IP Library › Granted Patent US 10,350,216
Granted Patent B2
US 10,350,216 · App. 14/760,026 · Granted Jul 16, 2019

Methods of treating, preventing and diagnosing leukemia and other blood diseases and disorders

Inventor: Stavroula Kousteni (Glen Ridge, NJ)
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
A61K31/55A01K67/0276A61K39/3955A61K45/06C07K14/4702C07K16/18C07K16/22C07K16/28C07K16/2896C12Q1/6886G01N33/57426A01K2217/052A01K2217/075A01K2217/15A01K2217/206A01K2227/105A01K2267/03A01K2267/0331A61K2039/505A61K2039/804C07K16/30C07K16/3061C07K2317/73C07K2317/76C12Q2600/156C12Q2600/158G01N2333/4703
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Quick Facts
Patent No.
US 10,350,216
App. No.
14/760,026
Granted
Jul 16, 2019
Kind
B2
Abstract

The present invention relates to preventing and treating leukemia and diseases and disorders of the blood, by inhibiting canonical Wnt signaling in the osteoblasts. The inhibition is accomplished by blocking specific molecules and receptors in the pathway. The present invention also relates to a method of diagnosing leukemia and disorders of the blood, and methods and assay for drug screening and basic research.

Claims (4)

1. A method of treating and/or preventing acute myeloid leukemia (AML) and/or myelodysplastic syndrome (MDS), comprising administering to a subject in need thereof a therapeutically effective amount of an anti-Jagged-1 antibody.

2. The method of claim 1 , wherein the subject is a mammal.

3. The method of claim 1 , wherein the subject is a human.

4. The method of claim 1 , wherein the anti-Jagged-1 antibody inhibits the activation, expression and/or activity of Notch ligands in osteoblasts.

Assignments (2)
CONFIRMATORY LICENSE Recorded Sep 27, 2017
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 044030/0344 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 9, 2015
From: KOUSTENI, STAVROULA
To: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
Reel/Frame 036044/0739 →
Continuity (2)
Provisional Application 61752047 · Jan 14, 2013
Related Publication 20150359799A1 · Dec 17, 2015