BLUE-GREEN ALGAE EXTRACT MIXTURES AND METHODS OF USE
Disclosed herein are compositions including a mixture of an aqueous extract of Aphanizomenon flos aquae and an aqueous extract of Arthrospira . The compositions are of use for inducing stem cell trafficking (such as stem cell mobilization and homing) in a subject. Thus, methods for increasing stem cell trafficking that include administering a effective amount of the mixture of the aqueous extract of Aphanizomenon fibs aquae and the aqueous extract of Arthrospira , are disclosed herein.
1 . A composition, comprising a first component and a second component, wherein:
the first component comprises an aqueous extract of Arthrospira ; and
the second component comprises an aqueous extract of Aphanizomenon flos aquae.
2 . The composition of claim 1 , wherein
(a) the aqueous extract of Arthrospira comprises an aqueous extract of fresh, dehydrated, or preserved Arthrospira;
(b) the aqueous extract of Aphanizomenon flos aquae comprises an aqueous extract of fresh, dehydrated, or preserved Aphanizomenon flos aquae ; or
(c) both (a) and (b).
3 . The composition of claim 1 , wherein
(a) the first component consists of a dried form of the aqueous extract Arthrospira ; and
(b) the second component consists of a dried form of the aqueous extract of fresh, dehydrated, or preserved Aphanizomenon flos aquae ; or
(c) both (a) and (b).
4 . The composition of claim 1 , wherein the first component and the second component are mixed at a ratio of about 10:90 w/w to about 90:10 w/w.
5 . The composition of claim 1 , wherein the first component and the second component are mixed at a ratio selected from the group consisting of about 5:95 w/w, about 10:90 w/w, about 20:80 w/w, about 30:70 w/w, about 40:60 w/w, about 50:50 w/w, about 60:40 w/w, about 70:30 w/w, about 80:20 w/w, about 90:10 w/w, and about 95:5 w/w.
6 . The composition of claim 1 , wherein the Arthrospira comprises Arthrospira platensis, Arthrospira maxima , or both.
7 . The composition of claim 1 , wherein the aqueous extract is a water extract or a buffered saline extract.
8 . The composition of claim 1 , comprising about 0.5 grams to about 5 grams of the mixture of the first and second components.
9 . The composition of claim 8 , where in the composition comprises about 0.5 grams of the first component and about 0.5 grams of the second component.
10 . The composition of claim 1 , wherein the composition is a solid.
11 . The composition of claim 10 , wherein the solid is encapsulated.
12 . A liquid composition, comprising the composition of claim 1 dissolved in water.
13 . A composition comprising a therapeutically effective amount of the composition of claim 1 in a pharmacologically acceptable carrier.
14 . A method of increasing stem cell trafficking in a subject, comprising:
administering to the subject a therapeutically effective amount of the composition of claim 1 , thereby increasing stem cell trafficking in the subject.
15 . The method of claim 14 , wherein the subject is a mammal.
16 . The method of claim 15 , wherein the subject is a human.
17 . The method of claim 14 , wherein increasing stem cell trafficking comprises an increase in the number of circulating stem cells in the subject.
18 . The method of claim 14 , wherein the stem cell is an endothelial stem cell.
19 . The method of claim 18 , wherein the stem cell is a CD45−CD31+KDR+ stem cell.
20 . The method of claim 19 , further comprising measuring CD45−CD31+KDR+ stem cells in the subject.
21 . The method of claim 14 , wherein the stem cell is a hematopoietic stem cell.
22 . The method of claim 21 , wherein the stem cell is a CD34+ stem cell.
23 . The method of claim 22 , further comprising measuring CD34+ stem cells in the subject.
24 . The method of claim 14 , wherein increasing stem cell trafficking comprises an increase in stem cell mobilization and/or homing of about 50% to about 500% in the subject as compared to a control.
25 . The method of claim 14 , wherein the subject is a healthy subject, or is a subject with a chronic illness, traumatic injury, osteoporosis, Alzheimer's disease, cardiac infarction, Parkinson's disease, traumatic brain injury, multiple sclerosis, cirrhosis of the liver, a digestive system disorder, a nervous system disorder, a lymph system disorder, cardiovascular system disorder, an endocrine system disorder, a degenerative disease, or is immunosuppressed.