IP Library › Granted Patent US 9,744,108
Granted Patent B2
US 9,744,108 · App. 14/771,222 · Granted Aug 29, 2017

Methods and compositions for preventing and treating tooth erosion

Inventors: Mojdeh Dehghan (Germantown, TN); Daranee Versluis-Tantbirojn (Memphis, TN)
Assignee: University of Tennessee Research Foundation
A61K8/21A61K8/19A61K8/20A61K8/24A61K8/41A61K8/97A61Q11/00A61K2800/20
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Quick Facts
Patent No.
US 9,744,108
App. No.
14/771,222
Granted
Aug 29, 2017
Kind
B2
Abstract

Methods and compositions are provided for reducing, treating or preventing dental erosion in a patient in need of such treatment, the methods and compositions comprising administering a therapeutically effective amount of an alkalinizing agent and a re-mineralizing agent to the teeth. Dental erosion is a significant oral health problem that affects millions of individuals around the world. Erosive tooth wear can cause significant tooth damage compromising the esthetics and function of teeth, requiring extensive dental treatment.

Claims (8)

1. A method of treating erosion of the teeth in a patient in need of such treatment, the method comprising administering a first mouthwash comprising a therapeutically effective amount of an alkalinizing agent to the teeth so as to raise saliva pH to 7.0 or above; and administering a second mouthwash comprising a therapeutically effective amount of a re-mineralizing agent to the teeth, wherein the alkalinizing agent comprises sodium bicarbonate in an amount of about 0.5-5 wt %, calcium chloride in an amount of about 0.01-0.1 wt %, potassium phosphate in an amount of about 0.005-0.05 wt %, and arginine bicarbonate in an amount of about 1-8 wt %; and the re-mineralizing agent comprises casein phosphopeptide in an amount of about 0.1-10 wt %, and sodium fluoride in an amount of about 0.01-1 wt %.

2. A method according to claim 1 , wherein the alkalinizing agent further comprises (i) a re-hardening agent, (ii) eucalyptus, and (iii) licorice root.

3. A method according to claim 1 , wherein the pH of the saliva is 5 or below before the alkalinizing agent is applied to the teeth.

4. A method according to claim 1 , wherein the pH of the first mouthwash is at least 8.0.

5. A method according to claim 1 , wherein the first mouthwash is in a quantity of between about 15 mLs to about 60 mLs.

6. A method according to claim 1 , wherein the second mouthwash is in a quantity of between about 15 mLs to 60 mLs.

7. A method according to claim 1 , wherein the first mouthwash is applied to the teeth first and contacts the teeth for a time between about 20 and about 35 seconds; and then the second mouthwash is applied following the application of the first mouthwash and contacts the teeth for a time between about 20 and about 35 seconds.

8. A method according to claim 1 , wherein the alkalinizing agent further comprises eucalyptus oil and licorice root extract; and the re-mineralizing agent further comprises green tea extract.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 22, 2016
From: DEHGHAN, MOJDEH; VERSLUIS-TANTBIROJN, DARANEE
To: UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
Reel/Frame 037787/0593 →
Continuity (2)
Provisional Application 61770863 · Feb 28, 2013
Related Publication 20160000664A1 · Jan 7, 2016