Compounds for the treatment of tuberculosis
Disclosed are compounds that can be used for treating tuberculosis.
1. A method of treating tuberculosis comprising administering to a subject a pharmaceutical composition comprising a compound of Formula I-b, I-c, I-d, or I-e, or a pharmaceutically acceptable salt, ester or prodrug thereof:
wherein
R 3 is null, O, H, optionally substituted C 1 -C 6 linear or branched alkyl, or
R 4 is —C≡CH, —C≡C(CH 2 ) t OH, —O(CH 2 ) u CH 3 , —O(CH 2 ) q C(═O)O(CH 2 ) p CH 3 ,
optionally substituted C 1 -C 6 alkoxy, optionally substituted alkylamino, or C 3 -C 6 carbocycle;
R 5 is
and,
z is 1-6,
wherein
R 6 and R 10 are each independently H, halo, C 1 -C 6 linear or branched alkyl, C 1 -C 6 haloalkyl, cyano, C 1 -C 6 alkoxy, halogen substituted C 1 -C 6 alkoxy, OH, —O(CH 2 ) q C(═O)O(CH 2 ) p CH 3 , —O(CH 2 ) q C(═O)N(H)(CH 2 ) p O(CH 2 ) m N 3 , —O(CH 2 ) q C≡CH, or
R 7 is H,
halo, cyano, —C(═O)N(H)(CH 2 ) p O(CH 2 ) m N 3 , —O(CH 2 ) q C(═O)N(H)(CH 2 ) p O(CH 2 ) m N 3 , —O(CH 2 ) m N 3 , —O(CH 2 ) m C≡CH, C 1 -C 6 alkoxy, optionally substituted C 1 -C 6 linear or branched alkyl, haloalkyl, optionally substituted aryl; optionally substituted arylalkyl, or halogen substituted C 1 -C 6 alkoxy;
R 8 and R 9 are independently H, OH, ═O, halo, or C 1 -C 6 alkyl;
p and q are independently 1-6; and
t and u are independently 0-6,
wherein
m is 1-6.
2. The method of treating tuberculosis of claim 1 , wherein the tuberculosis is a non-replicating tuberculosis.
3. The method of treating tuberculosis of claim 1 , wherein the tuberculosis is a replicating tuberculosis.
4. The method of treating tuberculosis of claim 1 , wherein the compound is selected from the group consisting of:
5. The method of treating tuberculosis of claim 1 , wherein the compound is: