PHARMACEUTICAL COMPOSITIONS
Pharmaceutical compositions are provided which comprise effective amounts of analgesic to treat a subject, including to reduce or eliminate an adverse effect associated with the analgesic.
1 - 22 . (canceled)
23 . A method for treating pain, the method comprising administering a solid oral dosage form to a subject in need thereof, wherein the solid oral dosage form comprises an immediate-release layer and a controlled-release layer, wherein the immediate-release layer comprises about 0.5-60 mg of promethazine or a pharmaceutical acceptable salt thereof and the controlled-release layer comprises an opioid analgesic and a non-opioid analgesic.
24 . The method of claim 23 , wherein the promethazine or a pharmaceutically acceptable salt thereof is present in an amount of about 12.5 mg.
25 . The method of claim 23 , wherein promethazine is present in an amount of about 11 mg.
26 . The method of claim 23 24 , wherein the pharmaceutically acceptable salt of the promethazine is promethazine hydrochloride and is present in an amount of about 12.5 mg.
27 . The method of claim 23 , wherein a pharmaceutically acceptable salt of the promethazine is promethazine hydrochloride.
28 . The method of claim 23 , wherein the opioid analgesic is hydrocodone, oxycodone, or a pharmaceutically acceptable salt thereof.
29 . The method of claim 28 , wherein the opioid analgesic is hydrocodone bitartrate.
30 . The method of claim 23 , wherein the non-opioid analgesic is acetaminophen or a pharmaceutically acceptable salt thereof.
31 . The method of claim 23 , wherein the solid oral dosage form is a bi-layer tablet.
32 . The method of claim 23 , wherein the pain is severe pain.
33 . A method for treating pain, the method comprising administering a solid oral dosage form to a subject in need thereof, wherein the solid oral dosage form comprises an immediate-release layer and a controlled-release layer, wherein the immediate-release layer comprises an antiemetic, and the controlled-release layer comprises a non-opioid analgesic and about 1-20 mg of hydrocodone, oxycodone, or a pharmaceutically acceptable salt thereof.
34 . The method of claim 33 , wherein the hydrocodone, oxycodone, or a pharmaceutically acceptable salt thereof is present in an amount of about 1 mg to about 15 mg.
35 . The method of claim 34 , wherein the hydrocodone or a pharmaceutically acceptable salt thereof is present in an amount of about 7.5 mg.
36 . The method of claim 34 , wherein the hydrocodone is present in an amount of about 5 mg.
37 . The method of claim 35 , wherein the pharmaceutically acceptable salt of the hydrocodone is hydrocodone bitartrate and is present in an amount of about 7.5 mg.
38 . The method of claim 34 , wherein the oxycodone or a pharmaceutically acceptable salt thereof is present in an amount of about 7.5 mg.
39 . The method of claim 33 , wherein a pharmaceutically acceptable salt of the hydrocodone is hydrocodone bitartrate.
40 . The method of claim 33 , wherein the antiemetic is promethazine or a pharmaceutically acceptable salt thereof.
41 . The method of claim 40 , wherein the antiemetic is promethazine hydrochloride.
42 . The method of claim 33 , wherein the non-opioid analgesic is acetaminophen or a pharmaceutically acceptable salt thereof.
43 . The method of claim 33 , wherein the solid oral dosage form is a bi-layer tablet.
44 . The method of claim 33 , wherein the pain is severe pain.
45 . A method for treating pain, the method comprising administering a solid oral dosage form to a subject in need thereof, wherein the solid oral dosage form comprises an immediate-release layer and a controlled-release layer, wherein the immediate-release layer comprises an antiemetic and the controlled-release layer comprises an opioid analgesic and about 200-600 mg of acetaminophen or a pharmaceutically acceptable salt thereof and an opioid analgesic.
46 . The method of claim 45 , wherein the acetaminophen or a pharmaceutically acceptable salt thereof is present in an amount of about 325 mg.
47 . The method of claim 45 , wherein the opioid analgesic is hydrocodone, oxycodone, or a pharmaceutically acceptable salt thereof.
48 . The method of claim 47 , wherein the opioid analgesic is hydrocodone bitartrate.
49 . The method of claim 45 , wherein the antiemetic is promethazine or a pharmaceutically acceptable salt thereof.
50 . The method of claim 49 , wherein the antiemetic is promethazine hydrochloride.
51 . The method of claim 45 , wherein the solid oral dosage form is a bi-layer tablet.
52 . The method of claim 45 , wherein the pain is severe pain.