Systems and methods for treating pulmonary edema
Various systems and methods are provided for treating pulmonary edema. In general, a pump can be configured to be implanted within a patient at risk of developing edema. The pump can be configured to pump fluid out of the patient's lungs, e.g., out of the patient's interstitial and alveolar spaces. The pump can be configured to be fully implanted within the patient's body. The pump can be configured to continuously pump fluid, or the pump can be configured to be selectively actuatable in response to a trigger event. In an exemplary embodiment, the pump can include an inflow port coupled to an inflow tube in fluid communication with a lymphatic vessel of the patient, and can include an outflow port coupled to an outflow tube in fluid communication with a vein of the patient.
1. A method of treating edema, comprising:
implanting a pump in a body of a patient, the pump being operable to convey a bodily fluid from an inflow port of the pump to an outflow port of the pump;
arranging a first tube having an inflow opening in fluid communication with the inflow port to be in fluid communication with a lymphatic duct of the patient;
arranging a second tube having an outflow opening and in fluid communication with the outflow port to be in fluid communication with a vein of the patient such that the pump is operable to convey fluid from the lymphatic duct to the vein and to create a low pressure zone adjacent to the lymphatic duct and between the inflow and outflow openings;
implanting a pressure sensor in the low pressure zone;
measuring pressure using the pressure sensor and activating the pump in response to the measured pressure exceeding a predefined threshold of at least 2 mm Hg at a junction of a subclavian vein and an internal jugular vein.
2. The method of claim 1 , further comprising actuating the pump, thereby causing the pump to convey the fluid from the lymphatic duct to the vein of the patient, the fluid including lymph.
3. The method of claim 1 , wherein the actuated pump maintains an outflow pressure in a range of 2 to 6 mmHg.
4. The method of claim 1 , wherein the pump is actuated in response to the measured pressure being above 6 mm Hg.
5. The method of claim 1 , wherein the pump is configured to be actuated periodically or continuously.
6. The method of claim 1 , wherein the vein includes one of the patient's subclavian vein, internal jugular vein, innominate vein, and superior vena cava.
7. The method of claim 1 , further comprising controlling a speed of operation of the pump depending on the measured pressure.
8. The method of claim 1 , wherein the pump is implanted adjacent to one of a junction of the patient's left subclavian vein and internal jugular vein and a junction of the patient's right subclavian vein and internal jugular vein.
9. The method of claim 1 , wherein the predefined threshold is at least 5 mm Hg at a junction of a subclavian vein and an internal jugular vein.
10. The method of claim 1 , wherein the predefined threshold is at least 6 mm Hg at a junction of a subclavian vein and an internal jugular vein.
11. The method of claim 1 , wherein the predefined threshold is at least 10 mm Hg at a junction of a subclavian vein and an internal jugular vein.