Method for producing nanofibers capable of storing and transferring nitric oxide and nanofibers capable of storing and transferring nitric oxide produced thereby

1. A nanofiber capable of storing and transferring nitric oxide, which is produced by the method comprising:

a filling step for filling a first material with nitric oxide;

a synthesis step for synthesizing a second material having a —Si(OCH 3 ) 3 functional group capable of covalently bonding to the first material filled with nitric oxide to perform a sol-gel reaction;

a sol-gel reaction step for carrying out a sol-gel reaction of the first material filled with nitric oxide with the second material to form a gel of a network structure; and

an electrospinning step for using an electrospinning process to produce a nanofiber with the gel,

wherein the first material comprises a material having an amine functional group and an alkoxy group.

2. The nanofiber of claim 1 , wherein the first material comprises aminoalkoxysilane.

3. The nanofiber of claim 2 , wherein the aminoalkoxysilane comprises one or more selected from the group consisting of N-(6-aminohexyl) aminopropyltrimethoxysilane (AHAP3), N-(2-aminoethyl)-3-aminopropyltritnethoxysilane (AEAP3), N-(2-aminoethyl) aminophenethyltrimethoxysilane (AEMP3), (3-trimethoxysilylpropyl) diethylenetriamine (DET3), methylaminopropyltrimethoxysilane (MAP3), N-(acetylglycyl)-3-aminopropyltrimethoxysilane, N-(3-acryloxy-2-hydroxypropyl)-3-aminopropyltriethoxysilane, N-(2-aminoethyl)-3-aminoisobutylmethyldimethoxysilane, N-(2-aminoethyl)-3-aminopropylmethyldiethoxysilane, N-(2-aminoethyl)-3-aminopropylinethyldimethoxysilane, N-(2-aminoethyl)-3-aminopropylsilanetriol, N-(2-aminoethyl)-3-aminopropyitriethoxysilane, N-(6-aminohexyl)aminomethyltriethoxysilane, N-(2-aminoethyl)-11-aminoundecyltrimethoxysilane, N-[3-amino(polypropylenoxy)]aminopropyltrimethoxysilane, 3-aminopropylsilanetriol, N-(2-N-benzylamino ethyl)-3-aminopropyl trimethoxysilane hydrochloride, and a combination thereof.

4. The nanofiber of claim 1 , wherein the second material is a polymer capable of being electrospun.

5. The nanofiber of claim 1 , wherein the second material comprises one or more selected from the group consisting of polymethylmethacrylate (PMMA), nylon-6,6 (PA-6,6), polyurethanes (PU), polybenzimidazole (PBI), polycarbonate (PC), polyacrylonitrile (PAN), polyvinyl alcohol (PVA), polylactic acid (PLA), polyethylene-co-vinyl acetate (PEVA), polymethacrylate (PMA), polyethylene oxide (PEO), polyaniline (PANI), polyvinylcarbazole, polyethylene terephthalate (PET), polyacrylic acid-polypyrenemethanole (PAA-PM), polystyrene (PS), polyimide (PA), polyvinylphenol (PVP), polyvinylchloride (PVC), cellulose acetate (CA), polyacrylamide (PAAm), poly(lactic-co-glycolic acid) (PLGA), collagen, polycaprolactone (PCL), poly(2-hydroxyethyl methacrylate) (HEMA), poly(vinylidene fluoride) (PVDF), polyether imide (PEI), polyethylene glycol (PEG), nylon-4,6(PA-4,6), poly(ferrocenyldimethylsilane) (PFDMS), poly(ethylene-co-vinyl alcohol), polyvinyl pyrrolidone (PVP), polymetha-phenyleneisophthalamide, and a combination thereof.

6. The nanofiber of claim 1 , wherein the filling step is carried out by a process of dissolving the first material in a solvent, and then increasing the pressure of nitric oxide.

7. The nanofiber of claim 1 , wherein the sol-gel reaction is carried out at −10 to 30° C. and a pH of 5 to 10 for 1 to 6 hours.

8. The nanofiber of claim 1 , wherein the nanofiber comprises network structure formed by the sol-gel reaction of the first material filled with nitric oxide and the second material.

9. A method for producing nanofibers storing and transferring nitric oxide, the method comprising:

a filling step for filling a first material with nitric oxide;

a synthesis step for synthesizing a second material having a —Si(OCH 3 ) 3 functional group capable of covalently bonding to the first material filled with nitric oxide to perform a sol-gel reaction;

a sol-gel reaction step for carrying out a sol-gel reaction of the first material filled with nitric oxide with the second material to produce a gel of a network structure; and

an electrospinning step for using an electrospinning process to produce a nanofiber with the gel,

wherein the first material comprises a material having an amine functional group and an alkoxy group in the molecule.

10. The method of claim 9 , wherein the first material comprises aminoalkoxysilane.

11. The method of claim 10 , wherein the aminoalkoxysilane comprises one or more selected from the group consisting of N-(6-arninohexyl) aminapropyltrimethoxysilane (AHAP3), N-(2-aminoethyl)-3-arninopropyltrimethoxysilane (AEAP3), N-(2-aminoethyl) aminophenethyltrimethoxysilane (AEMP3), (3-trimethoxysilylpropyl) diethylenetriamine (DET3), methylaminopropyltrimethoxysilane (MAP3), N-(acetylglycyl)-3-arninopropyltrimethoxysilane, N-(3-acryloxy-2-hydroxypropyl)-3-aminopropyltriethoxysilane, N-(2-aminoethyl)-3-arninoisobutylmethyldimethoxysilane, N-(2-aminoethyl)-3-aminopropylmethykliethoxysilane, N-(2-aminoethyl)-3-aminopropylmethyldimethoxysilane, N-(2-aminoethyl)-3-aminopropylsilanetriol, N-(2-aminoethyl)-3-aminopropyltriethoxysilane, N-(6-aminohexyl) aminomethyltriethoxysilane, N-(2-aminoethyl)-11-aminoundecyltrimethoxysilane, N[3-amino(polypropylenoxy)]aminopropyltrimethoxysilane, 3-aminopropylsilanetriol, N-(2-N-benzylamino ethyl)-3-aminopropyl trimethoxysilane hydrochloride, and a combination thereof.

12. The method of claim 9 , wherein the second material is a polymer capable of being electrospun.

13. The method of claim 10 , wherein the second material comprises one or more selected from the group consisting of polymethylmethacrylate (PMMA), nylon-6,6 (PA-6,6), polyurethanes (PU), polybenzimidazole (PBI), polycarbonate (PC), polyacrylonitrile (PAN), polyvinyl alcohol (PVA), polylactic acid (PLA), polyethylene-co-vinyl acetate (PEVA), polymethacrylate (PMA), polyethylene oxide (PEO), polyaniline (PANI), polyvinylcarbazole, polyethylene terephthalate (PET), polyacrylic acid-polypyrenemethanole (PAA-PM), polystyrene (PS), polyamide (PA), polyvinylphenol (PVP), polyvinylchloride (PVC), cellulose acetate (CA), polyacrylamide (PAAm), poly(lactic-co-glycolic acid) (PLGA), collagen, polycaprolactone (PCL), poly(2-hydroxyethyl methacrylate) (HEMA), poly(vinylidene fluoride) (PVDF), polyether imide (PEI), polyethylene glycol (PEG), nylon-4,6 (PA-4,6), poly(ferrocenyldimethylsilane) (PFDMS), poly(ethylene-co-vinyl alcohol), polyvinyl pyrrolidone (PVP), polymetha-phenyleneisophthalamide, and a combination thereof.

14. The method of claim 11 , wherein the filling step is carried out by a process of dissolving the first material in a solvent, and then increasing the pressure of nitric oxide.

15. The method of claim 12 , wherein the sol-gel reaction is carried out at −10 to 30° C. and a pH of 5 to 10 for 1 to 6 hours.