Substituted aldehyde compounds and methods for their use in increasing tissue oxygenation

1. A compound of Formula (I):

a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein:

Q is cycloalkyl or cycloalkenyl, each of which is substituted with one to three R a ;

Y is CR 1a R 1b , wherein

R 1a is H or halo, and

R 1b is H or halo;

X is 0;

T 1 , T 2 , T 3 , and T 4 are independently C or N provided that at least one of T 1 , T 2 , T 3 , and T 4 is C; wherein when T 1 , T 2 , T 3 , or T 4 are N, then R 2 , R 3 , R 4 , or R 5 , respectively, are absent;

R 2 , R 3 , and R 4 are independently hydrogen, halo, R b , OR d , or NR d NR d ;

R 5 is selected from the group consisting of hydrogen, halo, R b , OR d , —O(CH 2 ) z OR d , —O(CH 2 ) z NR d R d , OC(O)R e , SR d , CN, NO 2 , CO 2 R d , CONR d R d , C(O)R d , OC(O)NR d R d , NR d R d , NR d C(O)R e , NR d C(O) 2 R e , NR d C(O)NR d R d , S(O)R e , S(O) 2 R e , NR d S(O) 2 R e , S(O) 2 NR d R d , and N 3 ; wherein z is 0, 1, 2, 3, 4, 5, or 6; or

R 5 is —(CH 2 ) p R 5a , wherein p is 0 or 1 and R 5a is OH;

R 6 and R 7 together form oxo or an aldehyde protecting group, or

R 6 together with R 1b or R 5 forms a cyclic ether, wherein

one of R 1b or R 5a is O, R 6 is a bond, and

R 7 is selected from the group consisting of OH, C 1-8 alkoxy, and haloC 1-8 alkoxy;

each R a is independently selected from the group consisting of halo, R b , OR d , —(CH 2 ) k CO 2 (C 1-8 alkyl)OH, —(CH 2 ) k CO 2 R d , —(CH 2 ) k CONR d R d , —(CH 2 ) k C(O)R d , —(CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , and —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c ; wherein k is 0, 1, 2, 3, 4, 5, or 6; and wherein at least one of R a is selected from the group consisting of OR d , —(CH 2 ) k CO 2 (C 1-8 alkyl)OH, —(CH 2 ) k CO 2 R d , —(CH 2 ) k CONR d R d , —(CH 2 ) k C(O)R d , —(CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c , substituted C 1-8 alkyl, substituted C 2-8 alkenyl, and substituted C 2-8 alkynyl; wherein the substituted C 1-8 alkyl, substituted C 2-8 alkenyl, and substituted C 2-8 alkynyl are each substituted with one to three halo, OR d , or NR d R d ;

each R b is independently selected from the group consisting of C 1-8 alkyl, C 2-8 alkenyl, and C 2-8 alkynyl, each optionally independently substituted with one to three halo, OR d , or NR d R d ;

each R c is independently selected from the group consisting of halo, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, haloC 2-8 alkynyl, (CH 2 ) m OR f , heteroaryl, cycloalkyl, and heterocycloalkyl; wherein m is selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6;

each R d is independently selected from the group consisting of hydrogen, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, haloC 2-8 alkynyl, —(CH 2 ) k heterocycloalkyl, and —(CH 2 ) u O—(CH 2 ) u H; wherein k is 0, 1, 2, 3, 4, 5, or 6 and each u is independently 1, 2, 3, 4, 5, or 6;

each R f is independently selected from the group consisting of hydrogen, C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, and haloC 2-8 alkynyl; and

R e is C 1-8 alkyl, haloC 1-8 alkyl, C 2-8 alkenyl, haloC 2-8 alkenyl, C 2-8 alkynyl, or haloC 2-8 alkynyl;

provided that:

at least one of R 4 and R 5 is other than hydrogen or

T 1 and T 3 are C; T 2 is N and T 4 is C, or T 2 is C and T 4 is N.

2. The compound according to claim 1 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein:

T 1 , T 2 , T 3 , and T 4 are C.

3. The compound according to claim 2 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein:

R 2 , R 3 , R 4 , and R 5 are independently hydrogen, halo, R b , or OR d .

4. The compound according to claim 3 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Y is CH 2 .

5. The compound according to claim 1 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein R 5 is OH; and R 2, R 3 and R 4 are hydrogen.

6. The compound according to claim 5 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Q is cyclopentyl or cyclohexyl.

7. The compound according to claim 6 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein each R a is independently selected from the group consisting of R b , OR d , —(CH 2 ) k CO 2 R d , —(CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 )kheteroaryl optionally substituted with one to three R c , and —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c ; wherein k is 0, 1, 2, 3, 4, 5, or 6; and wherein at least one of R a is selected from the group consisting of OR d , —(CH 2 ) k CO 2 R d , —(CH 2 )karyl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c , substituted C 1-8 alkyl, substituted C 2-8 alkenyl, and substituted C 2-8 alkynyl, wherein the substituted C 1-8 alkyl, substituted C 2-8 alkenyl, and substituted C 2-8 alkynyl are each substituted with one to three halo, OR d , or NR d R d .

8. The compound according to claim 6 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Q is substituted with one R a which is heteroaryl optionally substituted with one to three R c .

9. The compound according to claim 8 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein R a is selected from the group consisting of pyridinyl, pyrazolyl, and imidazolyl, and wherein each R c is independently selected from the group consisting of halo, OR f , C 1-8 alkyl, haloC 1-8 alkyl, cycloalkyl, and heterocycloalkyl.

10. A compound according to claim 8 , a tautomer, a stereoisomer, a mixture of stereoisomers, a pharmaceutically acceptable salt thereof, wherein R a is selected from the group consisting of 2-chloropyridin-3-yl, 2-methoxypyridin-3-yl, 2-cyclobutylpyrazol-3-yl, 2-cyclopentylpyrazol-3-yl, 2-cyclopropylpyrazol-3-yl, 2-ethylpyrazol-3-yl, 2-propan-2-ylpyrazol-3-yl, 2-propylpyrazol-3-yl, 2-(2,2,2-trifluoroethyl)pyrazol-3-yl, 2-(2,2-difluoroethyl)pyrazol-3-yl, 2-(3,3,3-trifluoropropyl)pyrazol-3-yl, 2-(oxetan-3-yl)pyrazol-3-yl, 2-propan-2-ylpyrazol-3-yl, 2-propylpyrazol-3-yl, and 3-propan-2-ylimidazol-4yl.

11. The compound according to claim 5 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Q is cyclopentenyl or cyclohexenyl.

12. The compound according to claim 11 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein each R a is independently selected from the group consisting of R b , OR d , —(CH 2 ) k CO 2 R d , —(CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , and —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c ; wherein k is 0, 1, 2, 3, 4, 5, or 6; and wherein at least one of R a is selected from the group consisting of OR d , —(CH 2 ) k CO 2 R d , —(CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c , substituted C 1-8 alkyl, substituted C 2-8 alkenyl, and substituted C 2-8 alkynyl; wherein the substituted C 1-8 alkyl, substituted C 2-8 alkenyl, and substituted C 2-8 alkynyl are each substituted with one to three halo, OR d , or NR d R d .

13. The compound according to claim 12 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Q is substituted with one R a which is heteroaryl optionally substituted with one to three R c .

14. The compound according to claim 13 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein R a is selected from the group consisting of pyridinyl, pyrazolyl, and imidazolyl, and wherein each R c is independently selected from the group consisting of halo, OR f , C 1-8 alkyl, haloC 1-8 alkyl, cycloalkyl, and heterocycloalkyl.

15. The compound according to claim 14 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein R a is selected from the group consisting of 2-chloropyridin-3-yl, 2-methoxypyridin-3-yl, 2-cyclobutylpyrazol-3-yl, 2-cyclopentylpyrazol-3-yl, 2-cyclopropylpyrazol-3-yl, 2-ethylpyrazol-3-yl, 2-propan-2-ylpyrazol-3-yl, 2-propylpyrazol-3-yl, 2-(2,2,2-trifluoroethyl)pyrazol-3-yl, 2-(2,2-difluoroethyl)pyrazol-3-yl, 2-(3,3,3-trifluoropropyl)pyrazol-3-yl, 2-(oxetan-3-yl)pyrazol-3-yl, 2-propan-2-ylpyrazol-3-yl, 2-propylpyrazol-3-yl, and 3-propan-2-ylimidazol-4 -yl.

16. The compound according to claim 1 , a tautomer, a stereoisomer, a mixture of stereoisomers, a pharmaceutically acceptable salt thereof, wherein at least one of T 1 , T 2 , T 3 , and T 4 is N.

17. The compound according to claim 16 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein:

T 1 and T 3 are C;

T 2 is N and T 4 is C, or T 2 is C and T 4 is N;

R 2 , R 3 , R 4 , and R 5 are independently hydrogen, halo, R b , or OR d .

18. The compound according to claim 17 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein:

T 2 is N and T 4 is C;

R 2 , R 3 , and R 4 are hydrogen; and

R 5 is OR d wherein R d is hydrogen.

19. The compound according to claim 17 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Q is cyclopentyl or cyclohexyl.

20. The compound according to claim 19 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein each R c is independently selected from the group consisting of R b , OR d , —(CH 2 ) k CO 2 R d , —(CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , and —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c ; wherein k is 0, 1, 2, 3, 4, 5, or 6; and wherein at least one of R a is selected from the group consisting of OR d , —(CH 2 ) k CO 2 R d , —(CH 2 ) k aryl optionally substituted with one to three R c , —(CH 2 ) k heteroaryl optionally substituted with one to three R c , —(CH 2 ) k heterocycloalkyl optionally substituted with one to three R c , substituted C 1-8 alkyl, substituted C 2-8 alkenyl, and substituted C 2-8 alkynyl; wherein the substituted C 1-8 alkyl, substituted C 2-8 alkenyl, and substituted C 2-8 alkynyl are each substituted with one to three halo, OR d , or NR d R d .

21. The compound according to claim 20 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein Q is substituted with one R a which is heteroaryl optionally substituted with one to three R c .

22. The compound according to claim 21 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein R a is selected from the group consisting of pyridinyl, pyrazolyl, and imidazolyl, and wherein each R c is independently selected from the group consisting of halo, OR f , C 1-8 alkyl, haloC 1-8 alkyl, cycloalkyl, and heterocycloalkyl.

23. The compound according to claim 21 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof, wherein R a is selected from the group consisting of 2-chloropyridin-3-yl, 2-methoxypyridin-3-yl, 2-cyclobutylpyrazol-3-yl, 2-cyclopentylpyrazol-3-yl, 2-cyclopropylpyrazol-3-yl, 2-ethylpyrazol-3-yl, 2-propan-2-ylpyrazol-3-yl, 2-propylpyrazol-3-yl, 2-(2,2,2-trifluoroethyl)pyrazol-3-yl, 2-(2,2-difluoroethyl)pyrazol-3-yl, 2-(3,3,3-trifluoropropyl)pyrazol-3-yl, 2-(oxetan-3-yl)pyrazol-3-yl, 2-propan-2-ylpyrazol-3-yl, 2-propylpyrazol-3-yl, and 3-propan-2-ylimidazol-4 -yl.

24. A compound selected from the group consisting of

cis-methyl4-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylate;

cis-4((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylic acid;

(1R,3S)-3-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylic acid;

trans-methyl4-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylate;

trans-4-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylic acid;

methyl3-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylate;

trans-methyl4-((2-formyl-3-methoxyphenoxy)methyl)cyclohexanecarboxylate;

2-hydroxy-6-((3,4,5,6-tetrahydro-[1,1’-biphenyl]-2-yl)methoxy)benzaldehyde;

2-hydroxy-6-((2-phenylcyclohexyl)methoxy)benzaldehyde;

2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)cyclohex-1-en-1-yl)methoxy)benzaldehyde;

2-hydroxy-6-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

2-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy--[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[(2-phenylcyclohexyl)methoxy]benzaldehyde;

2-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-6-hydroxybenzaldehyde;

2-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-6-hydroxybenzaldehyde;

2-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]benzaldehyde;

2-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]benzaldehyde;

2-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-6-hydroxybenzaldehyde;

2-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

2-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]-3-methylbenzaldehyde;

2-hydroxy-6-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]-3-methylbenzaldehyde;

2-hydroxy-6-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]-3-methylbenzaldehyde;

6-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

2-hydroxy-3-methyl-64[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]benzaldehyde;

6-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

6-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

6-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

6-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

2-hydroxy-6-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]-3-methylbenzaldehyde;

2-hydroxy-3-methyl-6-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-3-methyl-6-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

6-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

2-hydroxy-3-methyl-6-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-3-methyl-6-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-3-methyl-6-[(2-phenylcyclohexyl)methoxy]benzaldehyde;

2-hydroxy-3-methyl-6-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]-3-methylbenzaldehyde;

6-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

6-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]benzaldehyde;

3-chloro-6-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-2-hydroxy-6-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]benzaldehyde;

3-chloro-6-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-2-hydroxy-6-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[(2-phenylcyclohexyl)methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

3-chloro-6-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-6-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-6-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]benzaldehyde;

3-chloro-6-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-6-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-6-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]benzaldehyde;

2-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]benzaldehyde;

2-fluoro-6[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

2-fluoro-6[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxyThenzaldehyde;

2-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-6-fluorobenzaldehyde;

2-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]benzaldehyde;

2-fluoro-6-[(2-phenylcyclohexyl)methoxy]benzaldehyde;

2-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(2-fluorophenyl)cyclohexyl]methoxy]benzaldehyde;

2-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-6-fluorobenzaldehyde;

2-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]benzaldehyde;

2-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-6-hydroxybenzaldehyde;

2-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-6-hydroxybenzaldehyde;

2-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-hydroxybenzaldehyde;

2-hydroxy-6-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]-3-methylbenzaldehyde;

2-hydroxy-6-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]-3-methylbenzaldehyde;

2-hydroxy-6-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]-3-methylbenzaldehyde;

6-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

2-hydroxy-3-methyl-6-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

6-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

6-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

6-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

6-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

2-hydroxy-6-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]-3-methylbenzaldehyde;

2-hydroxy-3-methyl-6-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-3-methyl-6-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

6-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

2-hydroxy-3-methyl-6-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-3-methyl-6-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-3-methyl-6-[(2-phenylcyclohexen-1-yl)methoxy]benzaldehyde;

2-hydroxy-3-methyl-6-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-hydroxy-6-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]-3-methylbenzaldehyde;

6-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

6-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxy-3-methylbenzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-6-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-2-hydroxy-6-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-6-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-2-hydroxy-6-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[(2-phenylcyclohexen-1-yl)methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-6-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-6-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-6-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-6-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-6-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-6-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxybenzaldehyde;

3-chloro-2-hydroxy-6-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-chloro-2-hydroxy-6-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-fluoro-6-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-fluoro-6-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-fluoro-6-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-fluorobenzaldehyde;

2-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-fluoro-6-[(2-phenylcyclohexen-1-yl)methoxy]benzaldehyde;

2-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-fluorobenzaldehyde;

2-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

2-fluoro-6-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]benzaldehyde;

2-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-fluorobenzaldehyde;

2-fluoro-6-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]benzaldehyde;

3-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[(2-phenylcyclohexyl)methoxy]pyridine-2-carbaldehyde;

3-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[242-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-2-carbaldehyde;

6-methyl-3-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-2-carbaldehyde;

6-methyl-3-[(2-phenylcyclohexyl)methoxy]pyridine-2-carbaldehyde;

3-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-2-carbaldehyde;

3-chloro-5-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-chlorophenyl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-fluorophenyl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[(2-phenylcyclohexyl)methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-methyl-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[(2-phenylcyclohexyl)methoxy]pyridine-4-carbaldehyde;

3-[[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexyl]methoxy]- 5-hydroxypyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-hydroxy-5-[(2-phenylcyclohexyl)methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-methoxy-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-methoxy-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-methoxy-5-[(2-phenylcyclohexyl)methoxy]pyridine-4-carbaldehyde;

3-methoxy-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

5-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

2-hydroxy-5-[(2-phenylcyclohexyl)methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

5-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

5-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-methoxy-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-methoxy-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-methoxy-5-[(2-phenylcyclohexyl)methoxy]pyridine-4-carbaldehyde;

5-[[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[(2-phenylcyclohexyl)methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxybutan-2-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxypropan-2-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxypentan-2-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-chlorophenyl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-54[2-(2-propylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[(2-phenylcyclohexyl)methoxy]pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-methoxypyridin-3-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-ethylpyrazol-3-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-chloropyridin-3-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-fluorophenyl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-methoxyphenyl)cyclohexyl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexyl]methoxy]pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexyl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-2-carbaldehyde;

3-[[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

6-methyl-3-[[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

6-methyl-3-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-2-carbaldehyde;

3-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

3-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]-6-methylpyridine-2-carbaldehyde;

6-methyl-3-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-2-carbaldehyde;

3-chloro-5-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-chloro-5-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-methyl-5-[[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-4-carbaldehyde;

3-[[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-(3-propan-2-yhmidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-5-methylpyridine-4-carbaldehyde;

3-methyl-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(3-propan-2-yhmidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-hydroxy-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-hydroxy-5-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-hydroxypyridine-4-carbaldehyde;

3-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-methoxy-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-methoxy-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-methoxy-5-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-4-carbaldehyde;

3-methoxy-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

3-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-5-methoxypyridine-4-carbaldehyde;

3-methoxy-5-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

5-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

2-hydroxy-5-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-hydroxy-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

5-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-2-hydroxypyridine-4-carbaldehyde;

5-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-methoxy-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-methoxy-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-methoxy-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-methoxy-5-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-4-carbaldehyde;

5-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-methoxypyridine-4-carbaldehyde;

2-methoxy-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-(2-methoxyethoxy)-5-[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-(2-methoxyethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxybutan-2-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxypropan-2-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-hydroxypentan-2-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-[2-(3,3,3-trifluoropropyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-chlorophenyl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-(2-propylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[(2-phenylcyclohexen-1-yl)methoxy]pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5[[2-[2-(2,2,2-trifluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclobutylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-methoxypyridin-3-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-ethylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-(2-propan-2-ylpyrazol-3-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde;

5-[[2-(2-cyclopentylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-chloropyridin-3-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-[2-(2,2-difluoroethyl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-fluorophenyl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-cyclopropylpyrazol-3-yl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

5-[[2-(2-methoxyphenyl)cyclohexen-1-yl]methoxy]-2-(2-morpholin-4-ylethoxy)pyridine-4-carbaldehyde;

2-(2-morpholin-4-ylethoxy)-5-[[2-[2-(oxetan-3-yl)pyrazol-3-yl]cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde; and

2-(2-morpholin-4-ylethoxy)-5-[[2-(3-propan-2-ylimidazol-4-yl)cyclohexen-1-yl]methoxy]pyridine-4-carbaldehyde,

or a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof.

25. A compound according to claim 24 , selected from the group consisting of

cis-methyl4-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylate;

cis-4-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylic acid;

(1R,3S)-3-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylic acid;

trans-methyl4-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylate;

trans-4-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylic acid;

methyl3-((2-formyl-3-hydroxyphenoxy)methyl)cyclohexanecarboxylate;

trans-methyl4-((2-formyl-3-methoxyphenoxy)methyl)cyclohexanecarboxylate;

2-hydroxy-6-((3,4,5,6-tetrahydro-[1,1′-biphenyl]-2-yl)methoxy)benzaldehyde;

2-hydroxy-6-((2-phenylcyclohexyl)methoxy)benzaldehyde; and

2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5-yl)cyclohex-1-en-1-yl)methoxy)benzaldehyde,

or a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof.

26. A pharmaceutical composition comprising a compound of claim 1 , a tautomer, a stereoisomer, a mixture of stereoisomers, or a pharmaceutically acceptable salt thereof.