Cycloalkyl nitrile pyrazolo pyridones as Janus kinase inhibitors

1. A compound of formula I or a pharmaceutically acceptable salt, or a stereoisimer thereof:

A is selected from aryl and heteroaryl;

n is 0, 1, 2, 3, or 4;

m is 0, 1, 2, 3, or 4;

p is 0, 1, 2, 3, or 4;

R 1 is selected from:

halogen,

Oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 2-10 alkenyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

(C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

C 0-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl,

(C 1-10 )heteroalkylamino(carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkylamino(carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkylaminoamino(carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkylamino(carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkylsulfonylC 0-10 alkyl,

C 1-10 heteroalkylsulfonylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfonylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfonylC 0-10 alkyl,

arylC 0-10 alkylsulfonylC 0-10 alkyl,

C 1-10 alkylsulfamoylC 0-10 alkyl,

C 1-10 heteroalkylsulfamoylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfamoylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfamoylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfamoylC 0-10 alkyl,

arylC 0-10 alkylsulfamoylC 0-10 alkyl,

C 1-10 alkylsulfonimidoylC 0-10 alkyl,

C 1-10 heteroalkylsulfonimidoylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkysulfonimidoylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

arylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

C 1-10 alkylthioC 0-10 alkyl,

(C 0-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

—SO 2 NH 2 ,

—SO 2 NH(C 1-10 alkyl),

—SO 2 N(C 1-10 alkyl) 2 ,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

C 1-10 alkylsulfinylC 0-10 alkyl,

C 1-10 heteroalkylsulfinylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfinylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfinylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfinylC 0-10 alkyl,

arylC 0-10 alkylsulfinylC 0-10 alkyl,

C 0-10 alkylsulfinylaminoC 0-10 alkyl,

C 1-4 acylamino C 0-10 alkyl,

hydroxy,

—(C 1-10 alkyl)OH,

—C 1-10 alkylalkoxy,

cyano,

(C 1-6 alkyl)cyano, and

C 1-6 haloalkyl; and

wherein two R 1 may optionally join together with the ring atom to which they are attached to form a 3 to 6 membered ring;

R 2 is selected from:

halogen,

Oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkylaminoC 0-10 alkyl,

(C 1-10 )heteroalkylaminoC 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

aryl C 0-10 alkylaminoC 0-10 alkyl,

heteroaryl C 0-10 alkylaminoC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

C 1-10 alkylsulfonyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfonyl,

(C 0-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

C 1-10 alkylsulfinyl,

hydroxy,

—(C 1-10 alkyl)OH,

—C 1-10 alkylalkoxy,

cyano,

(C 1-6 alkyl)cyano, and

C 1-6 haloalkyl, and

wherein two R 2 may optionally join together with the ring atom to

which each is attached to form a 3 to 6 membered saturated ring; and

wherein R 1 and R 2 are each optionally substituted with 1, 2, 3, or 4 R 3 substituents;

R 3 is independently selected from:

halogen,

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, and

C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 2-10 alkenyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

((C 0-10 )alkyl) 1-2 aminocarbonyloxy,

aryl (C 0-10 )alkylaminocarbonyloxy,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

Oxo (═O),

—SO 2 NH 2 ,

—SO 2 NH(C 1-10 alkyl),

—SO 2 N(C 1-10 alkyl) 2 ,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

C 1-10 alkylsulfinyl,

amino,

(C 0-10 alkyl) 1-2 amino,

-(oxy) 0-1 (carbonyl) 0-1 N(C 0-10 alkyl) 1-2

hydroxy,

(C 1-10 alkyl)OH,

C 1-10 alkoxy,

(C 1-10 alkyl)cyano,

cyano, and

C 1-6 haloalkyl; and

R 3 is optionally substituted with 1, 2, or 3 R 4 substituents selected from hydrogen, hydroxy, (C 1-6 )alkyl, (C 1-6 )alkoxy, (C 1-10 alkyl)OH, halogen, CO 2 H, —(C 0-6 )alkylCN, —O(C═O)C 1 -C 6 alkyl, NO 2 , trifluoromethoxy, trifluoroethoxy, trifluoromethyl, trifluoroethyl, —N—C(O)O(C 0-6 )alkyl, C 1-10 alkylsulfonyl, oxo (O═), aminosulfonyl, —SO 2 NH 2 , —SO 2 NH(C 1-10 alkyl), —SO 2 N(C 1-10 alkyl) 2 , —SO 2 C 1-6 alkyl, —SO 2 CF 3 , —SO 2 CF 2 H, —C 1-10 alkylsulfinyl, —O (0-1) (C 1-10 )haloalkyl, amino(C 1-6 alkyl) 0-2 and NH 2 .

2. A compound of claim 1 , where R 1 is selected from: halogen, Oxo (═O), C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, (C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, (C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, (C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, C 0-10 alkylsulfonylC 0-10 alkyl, (C 3-12 )cycloheteroalkylC 0-10 alkylsulfonylalkyl)C 0-10 alkyl, C 1-10 alkylsulfamoylC 0-10 alkyl, (C 3-12 )cycloalkylC 0-10 alkylsulfamoylC 0-10 alkyl, (C 3-12 )cycloheteroalkylC 0-10 alkylsulfamoylC 0-10 alkyl, arylC 0-10 alkylsulfamoylC 0-10 alkyl, C 1-10 alkylsulfonimidoylC 0-10 alkyl, C 1-10 alkylthioC 0-10 alkyl, (C 0-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl), —(C 0-10 alkyl)CO 2 H, —SO 2 NH 2 , —SO 2 NH(C 1-10 alkyl), —SO 2 N(C 1-10 alkyl) 2 , hydroxy, —(C 1-10 alkyl)OH, —C 1-10 alkylalkoxy, cyano, and C 1-6 haloalkyl; wherein two R 1 may optionally join together with the ring atoms to which they are attached to form a 3 to 6 membered ring; and wherein R 1 is optionally substituted with 1, 2, 3, or 4 R 3 substituents.

3. A compound of claim 2 , wherein A is selected from: phenyl, isoindolinyl, 2,3-dihydro-1H-isoindolyl, quinolinyl, pyridinyl,

2,3-dihydro-1H-indenyl, benzothiazolyl, 1,3-benzothiazolyl, and 1,2,3,4-tetrahydroisoquinolinyl.

4. A compound of claim 3 , wherein R 1 is selected from: fluoro, methylsulfonyl, chloro, trifluoromethyl, trifluoromethoxy, dimethylsulfamoyl, sulfamoyl, hydroxyethyl, trifluoroethyl, pyrazolylcarbamoylmethyl, pyrazolylcarbonylaminomethyl, tert-butyloxycarbonylaminomethyl, aminomethyl, isopropylsulfamoyl, benzylsulfamoyl, (cyclopropylmethyl)sulfamoyl, ethylsulfomoyl, cyclohexylsulfamoyl, piperidinylsulfonyl, morpholinylsulfonyl, triazolylmethyl, pyrrolidinylcarbonyl, oxazolylcarbonylaminomethyl, pyrimidinylcarbonylaminomethyl, hydroxyethyl, 1-hydroxyethyl, morpholinylmethyl, 1-hydroxymethylethyl, hydroxy(methylpropyl), 1-hydroxy(methylpropyl), hydroxypropyl, ethylhydroxy, (tert-butyl)sulfinylaminomethyl, dioxolanyl, methylaminomethyl, methylcarbonylaminomethyl, (dimethylamino)methyl, pyrazolylmethyl, imidazolylmethyl, oxo, hydroxy, hydroxymethyl, methyl, tert-butyl, (tert-butyl)sulfinylaminomethyl, (ethyl)aminomethyl, pyrrolidinylsulfonylmethyl, trifluoroethyl, (2,2,2,-trifluoroethyl), carboxy, cyclopropylmethyl, dimethylaminomethyl, cyclopentylmethyl, methylaminoethyl,

1-(methylamino)ethyl, ethylaminomethyl, dimethylaminocarbonyl, dimethylcarbamoyl, morpholinylcarbonyl, cyclopropyl, aminoethyl, 1-aminoethyl, pyrrolidinyl, methylethyl, isobutyl, cyclopropylmethyl, methylsulfanylmethyl, 3-hydroxy(dimethylpropyl), triazolylmethyl, 3-hydroxy-2,2,-dimethylpropyl, and methoxyethyl; wherein R 1 is optionally substituted with 1, 2, 3, or 4 R 3 substituents.

5. A compound of formula II or pharmaceutically acceptable salt, or stereoisomer thereof:

A is selected from aryl and heteroaryl;

n is 0, 1, or 2;

m is 0, 1, 2, or 3;

p is 0, 1, 2, 3, or 4;

R 1a is selected from:

halogen,

Oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

(C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

C 0-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl,

(C 0-10 alkyl) 1-2 amino,

C 1-10 alkylthioC 0-10 alkyl,

C 0-10 alkylsulfonylC 0-10 alkyl,

—SO 2 NH 2 ,

—SO 2 NH(C 1-10 alkyl),

—SO 2 N(C 1-10 alkyl) 2 ,

hydroxy,

—(C 1-10 alkyl)OH,

—C 1-10 alkylalkoxy, and

C 1-6 haloalkyl, and

wherein two R 1a may optionally join together with the ring atoms to which they are attached to form a 3 to 6 membered saturated ring;

R 2a is selected from

halogen,

Oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkylaminoC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

(C 0-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

hydroxy,

—(C 1-10 alkyl)OH,

—C 1-10 alkylalkoxy, and

C 1-6 haloalkyl, wherein two R 2a may optionally join together with the ring atom to which each is attached to form a 3 to 6 membered saturated ring;

wherein R 1a and R 2a are independently optionally substituted with 1, 2, 3, or 4 R 3a substituents;

R 3a is independently selected from:

halogen,

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, and

C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

Oxo (═O),

hydroxy,

(C 1-10 alkyl)OH,

C 1-10 alkoxy, and

C 1-6 haloalkyl;

R 3a is optionally substituted with 1, 2, or 3 R 4a substituents selected from hydrogen, hydroxy, (C 1-6 )alkyl, (C 1-6 )alkoxy, (C 1-10 alkyl)OH, halogen, CO 2 H, —(C 0-6 )alkylCN, —O(C═O)C 1 -C 6 alkyl, NO 2 , trifluoromethoxy, trifluoroethoxy, trifluoromethyl, trifluoroethyl, —N—C(O)O(C 0-6 )alkyl, C 1-10 alkylsulfonyl, oxo (O═), aminosulfonyl,

—SO 2 NH 2 , —SO 2 NH(C 1-10 alkyl), —SO 2 N(C 1-10 alkyl) 2 , —SO 2 C 1-6 alkyl, —SO 2 CF 3 , —SO 2 CF 2 H, —C 1-10 alkylsulfinyl, —O (0-1) (C 1-10 )haloalkyl, amino(C 1-6 alkyl) 0-2 and NH 2 ;

R 1b is selected from:

hydrogen,

halogen,

Oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 2-10 alkenyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

(C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

C 0-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl,

(C 1-10 )heteroalkylamino(carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkylamino(carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkylaminoamino(carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkylamino(carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkylsulfonylC 0-10 alkyl,

C 1-10 heteroalkylsulfonylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfonylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfonylC 0-10 alkyl,

arylC 0-10 alkylsulfonylC 0-10 alkyl,

C 1-10 alkylsulfamoylC 0-10 alkyl,

C 1-10 heteroalkylsulfamoylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfamoylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfamoylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfamoylC 0-10 alkyl,

arylC 0-10 alkylsulfamoylC 0-10 alkyl,

C 1-10 alkylsulfonimidoylC 0-10 alkyl,

C 1-10 heteroalkylsulfonimidoylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkysulfonimidoylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

arylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

C 1-10 alkylthioC 0-10 alkyl,

(C 0-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

—SO 2 NH 2 ,

—SO 2 NH(C 1-10 alkyl),

—SO 2 N(C 1-10 alkyl) 2 ,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

C 1-10 alkylsulfinylC 0-10 alkyl,

C 1-10 heteroalkylsulfinylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfinylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfinylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfinylC 0-10 alkyl,

arylC 0-10 alkylsulfinylC 0-10 alkyl,

C 0-10 alkylsulfinylaminoC 0-10 alkyl,

C 1-4 acylamino C 0-10 alkyl,

hydroxy,

—(C 1-10 alkyl)OH,

—C 1-10 alkylalkoxy,

cyano,

(C 1-6 alkyl)cyano, and

C 1-6 haloalkyl;

R 2b is selected from:

hydrogen,

halogen,

Oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkylaminoC 0-10 alkyl,

(C 1-10 )heteroalkylaminoC 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

aryl C 0-10 alkylaminoC 0-10 alkyl,

heteroaryl C 0-10 alkylaminoC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

C 1-10 alkylsulfonyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfonyl,

(C 0-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

C 1-10 alkylsulfinyl,

hydroxy,

—(C 1-10 alkyl)OH,

—C 1-10 alkylalkoxy,

cyano,

(C 1-6 alkyl)cyano, and

C 1-6 haloalkyl; wherein R 1b and R 2b are each optionally substituted with 1, 2, or 3 R 3b substituents;

R 3b is independently selected from: is independently selected from: halogen, C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, (C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, —CO 2 (C 0-10 alkyl), Oxo (═O), C 1-10 alkylsulfinyl, amino, (C 0-10 alkyl) 1-2 amino, hydroxy, (C 1-10 alkyl)OH, C 1-10 alkoxy, (C 1-10 alkyl)cyano, cyano, and C 1-6 haloalkyl, halogen, C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, Oxo (═O), amino, hydroxy, (C 1-10 alkyl)OH, C 1-10 alkoxy, and C 1-6 haloalkyl; wherein R 3b is optionally substituted with 1, 2, or 3 R 4b substituents; and

R 4b is independently selected from hydrogen, hydroxy, (C 1-6 )alkyl, (C 1-6 )alkoxy, (C 1-10 alkyl)OH, halogen, —O(C═O)C 1 -C 6 alkyl, trifluoromethoxy, trifluoroethoxy, trifluoromethyl, trifluoroethyl, oxo (O═), —O (0-1) (C 1-10 )haloalkyl, amino(C 1-6 alkyl) 0-2 and NH 2 .

6. A compound according to claim 5 , wherein: R 1b is selected from: halogen, Oxo (═O), C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, (C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, (C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, (C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, C 0-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl, heteroaryl C 0-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl, C 0-10 alkylsulfonylC 0-10 alkyl, (C 3-12 )cycloheteroalkylC 0-10 alkylsulfonylC 0-10 alkyl, C 1-10 alkylsulfamoylC 0-10 alkyl, (C 3-12 )cycloalkylC 0-10 alkylsulfamoylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfamoylC 0-10 alkyl, arylC 0-10 alkylsulfamoylC 0-10 alkyl, C 1-10 alkylsulfonimidoylC 0-10 alkyl, C 1-10 alkylthioC 0-10 alkyl, (C 0-10 alkyl) 1-2 amino, —CO 2 (C 0-10 alkyl), —(C 0-10 alkyl)CO 2 H, —SO 2 NH 2 , —SO 2 NH(C 1-10 alkyl), —SO 2 N(C 1-10 alkyl) 2 , hydroxy, —(C 1-10 alkyl)OH, —C 1-10 alkylalkoxy, cyano, and C 1-6 haloalkyl;

R 2b is selected from: hydrogen, halogen, C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 3-12 cycloalkyl, (C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 0-10 alkylaminoC 0-10 alkyl, C 3-12 cycloalkyl C 0-10 alkylaminoC 0-10 alkyl, (C 0-10 alkyl) 1-2 amino, and hydroxy; and wherein R 1b and R 2b are each independently optionally substituted with 1, 2, 3, or 4 R 3b substituents.

7. A compound of claim 1 or a pharmaceutically acceptable salt, or a stereoisomer thereof selected from:

2-{3-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(2-fluoropyridin-4-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-5-{[1-cyclopropylethyl]amino}cyclohexanecarbonitrile;

5-hydroxy-2-(4-oxo-3-{[4-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

5-azetidin-1-yl-2-(4-oxo-3-{[4-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

5-{[1-cyclopropylethyl]amino}-2-(4-oxo-3-{[4-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

5-{[1-cyclopropylethyl]amino}-2-(4-oxo-3-{[4-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

5-azetidin-1-yl-2-{3-[(4-chloro-3-fluorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(4-chloro-3-fluorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-5-(dimethylamino)cyclohexanecarbonitrile;

2-{3-[(4-chloro-3-fluorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-5-{[1-cyclopropylethyl]amino}cyclohexanecarbonitrile;

5-azetidin-1-yl-2-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-5-(dimethylamino)cyclohexanecarbonitrile;

5-azetidin-1-yl-2-(4-oxo-3-{[4-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

5-{[1-cyclopropylethyl]amino}-2-(4-oxo-3-{[4-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

5-(dimethylamino)-2-(4-oxo-3-{[4-(trifluoromethoxy)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-5-(3-hydroxy-3-methylazetidin-1-yl)cyclohexanecarbonitrile;

2-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-5-(3-hydroxyazetidin-1-yl)cyclohexanecarbonitrile;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzenesulfonamide;

(2-{3-[(2-fluoropyridin-4-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclopentanecarbonitrile;

(2-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

2-[4-oxo-3-({4-[2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(4-oxo-3-{[1-oxo-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

4-({1-[2-cyanocyclopentyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

2-(4-oxo-3-{[1-oxo-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

2-(4-oxo-3-{[4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

4-({1-[2-cyanocyclopentyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzenesulfonamide;

2-[3-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)phenyl]-N-(1-methyl-1H-pyrazol-3-yl)acetamide;

N-[3-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzyl]-1,3-oxazole-5-carboxamide;

N-[3-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzyl]pyrimidine-2-carboxamide;

2-[3-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)phenyl]-N-(1-methyl-1H-pyrazol-3-yl)acetamide;

tert-butyl [3-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzyl]carbamate;

2-(3-{[3-(aminomethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-(1-methylethyl)benzenesulfonamide;

N-benzyl-4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzenesulfonamide;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-(cyclopropylmethyl)benzenesulfonamide;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-(2-methoxyethyl)benzenesulfonamide;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-cyclohexylbenzenesulfonamide;

2-(3-{[4-(morpholin-4-yl sulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[3-methyl-4-(pyrrolidin-1-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(4-oxo-3-{[3-(2H-1,2,3-triazol-2-ylmethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

N-[4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzyl]-1,3-oxazole-5-carboxamide;

N-[4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzyl]pyrimidine-2-carboxamide;

2-(3-{[3-(1-hydroxyethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

tert-butyl [4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzyl]carbamate;

2-(3-{[4-(aminomethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-(aminomethyl)-4-fluorophenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-(morpholin-4-ylmethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

tert-butyl [5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-2-fluorobenzyl]carbamate;

tert-butyl [3-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-5-fluorobenzyl]carbamate;

2-{3-[(3-{[4-(1-hydroxy-1-methylethyl)-1H-1,2,3-triazol-1-yl]methyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-{[3-(1-hydroxy-2-methoxy-1-methylethyl)-4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-(1,3-dihydroxy-1-methylpropyl)-4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-(1,2-dihydroxy-1-methylethyl)-4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[3-(2,3-dihydro-1H-isoindol-5-ylamino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[3-({3-[(4-methyl-1H-1,2,3-triazol-1-yl)methyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[3-({3-[1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

N-{1-[3-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)phenyl]-2,2,2-trifluoroethyl}-2-methylpropane-2-sulfinamide;

2-(4-oxo-3-{[3-(2,2,4-trimethyl-1,3-dioxolan-4-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{4-oxo-3-[(3-{[(2,2,2-trifluoroethyl)amino]methyl}phenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-{[3-(aminomethyl)-4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

6-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)spiro[2.5]octane-5-carbonitrile;

N-[5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-2-(dimethyl sulfamoyl)benzyl]acetamide;

2-[3-({3-[(dimethylamino)methyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[3-(1,2-dihydroxy-1-methylethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

4-{[1-(5-cyanospiro[2.5]oct-6-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl]amino}-N,N-dimethylbenzenesulfonamide;

2-(aminomethyl)-4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

2-(4-oxo-3-{[3-(1H-pyrazol-1-ylmethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(4-oxo-3-{[4-(pyrrolidin-1-ylcarbonyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(4-oxo-3-{[4-(1H-1,2,3-triazol-1-ylmethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-(1H-imidazol-1-ylmethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

6-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)spiro[2.5]octane-5-carbonitrile;

2-(3-{[4-hydroxy-4-(hydroxymethyl)-1,1-dioxido-3,4-dihydro-2H-thiochromen-6-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(2-methyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(4-oxo-3-{[3-(1H-1,2,4-triazol-1-ylmethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(4-oxo-3-{[3-(1H-1,2,4-triazol-4-ylmethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(4-{[4-(1-hydroxy-1-methylethyl)-1H-1,2,3-triazol-1-yl]methyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

N-{1-[4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)phenyl]-2,2,2-trifluoroethyl}-2-methylpropane-2-sulfinamide;

2-[3-({4-[1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclopentanecarbonitrile;

2-{4-oxo-3-[(4-{[(2,2,2-trifluoroethyl)amino]methyl}phenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-[4-oxo-3-({4-[(pyrrolidin-1-yl sulfonyl)methyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(2-ethyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclopentanecarbonitrile;

2-(3-{[1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

2-(4-oxo-3-{[2-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-2,3-dihydro-1H-indene-2-carboxylic acid;

2-{3-[(2-methyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclopentanecarbonitrile;

2-(3-{[2-(cyclopropylmethyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(2-methyl-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-[3-({4-[1-(dimethylamino)-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[2-(cyclopentylmethyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{4-oxo-3-[(4-{1-[(2,2,2-trifluoroethyl)amino]ethyl}phenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N,2-trimethylbenzamide;

2-(3-{[3-methyl-4-(morpholin-4-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-2-cyclopropyl-N,N-dimethylbenzamide;

2-[3-({4-[1-amino-2,2-difluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[4-(2,2-difluoro-1-hydroxyethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[4-oxo-3-({4-[pyrrolidin-2-yl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[2-(1-methylethyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[2-(2-methylpropyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(2-ethyl-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-{[2-(cyclopropylmethyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[3-({3-[(methylsulfanyl)methyl]-5-(1H-1,2,3-triazol-1-ylmethyl)phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[2-(1-methylethyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[2-(2-hydroxyethyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[2-(3-hydroxy-1,1-dimethylpropyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[4-oxo-3-({4-[1-(1H-1,2,3-triazol-1-yl)ethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[3-({4-[1-methyl-1-(1H-1,2,3-triazol-1-yl)ethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[2-(3-hydroxy-2,2-dimethylpropyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[3-({4-[1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclopentanecarbonitrile;

2-(3-{[2-(2-methoxyethyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-(aminomethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[3-({4-[(1-methylethyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclopentanecarbonitrile;

2-(3-{[4-(tert-butylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

N-tert-butyl-4-({1-[2-cyanocyclopentyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzenesulfonamide;

2-(4-oxo-3-((4-(propan-2-methylsulfonimidoyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

2-(3-{[4-(methylsulfonimidoyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

4-({1-[2-cyanocyclopentyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-ylamino)benzonitrile;

2-[3-({4-[1-(ethylamino)-2,2,2-trifluoroethyl]phenylamino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclopentanecarbonitrile;

2-(4-oxo-3-((4-(2,2,2-trifluoro-1-(isopropylamino)ethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

ethyl 3-(4-((1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)phenyl)-4,4,4-trifluoro-3-hydroxy-2,2-dimethylbutanoate;

isopropyl 3-(4-((1-2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)phenyl)-4,4,4-trifluoro-3-hydroxy-2,2-dimethylbutanoate;

2-(3-((1-hydroxy-2,2-dimethyl-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((1′-hydroxy-1′-(trifluoromethyl)-1′,3′-dihydrospiro[cyclopropane-1,2′-inden]-5′-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile

2-(4-oxo-3-((4-(1,1,1-trifluoro-2-methoxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((2,3-dimethyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((3-methyl-1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((4-(4,4-difluoropiperidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((2-(2,5-dimethylmorpholino)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

tert-butyl 4-(5-((1-2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-1-oxoisoindolin-2-yl)cyclohexanecarboxylate;

2-[3-({4-[1-amino-2,2,2-trifluoroethyl]phenylamino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclopentanecarbonitrile;

2-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

N-tert-butyl-4-({1-2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzenesulfonamide;

2-[3-({4-[(1-methylethyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

N-tert-butyl-4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-methylbenzenesulfonamide;

2-(3-{[4-(tert-butylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-methylbenzenesulfonamide;

2-[3-({4-[1-(2-methoxyethyl)-1H-pyrazol-4-yl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[3-chloro-4-(1-methyl-1H-pyrazol-4-yl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[3-({4-[1-methyl-1-(1H-1,2,3-triazol-1-yl)ethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[3-({2-[1,2-dimethylpropyl]-2,3-dihydro-1H-isoindol-5-yl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

tert-butyl 3-[5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]propanoate;

tert-butyl [5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]acetate;

tert-butyl 2-[5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-2-methylpropanoate;

2-(3-{[2-(1-methylethyl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(2-cyclopentyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

tert-butyl 3-[5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]-3-methylbutanoate;

2-[4-oxo-3-(1,2,3,4-tetrahydroisoquinolin-6-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[4-oxo-3-(1,2,3,4-tetrahydroisoquinolin-7-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[4-oxo-3-({2-[(5-piperidin-1-ylpyrazin-2-yl)carbonyl]-2,3-dihydro-1H-isoindol-5-yl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-((2-(3-methoxy-2,2-dimethylpropyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[2-(2-methoxy-1,1-dimethylethyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[2-(3-methoxy-1,1-dimethylpropyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[2-(cyclopentylmethyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

tert-butyl 3-[5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-1,3-dihydro-2H-isoindol-2-yl]propanoate;

tert-butyl [5-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-1,3-dihydro-2H-isoindol-2-yl]acetate;

tert-butyl 3-(4-((1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)phenyl)-8-azabicyclo[3.2.1]octane-8-carboxylate;

2-(3-{[4-(tert-butylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cycloheptanecarbonitrile;

2-{3-[(2,2-dimethyl-1,1-dioxido-3-oxo-2,3-dihydro-1-benzothiophen-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-{[3-hydroxy-2,2-dimethyl-1,1-dioxido-2,3-dihydro-1-benzothiophen-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-hydroxy-1,1-dioxido-3H-spiro[1-benzothiophene-2,1′-cyclohexan]-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cycloheptanecarbonitrile;

2-(3-{[1-methyl-2,3-dihydro-1H-isoindol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[4-(1,3-oxazol-2-yl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(4-oxo-3-{[4-(1,3-thiazol-2-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[4-(1,2,4-oxadiazol-3-yl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(4-isoxazol-3-ylphenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(4-isoxazol-5-ylphenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-{[4-(1,2,4-oxadiazol-5-yl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-{[4-(1,3-oxazol-5-yl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[4-(3-hydroxyoxetan-3-yl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(2-methyl-1,3-benzothiazol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[4-(3-methyloxetan-3-yl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[3-({4-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

ethyl 1-[4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-2-methylphenyl]-1H-pyrazole-4-carboxylate;

isopropyl 6-((1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)quinoline-2-carboxylate;

2-(4-oxo-3-{[4-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[3-({4-[1-(2-cyanoethyl)-1H-pyrazol-4-yl]-3-methylphenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[4-oxo-3-({4-[1-trifluoromethyl)cyclopropyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-{3-[(2-tert-butyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-[4-oxo-3-({4-[1-(2H-1,2,3-triazol-2-yl)ethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[3-({4-[2-methyl-1-(1H-1,2,3-triazol-1-yl)propyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-{4-oxo-3-[(4-piperidin-4-ylphenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-{3-[(2-acetyl-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-{[1-(difluoromethyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[3-({4-[1-methyl-1-(2H-1,2,3-triazol-2-yl)ethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[3-({4-[2-methyl-1-(2H-1,2,3-triazol-2-yl)propyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[3-({3-methyl-4-[1-methyl-1-(2H-1,2,3-triazol-2-yl)ethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-{3-[(2-cyclohexyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-[3-({3-methyl-4-[2-methyl-1-(2H-1,2,3-triazol-2-yl)propyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-[3-({3-methyl-4-[2-methyl-1-(1H-1,2,3-triazol-1-yl)propyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

tert-butyl 4-(4-((1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)phenyl)-4-hydroxycyclohexanecarboxylate;

2-[4-oxo-3-({4-[1-(1H-1,2,3-triazol-1-yl)ethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

tert-butyl 4-(5-((1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)cyclohexanecarboxylate;

2-(3-{[1,1-dioxido-2-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-methyl-4-(pyrrolidin-1-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cycloheptanecarbonitrile;

2-(3-{[2-(3-methoxy-2,2-dimethylpropyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cycloheptanecarbonitrile;

N-tert-butyl-4-({1-[2-cyanocycloheptyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-methylbenzenesulfonamide;

2-{3-[(2-cyclopentyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cycloheptanecarbonitrile;

2-(4-oxo-3-{[2-(piperidin-1-ylcarbonyl)-2,3-dihydro-1H-isoindol-5-yl]amino-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cycloheptanecarbonitrile;

2-(3-{[1,1-dioxido-2-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cycloheptanecarbonitrile;

2-[3-({4-[1-(4-tert-butyl-1H-1,2,3-triazol-1-yl)-2-methylpropyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

tert-butyl 1-{1-[4-({1-[2-cyanocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)phenyl]-2-methylpropyl 1-1H-1,2,3-triazole-4-carboxylate;

2-(4-oxo-3-{[1-oxo-2-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(4-oxo-3-{[1-oxo-2-(tetrahydro-2H-thiopyran-4-yl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-[4-oxo-3-({4-[2-(trifluoromethyl)pyrrolidin-2-yl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile;

2-(3-{[2-(4-methyltetrahydro-2H-pyran-4-yl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[2-(4-methyltetrahydro-2H-pyran-4-yl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-{[3-hydroxy-1,1-dioxido-2′,3′,5′,6′-tetrahydro-3H-spiro[1-benzothiophene-2,4′-pyran]-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((3-methyl-4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cycloheptanecarbonitrile;

4-((1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)benzoic acid;

4-(5-((1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-1,1-dioxidobenzo[d]isothiazol-2(3H)-yl)cyclohexanecarboxylic acid;

4-(4-(1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-ylamino)phenyl)-4-hydroxycyclohexanecarboxylic acid;

tert-butyl 5-((1-(2-cyanocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-1-methylisoindoline-2-carboxylate;

2-(3-((2-isopropyl-1-methylisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((4-(8-azabicyclo[3.2.1]octan-3-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((2,2-dimethyl-1,1-dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-(3-((1,1-dioxido-3H-spiro[benzo[b]thiophene-2, 1′-cyclohexan]-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile;

2-{3-[(1,1-dioxido-2′,3′,5′,6′-tetrahydro-3H-spiro[1-benzothiophene-2,4′-pyran]-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexanecarbonitrile;

2-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4,4-difluorocyclopentanecarbonitrile;

4,4-difluoro-2-(3-{[3-methyl-4-(pyrrolidin-1-ylcarbonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentanecarbonitrile;

2-[4-oxo-3-({4-2-(trifluoromethyl)piperidin-2-yl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cycloheptanecarbonitrile;

2-[4-oxo-3-({4-2-(trifluoromethyl)piperidin-2-yl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclopentanecarbonitrile;

2-(3-{[2-(4,4-difluoro-1-methylcyclohexyl)-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexanecarbonitrile; and

2-[4-oxo-3-({4-[2-(trifluoromethyl)piperidin-2-yl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexanecarbonitrile.

8. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

9. A method for the treatment of a JAK-mediated disease comprising administering to a patient in need thereof a therapeutically effective amount of a compound of claim 1 or a pharmaceutically acceptable thereof.

10. A method of treating a condition in a mammal that can be ameliorated by the inhibition of Janus kinases JAK1 and JAK 2 which condition is selected from, arthritis, asthma and obstructive airways diseases, autoimmune diseases or disorders, and cancer comprising administering to the mammal in need of such treatment, a therapeutically effective amount of a compound according to claim for a pharmaceutically acceptable salt or a stereoisomer thereof.

11. A method according to claim 10 , wherein said condition is arthritis.

12. A method according to claim 11 , wherein said condition is selected from rheumatoid arthritis, juvenile arthritis, and psoriatic arthritis.

13. A method according to claim 10 , wherein said condition is asthma or obstructive airways diseases.

14. A method according to claim 13 , wherein said condition is selected from: chronic asthma, late asthma, airway hyper-responsiveness, bronchitis, bronchial asthma, allergic asthma, intrinsic asthma, extrinsic asthma, dust asthma, recurrent airway obstruction, and chronic obstruction pulmonary disease (COPD), and emphysema.

15. A method according to claim 10 , wherein said condition is autoimmune diseases or disorders.

16. A method of treating asthma characterized by JAK activation in a mammal in need thereof, comprising administering a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.

17. A method of treating arthritis characterized by JAK activation in a mammal in need thereof, comprising administering a therapeutically effective amount of a compound according to claim 1 or a pharmaceutically acceptable salt thereof.