Pyrazolopyridazines and methods for treating retinal-degenerative diseases and hearing loss associated with Usher syndrome
Compounds, compositions and methods for the treatment of retinal degenerative diseases, such as retinitis pigmentosa, Leber's congenital Amaurosis, Syndromic retinal degenerations, age-related macular degeneration and Usher Syndrome, and hearing loss associated with Usher Syndrome are described herein.
1. A method for treating a retinal degenerative disease, comprising administering to a subject in need thereof an effective amount of a compound having the structure
22:
or 23:
or a pharmaceutically acceptable salt thereof.
2. A method for treating hearing loss associated with Usher syndrome, comprising administering to a subject in need thereof an effective amount of a compound having the structure
22:
or 23:
or a pharmaceutically acceptable salt thereof.