Compounds that inhibit human DNA ligases and methods of treating cancer
Methods for treating cancer using compounds that inhibit human DNA ligases. Methods for using compounds that inhibit human DNA ligases to provide insights into the reaction mechanisms of human DNA ligases, for example to identify the human DNA ligase involved in different DNA repair pathways. Screening methods for compounds that inhibit human DNA ligases.
1. A method of ameliorating neuroblastoma exhibiting an altered DNA damage response in a patient in need comprising administering to said patient an effective amount of an anti-cancer compound according to the chemical structure as set forth below:
in combination with a second cancer treatment comprising a DNA damaging agent.
2. The method according to claim 1 wherein said DNA damaging agent is ionizing radiation, a PARP inhibitor or a DNA alkylating agent.
3. The method according to claim 2 wherein said DNA damaging agent is a PARP inhibitor.
4. The method according to claim 3 wherein said PARP inhibitor is 3-aminobenzamide.
5. The method of claim 1 , wherein said DNA damaging agent is administered at the same time as administering said compound.
6. The method of claim 1 , wherein said DNA damaging agent is administered prior to administering said at least one compound.
7. The method of claim 1 , wherein said DNA damaging agent is administered after administering said at least one compound.