IP Library Granted Patent US 11,654,125
Granted Patent B2
US 11,654,125 · App. 14/762,108 · Granted May 23, 2023

Agent for elevating nitric oxide concentration

Inventors: Masahiko Morita (Tokyo, JP); Ayako Kamimura (Tokyo, JP)
Assignee: KYOWA HAKKO BIO CO., LTD.
A61K31/198A61K38/063
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Quick Facts
Patent No.
US 11,654,125
App. No.
14/762,108
Granted
May 23, 2023
Kind
B2
Abstract

An agent for elevating nitric oxide (NO) concentration comprising glutathione or a salt thereof as an active ingredient; an agent for elevating NO concentration comprising glutathione or a salt thereof as an active ingredient for preventing or ameliorating a vascular endothelial malfunction-related symptom, or dilating blood vessels or promoting blood flow by elevating NO concentration; and a method for elevating NO concentration by ingesting glutathione or a salt thereof.

Claims (8)

1. A method for elevating nitric oxide (NO) concentration comprising orally administering glutathione or a salt thereof at a dose of 10 mg to 10 g per day to elevate the NO concentration of a subject who desires improvement in muscle metabolism, but does not have a vascular endothelial malfunction,

wherein the glutathione or a salt thereof is orally administered as a tablet, a powder, a granule, a pill, an infusion decoction, a capsule, a drink with glutathione dissolved therein, a drink with a salt of glutathione dissolved therein, a solution, an elixir, an extract, a tincture, or a fluid extract, and

wherein the elevated NO concentration causes muscle metabolism improvement in the subj ect.

2. A method for dilating blood vessels or promoting blood flow in a subject comprising orally administering glutathione or a salt thereof at a total dose of 10 mg to 10 g per day to dilate blood vessels or promote blood flow in a subject who desires improvement in muscle metabolism, but does not have a vascular endothelial malfunction,

wherein the glutathione or a salt thereof is orally administered as a tablet, a powder, a granule, a pill, an infusion decoction, a capsule, a drink with glutathione dissolved therein, a drink with a salt of glutathione dissolved therein, a solution, an elixir, an extract, a tincture, or a fluid extract, and

wherein the dilation of the blood vessels or promotion of blood flow causes muscle metabolism improvement in the subject.

3. The method for elevating NO concentration according to claim 1 , wherein the glutathione or a salt thereof is reduced glutathione or a salt thereof, or/and oxidized glutathione or a salt thereof.

4. The method for dilating blood vessels or promoting blood flow in a subject according to claim 2 , wherein the glutathione or a salt thereof is reduced glutathione or a salt thereof, or/and oxidized glutathione or a salt thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 21, 2015
From: MORITA, MASAHIKO; KAMIMURA, AYAKO
To: KYOWA HAKKO BIO CO., LTD.
Reel/Frame 036138/0724 →
Priority Claims (1)
JP JP2013-008239 · Jan 21, 2013 · national
Continuity (1)
Related Publication 20150352067A1 · Dec 10, 2015