Interventional drug delivery system and associated methods
A delivery system for local drug delivery to a target site of internal body tissue is provided. The delivery system comprises a source electrode adapted to be positioned proximate to a target site of internal body tissue. A counter electrode is in electrical communication with the source electrode, and is configured to cooperate with the source electrode to form a localized electric field proximate to the target site. A reservoir is configured to be disposed such that the reservoir is capable of interacting with the localized electric field. The reservoir is configured to carry a cargo capable of being delivered to the target site when exposed to the localized electric field. Associated methods are also provided.
1. A delivery system for local drug delivery through a target site of internal body tissue, the delivery system comprising:
a source electrode;
a counter electrode in electrical communication with the source electrode, the counter electrode being configured to cooperate with the source electrode to form a localized electric field at the target site;
a cargo capable of being delivered by iontophoresis into the tissue of the target site when exposed to the localized electric field formed between the source electrode and the counter electrode;
a surgically implantable housing comprising the source electrode and adapted to be secured to the target site, wherein the housing defines a reservoir to carry the cargo; and
a semi-permeable membrane sealing the reservoir for containing the cargo,
wherein the localized electric field formed between the source electrode and the counter electrode induces the cargo to permeate the membrane and transports the cargo through the membrane into the tissue; and
means for securing the housing to the tissue of the target site,
wherein the counter electrode is spaced from the housing and the source electrode, such that the source electrode and counter electrode are configured to receive tissue of the target site therebetween.
2. The delivery system as recited in claim 1 , wherein the housing defines an inlet and an outlet to the reservoir for flow of cargo into and out of the reservoir.
3. The delivery system as recited in claim 1 , wherein the cargo comprises at least one of nucleic acids, proteins, organic nanoparticles, therapeutic agents, and imaging agents.
4. The delivery system as recited in claim 1 , wherein the cargo comprises a therapeutic agent.
5. The delivery system as recited in claim 4 , wherein the therapeutic agent comprises gemcitabine.
6. The delivery system as recited in claim 1 , wherein the securing means comprises a plurality of anchor points defining suture openings.
7. The delivery system as recited in claim 1 , wherein the securing means comprises a biological adhesive.
8. The delivery system as recited in claim 1 , further comprising anion selective membrane surrounding the counter electrode.
9. The delivery system as recited in claim 1 , further comprising an electrode deployment device configured to insert at least one of the source electrode and the counter electrode proximate to the target site.
10. The delivery system as recited in claim 1 further comprising a coolant device operably engaged with the counter electrode, the coolant device being configured to provide cooling to the counter electrode.