Thromboresistant/bactericidal s-nitroso-n-acetylpenicillamine (SNAP)-doped nitric oxide release polymers with enhanced stability
A polymeric film includes a polymer matrix having at least one of a discrete RSNO adduct or a polymeric RSNO adduct associated therewith, by: covalent attachment to the polymer matrix; dispersion within the polymer matrix; or both, with the at least one of the discrete RSNO adduct or the polymeric RSNO adduct capable of releasing nitric oxide (NO). The polymer matrix is a polyurethane polymer matrix, a silicone rubber polymer matrix, or a copolymer matrix of polyurethane and silicone rubber. The polymeric film is to exhibit stability under dry conditions at 37° C. and prolonged and controllable NO release rates, when exposed to moisture or light capable of photolyzing an RSNO bond, for a predetermined amount of time from the at least one of the discrete RSNO adduct or the polymeric RSNO adduct.
1. A polymeric film, consisting of:
a polymer matrix; and
a discrete RSNO adduct introduced into the polymeric matrix;
wherein the discrete RSNO adduct is S-nitroso-N-acetylpenicillamine (SNAP) present in an amount ranging from about 5 wt % to about 10 wt % and includes SNAP crystals, wherein the discrete RSNO adduct is capable of releasing nitric oxide (NO), and wherein the polymer matrix is a polyurethane polymer matrix, a silicone rubber polymer matrix, a thermoplastic silicone-polycarbonate-urethane, a poly(vinyl chloride) polymer matrix, or a siloxane-based polyurethane elastomer;
the polymeric film to exhibit stability under dry conditions at 37° C. and controllable NO release rates over at least a 7 day period, when exposed to moisture or light capable of photolyzing an RSNO bond, from the discrete RSNO adduct.
2. The polymeric film as defined in claim 1 wherein the polymer matrix comprises a hydrophobic polymer selected from the group consisting of the silicone rubber having water uptake of 1.2 wt %±0.3, the thermoplastic silicone-polycarbonate-urethane having water uptake of 1.5 wt %±0.3, the siloxane-based polyurethane elastomer having water uptake of 1.2 wt %±0.1; and the polyurethane polymer having water uptake of 6.2 wt %±0.7.
3. The polymeric film as defined in claim 1 wherein:
the polymer matrix is the siloxane-based polyurethane elastomer;
the SNAP is present in an amount of about 10 wt %; and
wherein NO is released over at least 20 days.
4. The polymeric film as defined in claim 1 wherein the discrete RSNO adduct is dispersed within the polymer matrix, and wherein the discrete RSNO adduct is present in an amount of about 5 wt %.
5. The polymeric film as defined in claim 1 wherein the discrete RSNO adduct is dispersed within the polymer matrix, and wherein the discrete RSNO adduct is present in an amount of about 10 wt %.
6. A polymeric composition, comprising:
a base polymer layer;
a top polymer layer disposed on the base polymer layer; and
at least one active layer intermediate to the base polymer layer and the top polymer layer, and the at least one active intermediate layer including the polymeric film as defined in claim 3 .
7. The polymeric composition as defined in claim 6 wherein:
the base polymer layer is selected from a siloxane-based polyurethane elastomer, poly(vinyl chloride), crosslinked polyurethane, crosslinked silicone rubber, and polytetrafluoroethylene; and
the top polymer layer is a siloxane-based polyurethane elastomer, poly(vinyl chloride), crosslinked polyurethane, crosslinked silicone rubber, and polytetrafluoroethylene.
8. The polymeric film as defined in claim 1 wherein:
the polymer matrix is the siloxane-based polyurethane elastomer; and
the SNAP is present in an amount of about 5 wt %.
9. The polymeric film as defined in claim 4 wherein the polymer matrix is the siloxane-based polyurethane elastomer or the poly(vinyl chloride) polymer matrix.