Treatment of DNA damage and mitochondrial dysfunction using palm fruit juice
Methods, compositions and kits for the prevention and treatment of mitochondrial dysfunction, mitochondrial DNA damage and genomic DNA damage are provided. The methods use the administration of palm fruit juice and/or compositions containing phenolic compounds present in palm fruit juice. The methods, compositions, and kits can be used to reduce DNA damage in subjects being treated with nucleoside reverse transcriptase inhibitors, such as patients having HIV or AIDS.
1. A method of treating or preventing mitochondrial dysfunction in a subject who has been administered a nucleoside reverse transcriptase inhibitor (NRTI) or isoniazid, the method comprising administering to the subject a composition containing a water soluble extract from a fruit of genus Elaeis or one or more phenolic compounds present in a water soluble extract from a fruit of genus Elaeis.
2. A method of treating or preventing mtDNA damage in a subject who has been administered a nucleoside reverse transcriptase inhibitor (NRTI) or isoniazid, the method comprising administering to the subject a composition comprising a water soluble extract from a fruit of genus Elaeis or one or more phenolic compounds present in a water soluble extract from a fruit of genus Elaeis.
3. The method of claim 1 , further comprising administering an NRTI to the subject.
4. The method of claim 1 , wherein the NRTI is 3′-azido-3′-deoxythymidine (AZT).
5. The method of claim 1 , wherein the NRTI inhibits mitochondrial polymerase γ.
6. The method of claim 1 , wherein the NRTI increases the rate of mitochondrial DNA mutations.
7. The method of claim 1 , wherein administration of the composition comprising a water soluble extract from a fruit of genus Elaeis or one or more phenolic compounds present in a water soluble extract from a fruit of genus Elaeis decreases the rate of mitochondrial DNA mutations.
8. The method of claim 1 , wherein one or more phenolic compounds present in a water soluble extract from a fruit of genus Elaeis is administered, and said one or more phenolic compounds are natural or synthetic.
9. The method of claim 1 , further comprising determining whether the subject has a mitochondrial DNA mutation.