Peptides and compositions for prevention of cell adhesion and methods of using same

1. A method of inhibiting adhesion of a single cell organism to a surface, the method comprising contacting the single cell organism with a composition comprising a cyclized peptide consisting of a length of up to 35 amino acids and comprising a sequence selected from the group consisting of FDYDWY (SEQ ID NO: 2) and FNFDWY (SEQ ID NO: 5) or combinations thereof,

wherein the surface is in a medical device selected from the group consisting of artificial blood vessels, catheters and other devices for the removal or delivery of fluids to patients, artificial hearts, artificial kidneys, orthopedic pins, prosthetic joints, plates, urinary devices, ventricular or arterio-venous shunts, prostheses, breast implants, penile prostheses, vascular grafting prostheses, aneurysm repair devices, mechanical heart valves, artificial joints, artificial larynxes, otological implants, anastomotic devices, vascular catheter ports, vascular stents, clamps, embolic devices, wound drain tubes, ocular lenses, dental implants, hydrocephalus shunts, pacemakers and implantable defibrillators, needleless connectors, and voice prostheses.

2. The method of claim 1 , wherein the catheter is selected from the group consisting of urological tubes, biliary tubes, endotracheal tubes, peripherably insertable central venous catheters, dialysis catheters, long term tunneled central venous catheters, peripheral venous catheters, short term central venous catheters, arterial catheters, pulmonary catheters, Swan-Ganz catheters, urinary catheters, and peritoneal catheters.

3. The method of claim 1 , wherein the device is an ocular lens.

4. The method of claim 3 , wherein the peptide comprises FDYDWY (SEQ ID NO: 2) and has a length of up to 35 amino acids.

5. The method of claim 3 , wherein the peptide is cyclized via a linker attached to the C and N termini.

6. The method of claim 3 , wherein the composition is coated on to the surface of the device.

7. The method of claim 1 , wherein the peptide comprises FNFDWY (SEQ ID NO: 2) and has a length of up to 26 amino acids.

8. The method of claim 1 , wherein the peptide comprises FDYDWY (SEQ ID NO: 2) and has a length of up to 35 amino acids.

9. The method of claim 1 , wherein the composition is coated on to the surface.

10. The method of claim 1 , wherein the composition is covalently attached to the surface.

11. The method of claim 1 , wherein the peptide comprises the sequence SFDYDWY (SEQ ID NO: 7).

12. The method of claim 1 , wherein the peptide comprises the sequence SFDYDWYN (SEQ ID NO: 8).

13. The method of claim 1 , wherein the peptide comprises the sequence HSFDYDWYN (SEQ ID NO: 9).

14. The method of claim 1 , wherein the peptide comprises the sequence HSFDYDWYNV (SEQ ID NO: 10).

15. The method of claim 1 , wherein the peptide comprises the sequence VHSFDYDWYNV (SEQ ID NO: 11).

16. The method of claim 1 , wherein the peptide comprises the sequence VHSFDYDWYNVS (SEQ ID NO: 12).

17. The method of claim 1 , wherein the peptide comprises the sequence SVHSFDYDWYNVS (SEQ ID NO: 13).

18. The method of claim 1 , wherein the peptide comprises the sequence SVHSFDYDWYNVSD (SEQ ID NO: 14).

19. The method of claim 1 , wherein the peptide comprises the sequence KSVHSFDYDWYNVSD (SEQ ID NO: 15).

20. The method of claim 1 , wherein the peptide comprises the sequence KSVHSFDYDWYNVSDQ (SEQ ID NO: 16).

21. The method of claim 1 , wherein the peptide comprises the sequence NKSVHSFDYDWYNVSDQ (SEQ ID NO: 17).

22. The method of claim 1 , wherein the peptide comprises the sequence NKSVHSFDYDWYNVSDQA (SEQ ID NO: 18).

23. The method of claim 1 , wherein the peptide comprises the sequence QNKSVHSFDYDWYNVSDQA (SEQ ID NO: 19).

24. The method of claim 1 , wherein the peptide comprises the sequence QNKSVHSFDYDWYNVSDQAD (SEQ ID NO: 20).

25. The method of claim 1 , wherein the peptide comprises the sequence SQNKSVHSFDYDWYNVSDQAD (SEQ ID NO: 21).

26. The method of claim 1 , wherein the peptide comprises the sequence SQNKSVHSFDYDWYNVSDQADL(SEQ ID NO: 22).

27. The method of claim 1 , wherein the peptide comprises the sequence FSQNKSVHSFDYDWYNVSDQADL (SEQ ID NO: 23).

28. The method of claim 1 , wherein the peptide comprises the sequence FSQNKSVHSFDYDWYNVSDQADLK (SEQ ID NO: 24).

29. The method of claim 1 , wherein the peptide comprises the sequence SFSQNKSVHSFDYDWYNVSDQADLK (SEQ ID NO: 25).

30. The method of claim 1 , wherein the peptide comprises the sequence SFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 3).

31. The method of claim 1 , wherein the peptide comprises the sequence CSFSQNKSVHSFDYDWYNVSDQADLKN (SEQ ID NO: 26).

32. The method of claim 1 , wherein the peptide comprises the sequence CSFSQNKSVHSFDYDWYNVSDQADLKNC (SEQ ID NO: 1).