infrared absorption value and which of the detected target biomarkers has a concentration level that is greater than its respective threshold reference value, and
displaying, at the computer processor, the indicated presence of lung cancer to the individual,
wherein the combination indicative of the presence of lung cancer consists of the detected concentration levels of isoprene and furan being less than their respective threshold reference values, and the detected concentration levels of ethyl alcohol, toluene and m-Cresol being greater than their respective threshold reference values.