RORgammaT inhibitors

1. A compound according to Formula I

or a pharmaceutically acceptable salt or solvate thereof, wherein

X is C(O),

Y is N;

n=0, 1, 2, 3 or 4;

A 4 is CR 4 , A 5 is CR 5 , A 6 is CR 6 , and A 7 is CR 7 ;

R 1 is (i) (C 3-7 )cycloalkyl or (C 3-5 )heterocycloalkyl, both optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, H 2 NC(O)—, (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, wherein (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl and (C 1-3 )alkoxy are optionally substituted with one or more halogens; (ii) (C 2-9 )heteroaryl, optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, H 2 NC(O)—, (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, wherein (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl and (C 1-3 )alkoxy are optionally substituted with one or more halogens; or

(iii) (C 6-14 )aryl, optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, H 2 NC(O)—, (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, wherein (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy are optionally substituted with one or more halogens;

R 2 is C(O)OH, 5-tetrazoylyl, HOC(CF 3 ) 2 , C(O)O(C 1-10 )alkyl, (C 1-10 )alkylsulfoxyaminocarbonyl; or carbamoyl;

R 3 is hydrogen, halogen, cyano, nitro, hydroxy, (C 1-3 )alkylC(O)O—, (C 1-4 )alkyl, or (C 1-4 )alkoxy, wherein (C 1-4 )alkyl and (C 1-4 )alkoxy are optionally substituted with one or more halogen;

R 4 -R 7 independently are H, halogen, amino, cyano, hydroxy, (C 1-3 )alkoxy, (C 1-4 )alkyl, (C 0-10 )alkyl)aminocarbonyl, (di)(C 1-6 )alkylaminocarbonyl or amino(C 1-4 )alkyl, wherein (C 1-3 )alkoxy, (C 1-4 )alkyl, (C 0-10 )alkyl)aminocarbonyl, (di)(C 1-6 )alkylaminocarbonyl and amino(C 1-4 )alkyl are optionally substituted with one or more halogen, hydroxyl or (C 1-3 )alkoxy; or a group having the formula

optionally substituted with one or more of the following: (C 1-10 )alkyl, halogen, amino, cyano, hydroxy, or (C 1-3 )alkoxy, and wherein m is 1, 2, 3, or 4.

2. A compound according to Formula Ia

or a pharmaceutically acceptable salt or solvate thereof, wherein

X represents C(O),

Y is N;

A 4 is CR 4 , A 5 is CR 5 , A 6 is CR 6 , and A 7 is CR 7 ;

R 1 is (C 3-7 )cycloalkyl or (C 3-5 )heterocycloalkyl, both optionally substituted with one or more groups selected from halogen, amino, cyano, hydroxy, H 2 NC(O)—, or (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, all optionally substituted with one or more halogens or;

R 1 is (C 2-9 )heteroaryl, optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, H 2 NC(O)—, or (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, all optionally substituted with one or more halogens or;

R 1 is (C 6-14 )aryl, optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, H 2 NC(O)—, or (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, all optionally substituted with one or more halogens;

R 2 is C(O)OH, 5-tetrazoylyl, or HOC(CF 3 ) 2 ;

R 3 is independently selected from hydrogen, halogen, cyano, nitro or (C 1-4 )alkyl, wherein the (C 1-4 )alkyl is optionally substituted with one or more halogens; and

R 4 -R 7 independently are H, halogen, amino, cyano, hydroxy, (C 1-3 )alkoxy, or (C 1-4 )-alkyl, wherein the (C 1-4 )alkyl is optionally substituted with one or more halogens.

3. The compound of claim 1 , wherein

R 1 is (i) (C 3-7 )cycloalkyl or (C 3-5 )heterocycloalkyl, both optionally substituted with one or more groups selected from (C 1-4 )alkyl or halogen; (ii) (C 2-9 )heteroaryl, optionally substituted with one or more groups selected from halogen, amino or (C 1-4 )alkyl; or (iii) (C 6-14 )aryl, optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, (C 1-3 )alkoxycarbonyl, (C 1-4 )alkyl, and (C 1-3 )alkoxy, wherein (C 1-3 )alkoxycarbonyl, (C 1-4 )alkyl and (C 1-3 )alkoxy are optionally substituted with one or more halogens.

4. The compound of claim 1 , wherein

R 1 is (C 2-9 )heteroaryl or (C 6-14 )aryl, both optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, (C 1-3 )alkoxycarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, wherein (C 1-3 )alkoxycarbonyl, (C 1-4 )alkyl and (C 1-3 )alkoxy are optionally substituted with one or more halogens.

5. The compound of claim 4 , wherein R 1 is phenyl, naphthyl, pyridinyl, quinolinyl, benzooxadiazolyl, thiophenyl, or isoxazolyl, each optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, (C 1-3 )alkoxycarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, wherein (C 1-3 )alkoxycarbonyl, (C 1-4 )alkyl and (C 1-3 )alkoxy are optionally substituted with one or more halogens.

6. The compound of claim 5 , wherein R 1 is phenyl, optionally substituted with one or more groups selected from halogen, amino, cyano, nitro, hydroxy, (C 1-3 )alkoxycarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, wherein (C 1-3 )alkoxycarbonyl, (C 1-4 )alkyl and (C 1-3 )alkoxy are optionally substituted with one or more halogens.

7. The compound of claim 6 , wherein R 2 is C(O)OH.

8. The compound of claim 1 having Formula Ib

or a pharmaceutically acceptable salt or solvate thereof.

9. The compound of claim 8 having Formula Ic

or a pharmaceutically acceptable salt or solvate thereof, wherein

X is C(O);

R 8 is selected from halogen, amino, cyano, nitro, hydroxy, H 2 NC(O)—, (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy, wherein (C 1-3 )alkoxycarbonyl, (di)(C 1-6 )alkylaminocarbonyl, (C 1-4 )alkyl or (C 1-3 )alkoxy are optionally substituted with one or more halogens; and

x is 0, 1, 2, 3, 4 or 5.

10. The compound of claim 9 having Formula Id

or a pharmaceutically acceptable salt or solvate thereof.

11. The compound of claim 10 having Formula Ie

or a pharmaceutically acceptable salt or solvate thereof.

12. A compound selected from:

4-(1-(2,6-dichlorobenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2,6-dichlorobenzoyl)-5-fluoro-1H-indazol-3-yl)benzoic acid;

4-(1-(2,6-dichlorobenzoyl)-7-fluoro-1H-indazol-3-yl)benzoic acid;

4-(1-(2,6-dichlorobenzoyl)-4-fluoro-1H-indazol-3-yl)benzoic acid;

4-(1-(2,6-dichlorobenzoyl)-6-fluoro-1H-indazol-3-yl)benzoic acid;

1,1,1,3,3,3-hexafluoro-2-(4-(1-(2-(trifluoromethyl)phenylsulfonyl)-1H-indazol-3-yl)phenyl)propan-2-ol;

4-(1-(2-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(3,5-dichloroisonicotinoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-bromobenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-(methoxycarbonyl)benzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(cyclohexanecarbonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-bromo-6-chlorobenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-fluoro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-fluoro-6-methoxybenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2,4,6-trichlorobenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2,6-dimethylbenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-ethoxybenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2,3-dichlorobenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chlorobenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-methyl-6-nitrobenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-(trifluoromethyl)phenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(quinolin-8-ylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-bromophenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2,5-dichlorophenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(3-chloro-2-methylphenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2,3-dichlorophenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2,3,4-trichlorophenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-cyanophenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-(trifluoromethoxy)phenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(naphthalen-1-ylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2,6-dichlorophenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-cyano-5-methylphenylsulfonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(3,5-dimethylphenylsulfonyl)-1H-indazol-3-yl)-2-(trifluoromethyl)benzoic acid;

3-(4-(1H-tetrazol-5-yl)phenyl)-1-(3-chlorophenylsulfonyl)-1H-indazole;

methyl 3-(3-(4-(1H-tetrazol-5-yl)phenyl)-1H-indazol-1-ylsulfonyl)thiophene-2-carboxylate;

3-(4-(1H-tetrazol-5-yl)phenyl)-1-(2-bromo-4-fluorophenylsulfonyl)-1H-indazole;

3-(4-(1H-tetrazol-5-yl)phenyl)-1-(3-bromo-5-chlorothiophen-2-ylsulfonyl)-1H-indazole;

4-(3-(4-(1H-tetrazol-5-yl)phenyl)-1H-indazol-1-ylsulfonyl)-3,5-dimethylisoxazole;

(3-(4-(1H-tetrazol-5-yl)phenyl)-1H-indazol-1-yl)(2,6-dichlorophenyl)methanone;

(3-(4-(1H-tetrazol-5-yl)phenyl)-1H-indazol-1-yl)(2,3-dichlorophenyl)methanone;

methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3-fluorobenzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3-fluorobenzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3-fluorobenzoate;

methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoate;

(2-chloro-6-(trifluoromethyl)phenyl)(4-fluoro-3-(4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl)-1H-indazol-1-yl)methanone;

3-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)benzoic acid;

2-(3-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)phenyl)acetic acid;

2-(4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)phenyl)acetic acid;

2-chloro-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)benzoic acid;

sodium 3-chloro-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)benzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)benzamide;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-fluoro-5-methylbenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3-methylbenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-methoxybenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-fluorobenzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-fluorobenzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-methylbenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3-methoxybenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2,6-difluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-isopropylbenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3,5-dimethoxybenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-cyano benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2,3-difluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2,5-difluorobenzoic acid;

2-chloro-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-5-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoic acid;

5-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-hydroxybenzoic acid;

3-fluoro-4-(4-fluoro-1-(2-fluoro-6-methoxybenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(4-fluoro-1-(2-fluoro-6-methoxybenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-(trifluoromethyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-isopropylbenzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-fluoro benzoate;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluoro benzoate;

3-chloro-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid;

3-fluoro-4-(1-(2-fluoro-6-methoxybenzoyl)-1H-indazol-3-yl)benzoic acid;

sodium 3-fluoro-4-(1-(2-fluoro-6-methoxybenzoyl)-1H-indazol-3-yl)benzoate;

4-(7-fluoro-1-(2-fluoro-6-methoxybenzoyl)-1H-indazol-3-yl)benzoic acid;

3-fluoro-4-(7-fluoro-1-(2-fluoro-6-methoxybenzoyl)-1H-indazol-3-yl)benzoic acid;

4-(6-bromo-1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl) benzoic acid;

4-(6-bromo-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-6-methoxy-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-hydroxy-1H-indazol-3-yl)benzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-hydroxy-1H-indazol-3-yl) benzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-hydroxy-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-6-hydroxy-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-6-hydroxy-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(hydroxymethyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(hydroxymethyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(methoxymethyl)-1H-indazol-3-yl)benzoic acid;

1-(2-chloro-6-(trifluoromethyl)benzoyl)-3-(4-(methoxy carbonyl)phenyl)-1H-indazole-6-carboxylic acid;

methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxyethylcarbamoyl)-1H-indazol-3-yl)benzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxy ethylcarbamoyl)-1H-indazol-3-yl)benzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxyethylcarbamoyl)-1H-indazol-3-yl)benzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxyethylcarbamoyl)-1H-indazol-3-yl)benzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxyethylcarbamoyl)-1H-indazol-3-yl)benzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)-3-fluorobenzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxyethylcarbamoyl)-1H-indazol-3-yl)-2-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxyethylcarbamoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)-2-fluorobenzoic acid;

3-chloro-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)benzoic acid;

3-chloro-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxyethylcarbamoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-hydroxypropylcarbamoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-hydroxypropylcarbamoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-methoxypropylcarbamoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(2-hydroxypropylcarbamoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(4-hydroxybutylcarbamoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-((2-hydroxyethyl)(methyl)carbamoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-((2-hydroxyethyl)(methyl)carbamoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-((2-methoxyethyl)(methyl)carbamoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3-fluoroazetidine-1-carbonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(3,3-difluoroazetidine-1-carbonyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(pyrrolidine-1-carbonyl)-1H-indazol-3-yl)benzoic acid;

4-(6-(azetidine-1-carbonyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-hydroxybenzoic acid;

2-acetoxy-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)benzoic acid;

sodium 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-hydroxybenzoate;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-fluoro-6-hydroxybenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3-hydroxybenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-3,6-difluoro-2-hydroxybenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-(dimethylcarbamoyl)-1H-indazol-3-yl)-2-hydroxybenzoic acid;

4-(6-(aminomethyl)-1-(2-chloro-6-(trifluoromethyl) benzoyl)-1H-indazol-3-yl)benzoic acid;

4-(6-(aminomethyl)-1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-(difluoro methyl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-6-cyano-1H-indazol-3-yl)benzoic acid;

3-chloro-4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)benzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-2-fluorobenzoic acid;

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-1H-indazol-3-yl)-3-fluorobenzoic acid;

and

4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-2-hydroxybenzoic acid; or

a pharmaceutically acceptable salt thereof.

13. A pharmaceutical composition comprising a compound of claim 1 and one or more pharmaceutically acceptable excipients.

14. A pharmaceutical composition comprising a compound of claim 12 and one or more pharmaceutically acceptable excipients.

15. The pharmaceutical composition of claim 13 , which further comprises at least one additional therapeutically active agent.

16. The pharmaceutical composition of claim 14 , which further comprises at least one additional therapeutically active agent.

17. A method for treating an autoimmune disease, comprising administering to a subject an effective amount of a compound of claim 1 to treat the autoimmune disease.

18. A method for treating a disease selected from multiple sclerosis, inflammatory bowel disease, Crohn's disease, psoriasis, rheumatoid arthritis, asthma, osteoarthritis, Kawasaki disease, Hashimoto's thyroiditis, and mucosal leishmaniasis, comprising administering to a subject an effective amount of a compound of claim 1 to treat the disease.

19. The compound of claim 2 , wherein R 4 -R 7 independently are hydrogen, halogen, or (C 1-4 )alkyl, wherein (C 1-4 )alkyl is optionally substituted with one or more halogens.

20. The compound of claim 19 , wherein R 1 is phenyl substituted with one or more groups selected from halogen, cyano, or (C 1-4 )alkyl, wherein (C 1-4 )alkyl is optionally substituted with one or more halogens; and R 2 is C(O)OH.