Methods and devices for skin tightening
The present invention relates to methods and devices for skin tightening after incising or excising tissue portions from a subject. Exemplary methods and devices include tunable dressings having an adhesive layer and a regulatable layer or an un-stretched layer that responds to one or more external stimuli to contract or expand the dressing, where the contraction or expansion can be uniform or non-uniform.
1. A method of skin tightening comprising:
(i) affixing a tunable dressing to a skin region, wherein said dressing is configured, when applied to said skin region from which a plurality of incised tissue portions and/or excised tissue portions has been excised by an apparatus comprising one or more hollow needles for making incisions and/or excisions in a skin region to provide contraction or expansion of said skin region in one or more directions; and
(ii) adjusting said contraction or expansion by exposing said dressing to one or more external stimuli that result an increase in tension of said dressing, a decrease in tension of said dressing, an increase in compressive force exerted by said dressing, a decrease in compressive force exerted by said dressing, compression in one or more directions of said dressing, and/or expansion in one or more directions of said dressing,
wherein said dressing comprises (i) an adhesive layer and (ii) an unstretched layer that comprises one or more materials that are naïve materials in that they can be stretched in subsequent use, and
wherein an areal fraction of the skin region that has been excised is between 5% and 10%.
2. The method of claim 1 , wherein said adjusting step (ii) provides selectively closing or opening said incised tissue portions and/or excised tissue portions.
3. The method of claim 2 , wherein said adjusting step (ii) comprises adjusting said contraction or expansion across the entire dressing or a portion of said dressing.
4. The method of claim 3 , wherein said compression or expansion is non-uniform across said entire dressing or in a portion of said dressing.
5. The method of claim 1 , wherein at least two of said tissue portions has an areal dimension that is less than 1 mm 2 .
6. The method of claim 1 , wherein at least one of said tissue portions has at least one dimension that is less than 1 mm.
7. The method of claim 1 , wherein said plurality of incised tissue portions and/or excised tissue portions comprise one or more circular or elliptical holes in said skin region.
8. The method of claim 1 , wherein said affixing step (i) is performed within about ten seconds of incising and/or excising said skin region.
9. The method of claim 1 , wherein said method results in controlling pleating in said skin region.
10. The method of claim 1 , wherein the one or more external stimuli are selected from a group consisting of a change in temperature, pH, light, moisture, solvent, chemical exposure, electric field, and magnetic field.
11. The method of claim 1 , wherein said plurality of excised tissue portions comprise a fat layer.
12. The method of claim 1 , wherein said increase or decrease in tension or compressive force is an increase or decrease in the x-axis, y-axis, and/or z-axis of said dressing, as compared to before exposing said dressing to said one or more external stimuli.
13. The method of claim 1 , wherein said increase or decrease in tension or compressive force is an increase or decrease of intensity of at least 1% after exposure to said one or more external stimuli, as compared to before said exposure.
14. The method of claim 1 , wherein said increase or decrease in tension or compressive force occurs in a portion of said dressing.
15. The method of claim 1 , wherein said increase or decrease in tension or compressive force is non-uniform across the entire dressing or in a portion of said dressing.
16. The method of claim 1 , wherein said adhesive layer comprises a continuous layer of one or more adhesive materials or a discontinuous layer of one or more adhesive materials, wherein said adhesive layer results in said increase or decrease in tension or compressive force in said one or more adhesive materials in at least a portion of said dressing.
17. The method of claim 1 , wherein the dressing is characterized in that exposing said dressing to said one or more external stimuli results in an increase in permeability.
18. The method of claim 1 , wherein the dressing comprises a moisture absorption layer.
19. The method of claim 1 , wherein the dressing is porous.
20. The method of claim 1 , wherein the apparatus is a microablation tool.