Granted Patent
B2
US 9,365,520 · App. 14/755,439 · Granted Jun 14, 2016
Heterocyclic compound
Inventors:
Satoshi Yamamoto (Kanagawa, JP); Junya Shirai (Kanagawa, JP); Tsuneo Oda (Kanagawa, JP); Mitsunori Kono (Kanagawa, JP); Atsuko Ochida (Kanagawa, JP); Takashi Imada (Kanagawa, JP); Hidekazu Tokuhara (Kanagawa, JP); Yoshihide Tomata (Kanagawa, JP); Naoki Ishii (Kanagawa, JP); Michiko Tawada (Kanagawa, JP); Yoshiyuki Fukase (New York, NY); Tomoya Yukawa (Kanagawa, JP); Shoji Fukumoto (Hyogo, JP)
Assignee:
Takeda Pharmaceutical Company Limited
C07D217/26A61K31/4375A61K31/472A61K31/4741C07D217/14C07D471/04C07D491/048C07D491/056C07D491/14C07F7/0812
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Abstract
The present invention provides a heterocyclic compound having a RORγt inhibitory action. The present invention relates to a compound represented by the formula (I): wherein each symbol is as defined in the specification. or a salt thereof.
Claims (2)
1. (cis-3-(((5R)-5-((7-Fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl)-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)carbonyl)cyclobutyl)acetic acid or a salt thereof.
2. A method of inhibiting RORγt in a mammal, which comprises administering an effective amount of the compound or salt of claim 1 to the mammal.
Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Oct 12, 2015
From: YAMAMOTO, SATOSHI; SHIRAI, JUNYA; ODA, TSUNEO; KONO, MITSUNORI; OCHIDA, ATSUKO; TOKUHARA, HIDEKAZU; IMADA, TAKASHI; TOMATA, YOSHIHIDE; ISHII, NAOKI; TAWADA, MICHIKO; FUKASE, YOSHIYUKI; YUKAWA, TOMOYA; FUKUMOTO, SHOJI
To: TAKEDA PHARMACEUTICAL COMPANY LIMITED
Reel/Frame 036773/0756 →
Priority Claims (2)
JP 2014-136359
· Jul 1, 2014
· national
JP 2014-262775
· Dec 25, 2014
· national
Continuity (1)