IP Library › Granted Patent US 9,957,264

Granted Patent B2

US 9,957,264 · App. 14/778,046 · Granted May 1, 2018

Geminally substituted cyanoethylpyrazolo pyridones as Janus kinase inhibitors

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Quick Facts

Patent No.: US 9,957,264
App. No.: 14/778,046
Granted: May 1, 2018
Kind: B2

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Abstract

The instant invention provides compounds of Formula (I) which are JAK inhibitors, and as such are useful for the treatment of JAK-mediated diseases such as rheumatoid arthritis, asthma, COPD and cancer.

Claims (829)

1. A compound of Formula I or a pharmaceutically acceptable salt, or a stereoisimer thereof:

A is selected from phenyl, methyl, ethyl, cyclopropylmethyl, cyclopropyl, cyclobutyl, isoindolinyl, benzo[d]thiazolyl,

2,3-dihydro-1H-indenyl, quinolinyl, pyridinyl, and indolinyl;

R 2 and R 3 are each independently selected from hydrogen, C 1-4 alkyl and hydroxy, wherein R 2 and R 3 may optionally, join together with the carbon they are attached to form a 3 to 6 membered ring;

X 1 is C;

X 2 , X 3 , and X 4 are each independently selected from O, N, S, and C and provided that the formed ring system contains 0, 1, 2, or 3 atoms selected from O, N and S;

n is 0, 1, 2, 3 or 4;

m is 0, 1, 2, 3 or 4;

p is 0, 1, 2, 3, or 4;

R 4 is selected from:

halogen,

oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 2-10 alkenyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

C 1-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl,

(C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

(C 1-10 )heteroalkylamino(carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

aryl C 0-10 alkylaminoC 0-10 alkyl,

heteroaryl C 0-10 alkylaminoC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

C 1-10 alkylsulfonyl,

C 1-10 heteroalkylsulfonyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfonyl,

heteroarylC 0-10 alkylsulfonyl,

arylC 0-10 alkylsulfonyl,

—SO 2 NH 2 ,

—SO 2 NH(C 1-6 alkyl),

—SO 2 N(C 1-6 alkyl) 2 ,

C 0-10 alkylsulfamoyl,

C 1-10 heteroalkylsulfamoyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfamoyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfamoyl,

heteroarylC 0-10 alkylsulfamoyl,

arylC 0-10 alkylsulfamoyl,

C 0-10 alkylsulfonimidoylC 0-10 alkyl,

C 1-10 heteroalkylsulfonimidoylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

arylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

(C 1-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

—SO 2 CH 2 CF 3 ,

C 1-10 alkylsulfinyl,

C 1-4 acylaminoC 0-10 alkyl,

hydroxy,

—(C 1-10 alkyl)OH,

C 1-10 alkoxyC 0-10 alkyl,

cyano,

(C 1-6 alkyl)cyano, and

C 1-6 haloalkyl,

wherein two R 4 together with the ring atom to which each is attached optionally may form a saturated ring;

R 5 is selected from:

halogen,

oxo (═O),

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 2-10 alkenyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 0-10 alkylaminocarbonylC 0-10 alkyl,

C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

(C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

aryl C 0-10 alkylaminoC 0-10 alkyl,

heteroaryl C 0-10 alkylaminoC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkylaminoC 0-10 alkyl,

(C 1-10 alkyl) 1-2 amino,

—SF 5 ,

C 0-10 alkylsulfonyl,

C 1-10 heteroalkylsulfonyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfonyl,

heteroarylC 0-10 alkylsulfonyl,

arylC 0-10 alkylsulfonyl,

C 0-10 alkylsulfamoyl,

C 1-10 heteroalkylsulfamoyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfamoyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfamoyl,

heteroarylC 0-10 alkylsulfamoyl,

C 0-10 alkylsulfonimidoylC 0-10 alkyl,

C 1-10 heteroalkylsulfonimidoylC 0-10 alkyl,

(C 3-12 )cycloalkylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

(C 3-12 )cycloheteroalkylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

heteroarylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

arylC 0-10 alkylsulfonimidoylC 0-10 alkyl,

—SO 2 NH 2 ,

—SO 2 NH(C 1-6 alkyl),

—SO 2 N(C 1-6 alkyl) 2 ,

arylC 0-10 alkylsulfamoyl,

(C 0-10 alkyl) 1-2 amino,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

—SO 2 CH 2 CF 3 ,

C 1-10 alkylsulfinyl,

C 1-4 acylaminoC 0-10 alkyl,

hydroxy,

—(C 1-10 alkyl)OH,

C 1-10 alkoxyC 0-10 alkyl,

cyano,

(C 1-6 alkyl)cyano, and

C 1-6 haloalkyl; and

wherein R 4 and R 5 are each optionally substituted with 1, 2, 3, or 4 R 6 substituents and R 6 is independently selected from:

halogen,

C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 2-10 alkenyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,

C 1-10 alkyl(carbonyl) 0-1 oxyC 0-10 alkyl,

C 2-10 alkenyl(carbonyl) 0-1 oxyC 0-10 alkyl,

C 1-10 heteroalkyl(carbonyl) 0-1 oxyC 0-10 alkyl,

aryl C 0-10 alkyl (carbonyl) 0-1 oxyC 0-10 alkyl,

(C 3-12 )cycloalkyl C 0-10 alkyl(carbonyl) 0-1 oxyC 0-10 alkyl,

heteroarylC 0-10 alkyl(carbonyl) 0-1 oxyC 0-10 alkyl,

(C 3-12 )heterocycloalkyl C 0-10 alkyl(carbonyl) 0-1 oxyC 0-10 alkyl,

((C 0-10 )alkyl) 1-2 aminocarbonyloxy,

aryl (C 0-10 )alkylaminocarbonyloxy,

—CO 2 (C 0-10 alkyl),

—(C 0-10 alkyl)CO 2 H,

oxo (═O),

C 0-10 alkylsulfonyl,

C 1-10 heteroalkylsulfonyl,

(C 3-12 )cycloalkylsulfonyl,

(C 3-12 )cycloheteroalkylsulfonyl,

heteroarylsulfonyl,

arylsulfonyl,

aminosulfonyl,

—SO 2 NH 2 ,

—SO 2 NH(C 1-6 alkyl),

—SO 2 N(C 1-6 alkyl) 2 ,

—SO 2 CF 3 ,

—SO 2 CF 2 H,

C 1-10 alkylsulfinyl,

amino,

(C 1-10 alkyl) 1-2 amino,

-(oxy) 0-1 (carbonyl) 0-1 N(C 0-10 alkyl) 1-2

C 1-4 acylaminoC 0-10 alkyl,

hydroxy,

(C 1-10 alkyl)OH,

C 1-10 alkoxyC 0-10 alkyl,

(C 1-10 alkyl)cyano,

cyano, and

C 1-6 haloalkyl; and

R 6 is optionally substituted with 1, 2, or 3 R 7 substituents selected from hydrogen, hydroxy, (C 1-6 )alkyl, C 1-10 alkoxyC 0-10 alkyl, (C 1-10 alkyl)OH, halogen, CO 2 H, —(C 0-6 )alkylCN, —O(C═O)C 1 -C 6 alkyl, NO 2 , trifluoromethoxy, trifluoroethoxy, trifluoromethyl, trifluoroethyl, —N—C(O)O(C 0-6 )alkyl, C 1-10 alkylsulfonyl, oxo (O═), aminosulfonyl, —SO 2 C 1-6 alkyl, —SO 2 CF 3 , —SO 2 CF 2 H, —C 1-10 alkylsulfinyl, —O (0-1) (C 1-10 )halo, —SO 2 NH 2 , —SO 2 NH(C 1-6 alkyl), —SO 2 N(C 1-6 alkyl) 2 , alkyl, amino(C 1-6 alkyl) 0-2 and NH 2 .

2. A compound according to claim 1 , wherein R 5 is selected from: halogen, oxo (═O), C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, (C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 0-10 alkylaminocarbonylC 0-10 alkyl, C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, (C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, —SF 5 , C 0-10 alkylsulfonyl, C 1-10 heteroalkylsulfonyl, (C 3-12 )cycloalkylC 0-10 alkylsulfonyl, (C 3-12 )cycloheteroalkylC 0-10 alkylsulfonyl, C 0-10 alkylsulfamoyl, (C 3-12 )cycloalkylC 0-10 alkylsulfamoyl, (C 3-12 )cycloheteroalkylC 0-10 alkylsulfamoyl, heteroarylC 0-10 alkylsulfamoyl, C 0-10 alkylsulfonimidoylC 0-10 alkyl, C 1-10 heteroalkylsulfonimidoylC 0-10 alkyl, —SO 2 NH 2 , —SO 2 NH(C 1-6 alkyl), —SO 2 N(C 1-6 alkyl) 2 , arylC 0-10 alkylsulfamoyl, (C 1-10 alkyl) 1-2 amino, —SO 2 CF 3 , —SO 2 CF 2 H, —SO 2 CH 2 CF 3 , hydroxy, —(C 1-10 alkyl)OH, C 1-10 alkoxyC 0-10 alkyl, cyano, (C 1-6 alkyl)cyano, and C 1-6 haloalkyl; wherein R 5 is optionally substituted with 0, 1, 2, 3, or 4 R 6 substituents.

3. A compound according to claim 2 , wherein R 4 is selected from: halogen, oxo (═O), C 1-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl,C 1-10 heteroalkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, aryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 3-12 cycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, heteroaryl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, (C 3-12 )heterocycloalkyl C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 C 0-10 alkyl, C 0-10 alkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, C 1-10 alkylamino(carbonyl) 0-1 C 0-10 alkyl, (C 1-10 )heteroalkyl(oxy) 0-1 (carbonyl) 0-1 aminoC 0-10 alkyl, (C 1-10 )heteroalkylamino(carbonyl) 0-1 C 0-10 alkyl, C 3-12 cycloalkyl C 0-10 alkylaminoC 0-10 alkyl, aryl C 0-10 alkylaminoC 0-10 alkyl, heteroaryl C 0-10 alkylaminoC 0-10 alkyl, (C 3-12 )heterocycloalkyl C 0-10 alkylaminoC 0-10 alkyl, C 0-10 alkylsulfonyl, (C 3-12 )cycloalkylC 0-10 alkylsulfonyl, (C 3-12 )cycloheteroalkylC 0-10 alkylsulfonyl, —SO 2 NH 2 , —SO 2 NH(C 1-6 alkyl), —SO 2 N(C 1-6 alkyl) 2 , C 0-10 alkylsulfonimidoylC 0-10 alkyl, C 1-10 heteroalkylsulfonimidoylC 0-10 alkyl, (C 1-10 alkyl) 1-2 amino, —CO 2 (C 0-10 alkyl), —SO 2 CF 3 , —SO 2 CF 2 H, —SO 2 CH 2 CF 3 , hydroxy, —(C 1-10 alkyl)OH, C 1-10 alkoxyC 0-10 alkyl, cyano, (C 1-6 alkyl)cyano, and C 1-6 haloalkyl, wherein R 4 is optionally substituted with 0, 1, 2, 3, or 4 R 6 substituents, and two R 4 together with the ring atom to which each is attached optionally may form a saturated ring.

4. A compound according to claim 3 , wherein R 4 is selected from tert-butylcarbonyl, methoxycarbonyl, methylcarbonyl, cyclopropylmethyl, cyclopropylmethylcarbonyl, cyclopropylethylcarbonyl, cyclopropylcarbonyl, cyclobutylcarbonyl, cyclopentyloxycarbonyl, isopropyloxycarbonyl, phenylmethyl, phenylpropyl, phenylmethylcarbonyl, phenylethylcarbonyl, phenyloxycarbonyl, phenylcarbonyl, oxazolylmethyl, 1,3-oxazolylmethyl, indolylmethyl, 1-phenylethyl, pyridinylmethyl, cyclohexylcarbonyl, fluoro, 2,2,2-trifluoroethyl, ethyl, 2-hydoxyethyl, neopentylcarbonyl, neopentyloxycarbonyl, ethylcarbonyl, ethyloxycarbonyl, methoxymethylcarbonyl (methylamino)methylcarbonyl, 2,3-dihydro-1H-indenylcarbonyl, pyrrolidinylmethylcarbonyl, tetrahydro-2H-pyranylcarbonyl, tetrahydro-2H-thiopyranyloxycarbonyl, tetrahydro-2H-pyranyloxycarbonyl, 1-(pyridinyl)ethyloxycarbonyl, adamantylcarbonyl, tetrahydrofuranyloxycarbonyl, trifluoroethylsulfonyl, dimethylamino, tert-butyloxycarbonyl, methyl, tert-butylaminocarbonyl, aminocarbonyl, azetidinyl, cyclohexylamino, oxo, hydroxy, methylaminocarbonyl, cyclopropylsulfonyl, methoxy, phenylamino, pyridinyl, hydroxyisopropyl, hydroxyeth-2-yl, trifluoromethyl, 2-(methylthio)eth-2-ylcarbonyl, methylsulfonyl, ethylcarbonyl, methylamino, isopropyloxycarbonyl, and hydroxyisopropyl; wherein R 4 is optionally substituted with 0, 1, 2, 3, or 4 R 6 substituents, and wherein two R 4 together with the ring atom to which each is attached optionally may form a saturated ring.

5. A compound according to claim 4 , wherein embodiment R 5 is selected from: methoxycarbonyl, tert-butylsulfonyl, tert-butylsulfamoyl, tert-butyl(methyl)sulfamoyl, tert-butyl(ethyl)sulfamoyl, pentafluorosulfanyl, methoxy, dimethyamino, oxo, amino, fluoro, isobutyl, isopropyl, sulfamoyl, dimethylsulfamoyl, methylsulfonyl, ethylsulfonyl, trifluoromethylsulfonyl, tert-butyloxycarbonyl(1-methyl)ethyl, diethylsulfamoyl, ethylsulfamoyl, pyrrolidinylsulfonyl, methyl, tert-butylaminomethyl, methylaminocarbonyl, methylaminomethyl, ethyl, (1-hydroxy)ethyl, piperidinylsulfonyl, piperidinyl, thiomorpholinylcarbonyl, thiazolidinylcarbonyl, thiomorpholinylmethyl, pyrrolidinylcarbonyl, piperidinylcarbonyl, ethylaminocarbonyl, morpholinylcarbonyl, tert-butyl, cyclopentylmethyl, cyclohexyl, cyclohexylsulfonyl, cyclohexylsulfamoyl, cyclopentyl, cyclopentylsulfonyl, benzyl, hydroxymethyl, 8-oxa-3-azabicyclo[3.2.1]octanyl, 8-oxa-3-azabicyclo[3.2.1]octane-3carbonyl, 3-oxa-8-azabicyclo[3.2.1]octan-8-ylcarbonyl, ethoxycarbonyl(dimethyleth-2-yl), hydroxy, trifluoromethyl, azetidinylsulfonyl, cyclopropylsulfonyl, cyclopropyl, chloro, ethylaminomethyl, pyrrolidinylmethyl, 1-pyrrolidin-1-ylethyl, cyclopropylmethyl, pyrazolylmethyl, morpholinylsulfonyl, isopropylaminomethyl, pyrazolyl, pyrrolidinyl, piperadinyl, methylsulfonyl, isopropylsulfonyl, isopropylsulfamoyl, methylsulfamoyl, benzylsulfamoyl, cyclopropylmethyl, cyclobutyl, tert-butylsulfonyl, tert-butyloxycarbonyl, tert-butyloxycarbonylmethyl, methoxymethyl, 2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl, methoxyeth-2-yl, triazolylmethyl, 1,2,3-triazolylmethyl, aminomethyl, ethylaminomethyl, aminocarbonyl, morpholinyl, isopropyl, isopropyl(methy)sulfamoyl, sulfonyl, cyano, 2,2,2-trifluoroethyl, ethylaminocarbonyl, tert-butylaminomethyl, isopropyloxycarbonyl(dimethyleth-2-yl), 1,1,1-trifluoro-3,3-dimethylbut-2-yl, (1,1,2-trimethylpropyl)sulfonyl, (1,1-dimethylpropyl)sulfonyl, isopropylsulfonimidoyl methylsulfonyl, ethylcarbonyl, 2,3-dihydro-1H-indenyl, ethylmethylsulfamoyl, neopentyl, methylaminomethyl dimethylamino, 2-(isopropylamino)propan-2-yl, 2,2-dimethylpropyl, hydroxymethyl, hydroxyeth-2-yl, tert-butyloxycarbonyl(2-methylprop-2-yl), methoxy, ethylaminocarbonyl, methylaminocarbonyl, and methoxymethyl; and wherein R 5 is optionally substituted with 0, 1, 2, 3, or 4 R 6 substituents.

6. A compound or a pharmaceutically acceptable salt, or a stereoisomer thereof selected from:

tert-butyl 3-(cyanomethyl)-3-(4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)azetidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-[3-(ethylamino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-{3-[(cyclopropylmethyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-[3-(cyclobutylamino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 3-(cyanomethyl)-3-[3-(ethylamino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]azetidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-[3-(methylamino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 3-(cyanomethyl)-3-[3-(cyclopropylamino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]azetidine-1-carboxylate;

tert-butyl 3-(cyanomethyl)-3-(4-oxo-3-((2-(trifluoromethyl)pyridin-4-yl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)azetidine-1-carboxylate;

tert-butyl 3-(cyanomethyl)-3-(3((4(methoxycarbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)azetidine-1-carboxylate;

tert-butyl 3-(cyanomethyl)-3-(3-((4-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)azetidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-[4-oxo-3-({4-[2,2,2-trifluoro-hydroxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-{4-oxo-3-[(4-sulfamoylphenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-{[1-oxo-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1H-isoindol-5-yl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-3-fluoro-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-{3-[(2-methyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-{[4-(pentafluorosulfanyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-{[4-(trifluoromethyl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-3-fluoro-4-{3-[(2-methyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-3-methyl-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-((1-oxo-2,3-dihydro-1H-inden-5-yl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1- carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-{[3-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-3-fluoro-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-{[4-(dimethylsulfamoyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluoropiperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-3-fluoro-4-[4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-3-fluoro-4-[4-oxo-3-({4-[2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-4-(cyanomethyl)-3-fluoropiperidine-1-carboxylate;

tert-butyl 4-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-{[1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluoropiperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

2-(4-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-1-(2,2-difluoropropanoyl)piperidin-4-yl)acetonitrile;

2-(3-(4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

4-((1-(3-(cyanomethyl)tetrahydro-2H-pyran-3-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

2-(3-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

methyl 5-(cyanomethyl)-5-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 3-(cyanomethyl)-3-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)azetidine-1-carboxylate;

tert-butyl 3-(cyanomethyl)-3-{3-[(2-fluoropyridin-4-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}azetidine-1-carboxylate;

tert-butyl 3-(cyanomethyl)-3-[4-oxo-3-({4-[(trifluoromethyl)sulfonyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]azetidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-{3-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 5-(3-((4-1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

N-(tert-butyl)-4-((1-(4-(cyanomethyl)-1-(2,2-difluoropropanoyl)piperidin-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)benzenesulfonamide;

2-(1-(2,2-difluoropropanoyl)-4-(3-((4-(isopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-4-yl)acetonitrile;

N-(tert-butyl)-4-((1-(4-(cyanomethyl)-1-(2,2-difluoropropanoyl)piperidin-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-methylbenzenesulfonamide;

2-(4-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-1-(2,2-difluoropropanoyl)piperidin-4-yl)acetonitrile;

tert-butyl 4-(3-(3,5-bis((1H-pyrazol-1-yl)methyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-(3,5-dimethylphenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-(3,5-bis((1H-1,2,3-triazol-1-yl)methyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(3-(3,5-bis((2H-1,2,3-triazol-2-yl)methyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(3-(3-((1H-1,2,3-triazol-1-yl)methyl)-5-((2H-1,2,3-triazol-2-yl)methyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(3-(m-toluidino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-(isoindolin-5-ylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl]amino}-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-{[2-(cyclopropylmethyl)-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl]amino}-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-{3-[(2-ethyl-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl)amino]-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-[3-[(2-methyl-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl)amino]-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

methyl 4-{3-[(2-tert-butyl-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl)amino]-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl}-4-(cyanomethyl)piperidine-1-carboxylate;

methyl 4-{3-[(2-ethyl-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl)amino]-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl}-4-(cyanomethyl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-{[2-(2-methylpropyl)-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl]amino}-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-{[2-(cyclopropylmethyl)-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl]amino}-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-{[2-(cyclopentylmethyl)-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl]amino}-4-oxo-1H,4H,5H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-[4-oxo-3-({4-[(trifluoromethyl)sulfonyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-{3-[(2-fluoropyridin-4-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

4-(1-(1-(cyanomethyl)cyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-ylamino)-N,N-dimethylbenzenesulfonamide;

2-(1-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1- yl)cyclohexyl)acetonitrile;

tert-butyl 4-(cyanomethyl)-4-(3-((1,1-dioxido-2,3-dihydrobenzo[b]thiophen-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

2-(8-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-1,4-dioxaspiro[4.5]decan-8-yl)acetonitrile;

4-({1-[1-(cyanomethyl)-2-fluorocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

{2-fluoro-1-[4-oxo-3-({4-[2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexyl}acetonitrile

{2-fluoro-1-[3-({4-[(1-methylethyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexyl}acetonitrile;

2-(1-(3-((4-(1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

tert-butyl 5-(3-((4-(N-(tert-butyl)-N-methylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(N-isopropyl-N-methylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(N-ethyl-N-methylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(N-methylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((1-oxo-2-(2,2,2-trifluoroethyl)isoindolin-5-yl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(3-((4-((1H-1,2,3-triazol-1-yl)methyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(3-((4-((2H-1,2,3-triazol-2-yl)methyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(isopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(cyclopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(3-((2-(tert-butyl)-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-cyclohexyl-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-cyclopentyl-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(3-((4-(1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

[3-(3-{[4-(azetidin-1-ylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

{3-[3-({4-[(3-methylazetidin-1-yl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{3-[3-({4-[(2,2-dimethylpyrrolidin-1-yl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

[3-{3-[(4-{[2-methylazetidin-1-yl]sulfonyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

{3-[4-oxo-3-({4-[2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

ethyl 3-(4-((1-(3-(cyanomethyl)tetrahydro-2H-pyran-3-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)phenyl)-4,4,4-trifluoro-3-hydroxy-2,2-dimethylbutanoate;

2-(3-(3-((4-(3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(3-(3-((4-(3-fluoropyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(3-(3-((4-(3-methoxypyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(3-(3-((3-methyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(3-(3-((1-hydroxy-2,2-dimethyl-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(1-(3-((2-(tert-butyl)-1, 1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

2-(1-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)benzonitrile;

2-(1-(4-oxo-3-((1-oxo-1,3-dihydroisobenzofuran-5-yl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

(1-{3-[(3,3-dimethyl-1-oxo-1,3-dihydro-2-benzofuran-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclopentyl)acetonitrile;

tert-butyl 4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)benzoate;

4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-methylbenzamide;

2-(1-(3-((2-isopropyl-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-isopropylbenzenesulfonamide;

4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-methylbenzenesulfonamide;

2-(1-(3-((4-(azetidin-1-ylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

2-(1-(3-((4-(ethylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

N-(tert-butyl)-4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-methylbenzenesulfonamide;

N-(tert-butyl)-4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-ethylbenzenesulfonamide;

4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-diethylbenzenesulfonamide;

tert-butyl 2-(4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-methylphenylsulfonamido)-2-methylpropanoate;

2-(1-(4-oxo-3-((1-oxo-2-(2,2,2-trifluoroethyl)isoindolin-5-yl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

ethyl 2-(4-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-methylphenylsulfonamido)-2-methylpropanoate;

tert-butyl 2-(5-((1-(1-(cyanomethyl)cyclopentyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-1-oxoisoindolin-2-yl)-2-methylpropanoate;

methyl 4-(cyanomethyl)-4-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-((1-hydroxy-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-((4-cyanophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-((4-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(4-oxo-3-(quinolin-6-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-((4-(isopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

2-(2-fluoro-1-(3-((3-methyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(2-fluoro-1-(3-((2-fluoropyridin-4-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(1-(3-((4-(4,4-difluoropiperidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-2-fluorocyclohexyl)acetonitrile;

2-(2-fluoro-1-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1- yl)cyclohexyl)acetonitrile;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(thiazolidine-3-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(2-methylthiazolidine-3-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(2-methylthiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxy-4-isopropoxy-3,3-dimethyl-4-oxobutan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((1-hydroxy-2,2-dimethyl-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxy-3,3-dimethylbutan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(2,2,2-trifluoro-1-hydroxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(1,1,1-trifluoro-2-methoxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

{1-[3-({4-[1-(ethylamino)-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-fluorocyclohexyl}acetonitrile;

[2-fluoro-1-{3-[(4-{1-methyl-1-[(1-methylethyl)amino]ethyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1- yl}cyclohexyl]acetonitrile;

{1-[3-({4-[1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-fluorocyclohexyl}acetonitrile;

[3-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

{3-[3-({4-[(1-methylethyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

4-({1-[3-(cyanomethyl)-4-fluorotetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

N-tert-butyl-4-({1-[3-(cyanomethyl)tetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-methylbenzenesulfonamide;

[3-(3-{[4-(tert-butylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

N-tert-butyl-4-({1-[3-(cyanomethyl)tetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzenesulfonamide;

tert-butyl[5-({1-[3-(cyanomethyl)tetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]acetate;

tert-butyl 3-{[4-({1-[3-(cyanomethyl)tetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)phenyl]sulfonyl}-3-methylbutanoate;

{3-[3-({4-[1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{3-[3-({4-[1-(tert-butylamino)-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

[3-(3-{[4-(cyclopentylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

{3-[4-oxo-3-({4-[(1,1,2-trimethylpropyl)sulfonyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

[3-(3-{[4-(cyclohexylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

tert-butyl 5-(3-((4-(1-(tert-butylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5- (cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

{3-[3-({4-[(1,1-dimethylpropyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

[3-{3-[(2-cyclopentyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

{3-[4-oxo-3-({4-[2,2,2-trifluoro-1-pyrrolidin-1-ylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{3-[4-oxo-3-({4-[1-pyrrolidin-1-ylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{3-[3-({4-[(2,2-dimethylcyclopentyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(morpholinosulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

[3-(3-{[4-(morpholin-4-ylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

[3-{4-oxo-3-[(4-{2,2,2-trifluoro-1-[(1-methylethyl)amino]ethyl}phenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(1-(ethylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(2,2,2-trifluoro-1-(isopropylamino)ethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(1-(pyrrolidin-1-yl)ethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H- pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(1-(dimethylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-(quinolin-6-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-cyanoquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-methylquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(1H-pyrazol-1-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(2,2-dimethylmorpholine-4-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-(quinolin-3-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-(dimethylamino)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(3-((2-carbamoylquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

2-(3-(4-oxo-3-((4-(1-(trifluoromethyl)cyclopropyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(3-(3-((2-(dimethylamino)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(3-(3-((2-methylquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

tert-butyl 5-(cyanomethyl)-5-(3-((2-morpholinoquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-(2-methylmorpholino)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(3-((2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(propan-2-yl-sulfonimidoyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

2-(3-(4-oxo-3-((4-(propan-2-ylsulfonimidoyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

4-({1-[1-(cyanomethyl)-2-fluorocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

tert-butyl 5-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(cyclopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(isopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-(dimethylcarbamoyl)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

4-({1-[3-(cyanomethyl)tetrahydrofuran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzonitrile;

[3-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

[3-{3-[(4-chloro-8-fluoroquinolin-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

[3-{3-[(4-fluoroquinolin-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

2-(3-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydrofuran-3-yl)acetonitrile;

2-(3-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydrofuran-3-yl)acetonitrile;

2-(4-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

2-(4-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

N-(tert-butyl)-4-((1-(4-(cyanomethyl)tetrahydro-2H-pyran-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N-methylbenzenesulfonamide;

4-((1-(4-(cyanomethyl)tetrahydro-2H-pyran-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

2-(4-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-(3-fluoro-4-(3-(3-methyl-4-(morpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-tetrahydro-2H-pyran-4-yl)acetonitrile;

2-(4-(3-((2-(tert-butyl)-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-(3-fluoro-4-(3-(3-methyl-4-(thiomorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-tetrahydro-2H-pyran-4-yl)acetonitrile;

2-(3-fluoro-4-(4-oxo-3-((4-(2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

2-(4-(3-((4-(1-(tert-butylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-[4-(3-{[1,1-dioxo-2-(piperidin-4-yl)-3H-1,2-benzothiazol-5-yl]amino}-4-oxo-5H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorooxan-4-yl]acetonitrile;

tert-butyl 4-(cyanomethyl)-3-fluoro-4-{3-[(4-{1-methyl-1-[(1-methylethyl)amino]ethyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(2-(isopropylamino)propan-2-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 4-(cyanomethyl)-3-fluoro-4-(3-{[4-(1-methoxyethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-{3-[(4-{1-methyl-1-[(1-methylethyl)amino]ethyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

2-(4-(3-((1,1-dioxido-2-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

tert-butyl 4-(cyanomethyl)-3-fluoro-4-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-((4-(1-benzyl-3-(trifluoromethyl)pyrrolidin-3-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-((4-(3-(trifluoromethyl)pyrrolidin-3-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(3-(trifluoromethyl)pyrrolidin-3-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-((4-(((2,2,2-trifluoroethyl)amino)methyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(N-isopropylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(3-((4-(N-benzylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(N-(cyclopropylmethyl)sulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(N-(2-methoxyethyl)sulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(N-cyclohexylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-((4-(piperidin-1-ylsulfonyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1- carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(morpholinosulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((3-fluoro-4-(N-isopropylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(N-(cyclopropylmethyl)sulfamoyl)-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(4-{3-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidin-4-yl)acetonitrile;

[1-(cyclopropylcarbonyl)-4-{3-[(4-fluorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidin-4-yl]acetonitrile;

4-({1-[1-benzyl-4-(cyanomethyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(4-methylbenzyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-[(1-{4-(cyanomethyl)-1-[4-(trifluoromethyl)benzyl]piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzenesulfonamide;

4-[(1-{4-(cyanomethyl)-1-[4-(1-methylethyl)benzyl]piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzenesulfonamide;

4-[(1-{4-(cyanomethyl)-1-[4-(1-methylethyl)benzyl]piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzene sulfonamide;

4-[(1-{4-(cyanomethyl)-1-[4-(1methylethoxy)benzyl]piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzene sulfonamide;

4-({1-[4-(cyanomethyl)-1-(4-fluorobenzyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(3-fluorobenzyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzene sulfonamide;

4-({1-[4-(cyanomethyl)-1-(2-fluorobenzyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(2,6-difluorobenzyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzene sulfonamide;

4-({1-[4-(cyanomethyl)-1-(2,3,6-trifluorobenzyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(1,3-oxazol-2-ylmethyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(4-isoxazol-3-ylbenzyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-[(1-{4-(cyanomethyl)-1-[4-(2-oxopyrrolidin-1-yl)benzyl]piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3- yl)amino]-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(3-phenylpropyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzene sulfonamide;

4-({1-[4-(cyanomethyl)-1-(1H-indol-4-ylmethyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-((1-(4-(cyanomethyl)-1-(1-(2,6-difluorophenyl)ethyl)piperidin-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

4-((1-(4-(cyanomethyl)-1-phenethylpiperidin-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

3-({1-[4-(cyanomethyl)-1-(pyridin-3-ylmethyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-propanoylpiperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(3,3,3-trifluoropropanoyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(methoxyacetyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(N,N-dimethylglycyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(2,2-dimethylpropanoyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(cyclopropylcarbonyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-[(1-{4-(cyanomethyl)-1-[(3,3-difluorocyclobutyl)carbonyl]piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(cyclohexylcarbonyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-[(1-{4-(cyanomethyl)-1-[tricyclo[3.3.1.13,7]dec-1-ylcarbonyl]piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(cyclopropylacetyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(3-cyclopropylpropanoyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(phenylcarbonyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-[(1-{1-[(4-chlorophenyl)carbonyl]-4-(cyanomethyl)piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzenesulfonamide;

4-[(1-{1-[(3-chlorophenyl)carbonyl]-4-(cyanomethyl)piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzenesulfonamide;

4-[(1-{1-[(2-chlorophenyl)carbonyl]-4-(cyanomethyl)piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-{[4-(trifluoromethyl)phenyl]acetyl}piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(3-phenylpropanoyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(2,3-dihydro-1H-inden-2-ylcarbonyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-[(1-{4-(cyanomethyl)-1-[(2-oxopyrrolidin-1-yl)acetyl]piperidin-4-yl}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino]-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(tetrahydro-2H-pyran-4-ylcarbonyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(4,4,4-trifluorobutanoyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(3-cyanopropanoyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[4-(cyanomethyl)-1-(3,3-dimethylbutanoyl)piperidin-4-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-((1-(4-(cyanomethyl)-1-(2-(methylthio)propanoyl)piperidin-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

4-((1-(1-(2-cyanoacetyl)-4-(cyanomethyl)piperidin-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

methyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

phenyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

4-fluorophenyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

neopentyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

ethyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

isopropyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

2-methylcyclopentyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

2-(methylthio)ethyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tetrahydro-2H-thiopyran-4-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

1-methoxypropan-2-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tetrahydrofuran-3-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tetrahydro-2H-pyran-4-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

1,1,1-trifluoropropan-2-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

1-(pyridin-2-yl)ethyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

1-cyanoethyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tetrahydrofuran-3-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

2,2,2-trifluoroethyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

isopropyl-4-(cyanomethyl)-4-(3-(2-fluoropyridin-4-ylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

methyl 4-(cyanomethyl)-4-(3-(2-fluoropyridin-4-ylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

4-((1-(4-(cyanomethyl)-1-((2,2,2-trifluoroethyl)sulfonyl)piperidin-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

4-((1-(4-(cyanomethyl)-1-(cyclopropylsulfonyl)piperidin-4-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

2-(4-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-1-(4-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)acetonitrile;

6-(4-(cyanomethyl)-4-(3-((4(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1-yl)nicotinonitrile;

6-(4-(cyanomethyl)-4-(3-((4((difluoromethyl)sulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1-yl)nicotinonitrile;

2-(4-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-1-(5(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)acetonitrile;

6-(4-(cyanomethyl)-4-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1-yl)nicotinonitrile;

6-((3R,4R)-4-(cyanomethyl)-3-fluoro-4-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-1-yl)nicotinonitrile;

2-(1-(5-iodopyridin-2-yl)-4-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-4-yl)acetonitrile;

2-(1-(5-bromopyridin-2-yl)-4-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-4-yl)acetonitrile;

2-(4-(3-(3-methyl-4-(thiomorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-1-(4-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)acetonitrile;

(R or S)-2-(4-(4-oxo-3-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-1-(4-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)acetonitrile;

2-(4-(3-(4-(4,4-difluoropiperidine-1-carbonyl)-3-methylphenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-1-(4-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)acetonitrile;

2-(1-(2,2-difluoropropanoyl)-4-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidin-4-yl)acetonitrile;

2-(4-(3-fluoroazetidin-1-yl)-1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

2-(4-hydroxy-1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)acetonitrile;

2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-methoxyazetidin-1-yl)cyclohexyl)acetonitrile;

2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)acetonitrile;

2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-hydroxycyclohexyl)acetonitrile;

2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

2-(4-(3-methoxyazetidin-1-yl)-1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

2-(4-(cyclohexylamino)-1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(cyclohexylamino)cyclohexyl)acetonitrile;

2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-methoxyazetidin-1-yl)cyclohexyl)acetonitrile;

2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

2-(1-(3-((4-((difluoromethyl)sulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)acetonitrile;

4-((1-(1-(cyanomethyl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

2-(4-(3-fluoroazetidin-1-yl)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(4-(dimethylamino)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo-[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(4-(3-fluoroazetidin-1-yl)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-(1-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(dimethylamino)cyclohexyl)acetonitrile;

4-((1-(1-(cyanomethyl)-4-oxocyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

N-(tert-butyl)-5-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxamide;

N-tert-butyl-5-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-5-(cyanomethyl)-N-methyltetrahydro-2H-pyran-2-carboxamide;

isopropyl 5-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

2-(3-(3-((4-(4,4-difluoropiperidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(3-(3-((3-methyl-4-(2-methylpiperidine-1-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-(3-(3-((4-(4-hydroxy-4-methylpiperidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(pyrrolidine-1-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(3-methylmorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(2-methylmorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(2,6-dimethylmorpholine-4-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((4-(ethyl(2,2,2-trifluoroethyl)carbamoyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(methyl(2,2,2-trifluoroethyl)carbamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(3-((4-(2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(3-((2-methylbenzo[d]thiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

[1-{3-[(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-2-fluorocyclohexyl]acetonitrile;

tert-butyl 5-(cyanomethyl)-5-(3-((3,3-dimethyl-2-oxoindolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

[3-{3-[(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

[3-{3-[(2-methyl-1,3-benzothiazol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

tert-butyl 5-(cyanomethyl)-5-(3-((2-fluoropyridin-4-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(2,2,2-trifluoro-1-methoxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-((4-(4,4-difluoropiperidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl-4-(3-((4-(8-oxa-3-azabicyclo[3.2.1]octane-3-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-{3-[(5-methyl-4-{3-oxa-8-azabicyclo[3.2.1]octan-8-ylcarbonyl}cyclohexa-1,3,5-trien-1-yl)amino]-4-oxo-5H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl-4-(cyanomethyl)-4-(3-(3-methyl-4-(thiomorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl-4-(cyanomethyl)-4-(3-((1,1-dioxido-2-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-(4-(2-(trifluoromethyl)piperidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-(4-(2-(trifluoromethyl)pyrrolidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-(3-(3-methyl-4-(morpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

5-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)-N-(methylsulfonyl)tetrahydro-2H-pyran-2-carboxamide;

5-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)-N,N-dimethyltetrahydro-2H-pyran-2-carboxamide; and

2-(3-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-6-(2-hydroxypropan-2-yl)tetrahydro-2H-pyran-3-yl)acetonitrile.

7. A pharmaceutical composition comprising a compound of claim 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

8. A pharmaceutical composition comprising a compound of claim 6 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

9. A compound according to claim 6 , or a pharmaceutically acceptable salt, selected from:

tert-butyl 4-(cyanomethyl)-4-[4-oxo-3-({4-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-[4-oxo-3-({4-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-3-fluoro-4-{3-[(2-methyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

tert-butyl (3R,4S)-4-(cyanomethyl)-3-methyl-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-3-methyl-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl (3S,4R)-4-(cyanomethyl)-3-fluoro-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl (3R,4S)-4-(cyanomethyl)-3-fluoro-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl (3S,4S)-4-(cyanomethyl)-3-fluoro-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-3-fluoro-4-(3-{[4-(methylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-4-(3-{[4-(dimethylsulfamoyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluoropiperidine-1-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-3-fluoro-4-[4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-3-fluoro-4-[4-oxo-3-({4-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-3-fluoro-4-[4-oxo-3-({4-[(1R)-2,2,2-trifluoro-1-hydroxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl (3R,4R)-4-{3-[(2-tert-butyl-1,1-di oxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-4-(cyanomethyl)-3-fluoropiperidine-1-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-4-(3-{[1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydro-1,2-benzisothiazol-5-yl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluoropiperidine-1-carboxylate;

(S)-2-(3-(4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(S)-4-((1-(3-(cyanomethyl)tetrahydro-2H-pyran-3-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

(R)-4-((1-(3-(cyanomethyl)tetrahydro-2H-pyran-3-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

(R)-2-(3-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(S)-2-(3-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(2S,5S)-methyl 5-(cyanomethyl)-5-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2R,5R)-methyl 5-(cyanomethyl)-5-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2R,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl -(cyanomethyl)-5-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2R,5R)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(methylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2R,5R)-tert-butyl 5-(3-((2-(tert-butyl)-1,1-dioxido-2, 3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-y 1)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((1,1-dioxido-2-(2,2,2-trifluoroethyl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2R,5S)-tert-butyl 5-(3-((4-((R)-1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((4-((R)-1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2R,5S)-tert-butyl 5-(3-((4-((S)-1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((4-((S)-1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl-(cyanomethyl)-5-(4-oxo-3-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl5-(cyanomethyl)-5-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

4-({1-[(1R,2R))-1-(cyanomethyl)-2-fluorocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

{(1R,2R)-2-fluoro-1-[4-oxo-3-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexyl}acetonitrile;

{(1R,2R)-2-fluoro-1-[4-oxo-3-({4-[(1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexyl}acetonitrile;

{(1R,2R)-2-fluoro-1-[3-({4-[(1-methylethyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]cyclohexyl}acetonitrile;

(R)-2-(1-(3-((4-(1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

(S)-2-(1-(3-((4-(1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclopentyl)acetonitrile;

(2S,5S)-tert-butyl 5-(3-((4-(N-(tert-butyl)-N-methylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl -(cyanomethyl)-5-(3-((4-(N-isopropyl-N-methylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl -(cyanomethyl)-5-(3-((4-(N-ethyl-N-methylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(N-methylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((1-oxo-2-(2,2,2-trifluoroethyl)isoindolin-5-yl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((4-((1H-1,2,3-triazol-1-yl)methyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((4-((2H-1,2,3-triazol-2-yl)methyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(isopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(cyclopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((2-(tert-butyl)-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-cyclohexyl-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-cyclopentyl-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((4-(1-amino-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

[(3S)-3-(3-{[4-(azetidin-1-ylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

{(3S)-3-[3-({4-[(3-methylazetidin-1-yl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{(3S)-3-[3-({4-[(2,2-dimethylpyrrolidin-1-yl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

[(3S)-3-{3-[(4-{[(2R)-2-methylazetidin-1-yl]sulfonyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

[(3S)-3-{3-{[(4-[(2S)-2-methylazetidin-1-yl]sulfonyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

{(3S)-3-[4-oxo-3-({4-[(1S)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{(3S)-3-[4-oxo-3-({4-[(1R)-2,2,2-trifluoro-1-hydroxy-1-methylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

(S)-ethyl 3-(4-((1-((3S)-3-(cyanomethyl)tetrahydro-2H-pyran-3-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)phenyl)-4,4,4-trifluoro-3-hydroxy-2,2-dimethylbutanoate;

(R)-ethyl 3-(4-((1-((3S)-3-(cyanomethyl)tetrahydro-2H-pyran-3-yl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)phenyl)-4,4,4-trifluoro-3-hydroxy-2,2-dimethylbutanoate;

2-((S)-3-(3-((4-((S)-3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((S)-3-(3-((4-((R)-3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((S)-3-(3-((4-((R)-3-fluoropyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((S)-3-(3-((4-((S)-3-methoxypyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((S)-3-(3-((4-((R)-3-methoxypyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(S)-2-(3-(3-((3-methyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((S)-3-(3-(((S)-1-hydroxy-2,2-dimethyl-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((S)-3-(3-(((R)-1-hydroxy-2,2-dimethyl-1-(trifluoromethyl)-2, 3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(R)-methyl 4-(cyanomethyl)-4-(4-oxo-3-((4-(1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-methyl 4-(cyanomethyl)-4-(4-oxo-3-((4-(1,1, 1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-methyl 4-(cyanomethyl)-4-(3-((1-hydroxy-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-methyl 4-(cyanomethyl)-4-(3-((1-hydroxy-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

2-((1R,2R)-2-fluoro-1-(3-((3-methyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-((1R,2R)-2-fluoro-1-(3-((2-fluoropyridin-4-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

2-((1R,2R)-1-(3-((4-(4,4-difluoropiperidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-2-fluorocyclohexyl)acetonitrile;

2-((1R,2R)-2-fluoro-1-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(thiazolidine-3-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-((R)-2-methylthiazolidine-3-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-((S)-2-methylthiazolidine-3-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-((S)-2-methylthiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-((R)-2-methylthiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-((S)-3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-((R)-3-hydroxy-3-(trifluoromethyl)pyrrolidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((S)-1,1,1-trifluoro-2-hydroxy-4-isopropoxy-3,3-dimethyl-4-oxobutan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((R)-1,1,1-trifluoro-2-hydroxy-4-isopropoxy-3,3-dimethyl-4-oxobutan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-(((S)-1-hydroxy-2,2-dimethyl-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-(((R)-1-hydroxy-2,2-dimethyl-1-(trifluoromethyl)-2,3-dihydro-1H-inden-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((S)-1,1,1-trifluoro-2-hydroxy-3,3-dimethylbutan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((R)-1,1,1-trifluoro-2-hydroxy-3,3-dimethylbutan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((S)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((R)-2,2,2-trifluoro-1-hydroxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((S)-1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((R)-1,1,1-trifluoro-2-hydroxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((S)-1,1,1-trifluoro-2-methoxypropan-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

{(1R,2R)-1-[3-({4-[(1R)-1-(ethylamino)-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-fluorocyclohexyl}acetonitrile;

{(1R,2R)-1-[3-({4-[(1S)-1-(ethylamino)-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-fluorocyclohexyl}acetonitrile;

[(1R,2R)-2-fluoro-1-{3-[(4-{1-methyl-1-[(1-methylethyl)amino]ethyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}cyclohexyl]acetonitrile;

{(1R,2R)-1-[3-({4-[(1R)-1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-fluorocyclohexyl}acetonitrile;

{(1R,2R)-1-[3-({4-[(1S)-1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]-2-fluorocyclohexyl}acetonitrile;

[(3S)-3-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

{(3S)-3-[3({4-[(1-methylethyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

4-({1-[(3R,4S)-3-(cyanomethyl)-4-fluorotetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

4-({1-[(3S,4R)-3-(cyanomethyl)-4-fluorotetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

N-tert-butyl-4-({1-[(3S)-3-(cyanomethyl)tetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N-methylbenzenesulfonamide;

[(3S)-3-(3-{[4-(tert-butylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

N-tert-butyl-4-({1-[(3S)-3-(cyanomethyl)tetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzenesulfonamide;

tert-butyl [5-({1-[(3S)-3-(cyanomethyl)tetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-1,1-dioxido-1,2-benzisothiazol-2(3H)-yl]acetate;

tert-butyl 3-{[4-({1-[(3S)-3-(cyanomethyl)tetrahydro-2H-pyran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)phenyl]sulfonyl}-3-methylbutanoate;

{(3S)-3-[3-({4-[(1R)-1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{(3S)-3-[3-({4-[(1S)-1-amino-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{(3S)-3-(3-({[4-[(1R)-1-(tert-butylamino)-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{(3S)-3-[3-({4-[(1S)-1-(tert-butylamino)-2,2,2-trifluoroethyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

[(3S)-3-(3-{[4-(cyclopentylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

{(3S)-3-[4-oxo-3-({4-[(1,1,2-trimethylpropyl)sulfonyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

[(3S)-3-(3-{[4-(cyclohexylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

(2S,5S)-tert-butyl 5-(3-((4-((R)-1-(tert-butylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((4-((S)-1-(tert-butylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

{(3S)-3-[3-({4-[(1,1-dimethylpropyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

[(3S)-3-{3[(2-cyclopentyl-1-oxo-2,3-dihydro-1H-isoindol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

{(3S)-3-[4-oxo-3-({4-[(1R)-2,2,2-trifluoro-1-pyrrolidin-1-ylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{(3S)-3-[4-oxo-3-({4-[(1S)-1-pyrrolidin-1-ylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{(3S)-3-[4-oxo-3-({4-[(1R)-1-pyrrolidin-1-ylethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

{(3S)-3-[3-({4-[(2,2-dimethylcyclopentyl)sulfonyl]phenyl}amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]tetrahydro-2H-pyran-3-yl}acetonitrile;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(morpholinosulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

[(3S)-3-(3-{[4-(morpholin-4-ylsulfonyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl]acetonitrile;

[(3S)-3-{4-oxo-3-[(4-{(1R)-2,2,2-trifluoro-1-[(1-methylethyl)amino]ethyl}phenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

[(3S)-3-{4-oxo-3-[(4-{(1S)-2,2,2-trifluoro-1-[(1-methylethyl)amino]ethyl}phenyl)amino]-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-((R)-1-(ethylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-((S)-1-(ethylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((R)-2,2,2-trifluoro-1-(isopropylamino)ethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((S)-2,2,2-trifluoro-1-(isopropylamino)ethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((S)-1-(pyrrolidin-1-yl)ethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((R)-1-(pyrrolidin-1-yl)ethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-((R)-1-(dimethylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-((S)-1-(dimethylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-(quinolin-6-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-cyanoquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-methylquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(3,5-dimethyl-1H-pyrazol-1-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(1H-pyrazol-1-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(2,2-dimethylmorpholine-4-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-(quinolin-3-ylamino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-(dimethylamino)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((2-carbamoylquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(S)-2-(3-(4-oxo-3-((4-(1-(trifluoromethyl)cyclopropyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(S)-2-(3-(3-((2-(dimethylamino)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(S)-2-(3-(3-((2-methylquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-morpholinoquinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-((S)-2-methylmorpholino)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((2-(8-oxa-3-azabicyclo[3.2.1]octan-3-yl)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(propan-2-yl-(S)-sulfonimidoyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-(propan-2-yl-(R)-sulfonimidoyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

2-((3S)-3-(4-oxo-3-((4-(propan-2-yl-(S)-sulfonimidoyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((3S)-3-(4-oxo-3-((4-(propan-2-yl-(R)-sulfonimidoyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

4-({1-[(1R,2R)-1-(cyanomethyl)-2-fluorocyclohexyl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)-N,N-dimethylbenzenesulfonamide;

(2S,5S)-tert-butyl 5-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(cyclopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(isopropylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-(dimethylcarbamoyl)quinolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

4-({1-[(3R)-3-(cyanomethyl)tetrahydrofuran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzonitrile;

4-({1-[(3S)-3-(cyanomethyl)tetrahydrofuran-3-yl]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl}amino)benzonitrile;

[(3R)-3-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

[(3S)-3-{3-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

[(3R)-3-{3-[(4-chloro-8-fluoroquinolin-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

[(3S)-3-{3-[(4-chloro-8-fluoroquinolin-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

[(3R)-3-{3-[(4-fluoroquinolin-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

[(3S)-3-{3-[(4-fluoroquinolin-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydrofuran-3-yl]acetonitrile;

(S)-2-(3-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydrofuran-3-yl)acetonitrile;

(R)-2-(3-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydrofuran-3-yl)acetonitrile;

(S)-2-(3-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydrofuran-3-yl)acetonitrile;

(R)-2-(3-(3-((4-(tert-butylsulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydrofuran-3-yl)acetonitrile;

2-((3S,4S)-4-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3R,4R)-4-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3S,4S)-3-fluoro-4-(3-(3-methyl-4-(morpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3R,4R)-3-fluoro-4-(3-((3-methyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3R,4R)-4-(3-((2-(tert-butyl)-1-oxoisoindolin-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3S,4S)-4-(3-(2-tert-butyl-1-oxoisoindolin-5-ylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-3-fluoro-tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3S,4S)-3-fluoro-4-(3-(3-methyl-4-(thiomorpholine-4-carbonyl)phenylamino)-4-oxo-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3R,4R)-3-fluoro-4-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3S,4S)-3-fluoro-4-(4-oxo-3-((4-((S)-2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3S,4S)-3-fluoro-4-(4-oxo-3-((4-((R)-2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3R,4R)-3-fluoro-4-(4-oxo-3-((4-((S)-2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3R,4R)-3-fluoro-4-(4-oxo-3((4-((R)-2-(trifluoromethyl)piperidin-2-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3S,4S)-4-(3-((4-((R)-1-(tert-butylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3S,4S)-4-(3-((4-((S)-1-(tert-butylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3R,4R)-4-(3-((4-((R)-1-(tert-butylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3R,4R)-4-(3-((4-((S)-1-(tert-butylamino)-2,2,2-trifluoroethyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-[(3S,4S)-4-(3-{[1,1-dioxo-2-(piperidin-4-yl)-3H-1,2-benzothiazol-5-yl]amino}-4-oxo-5H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorooxan-4-yl]acetonitrile;

2-((3R,4R)-4-(3-((1,1-dioxido-2-(piperidin-4-yl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

tert-butyl (3R,4R)-4-(cyanomethyl)-3-fluoro-4-{3-[(4-{1-methyl-1-[(1-methylethyl)amino]ethyl}phenyl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}piperidine-1-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-(2-(isopropylamino)propan-2-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl (3R,4R)-4-(cyanomethyl)-3-fluoro-4-(3-{[4-(1-methoxyethyl)phenyl]amino}-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

2-((3R,4R)-4-(3-((1,1-dioxido-2-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

2-((3S,4S)-4-(3-((1,1-dioxido-2-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-3-fluorotetrahydro-2H-pyran-4-yl)acetonitrile;

(3R,4R)-tert-butyl 4-(cyanomethyl)-3-fluoro-4-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R) tert-butyl 4-(3-((4-(1-benzyl-3-(trifluoromethyl)pyrrolidin-3-yl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(cyanomethyl)piperidine-1-carboxylate;

(S) tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-((4-(3-(trifluoromethyl)pyrrolidin-3-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((R)-3-(trifluoromethyl)pyrrolidin-3-yl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(trans)-2-methylcyclopentyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tetrahydrofuran-3-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-tetrahydrofuran-3-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(trans)-2-methylcyclopentyl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tetrahydrofuran-3-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-tetrahydrofuran-3-yl 4-(cyanomethyl)-4-(3-((4-(N,N-dimethylsulfamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-2-(4-(4-oxo-3-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-1-(4-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)acetonitrile;

(S)-2-(4-(4-oxo-3-(4-(2,2,2-trifluoro-1-hydroxyethyl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)-1-(4-(trifluoromethyl)pyridin-2-yl)piperidin-4-yl)acetonitrile;

(cis) 2-(4-(3-fluoroazetidin-1-yl)-1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

(trans) 2-(4-(3-fluoroazetidin-1-yl)-1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

cis 2-(1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

trans 2-(1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

(cis) 2-(4-hydroxy-1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

(trans) 2-(4-hydroxy-1-(4-oxo-3-((4-(trifluoromethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

trans 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)acetonitrile;

cis 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)acetonitrile;

trans 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-methoxyazetidin-1-yl)cyclohexyl)acetonitrile;

cis 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-methoxyazetidin-1-yl)cyclohexyl)acetonitrile;

cis 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)acetonitrile;

trans 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-((2,2,2-trifluoroethyl)amino)cyclohexyl)acetonitrile;

cis 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-hydroxycyclohexyl)acetonitrile;

trans 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-hydroxycyclohexyl)acetonitrile;

cis 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

trans 2-(1-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

cis 2-(4-(3-methoxyazetidin-1-yl)-1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

trans 2-(4-(3-methoxyazetidin-1-yl)-1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

cis 2-(1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

trans 2-(1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

trans 2-(4-(cyclohexylamino)-1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

cis 2-(4-(cyclohexylamino)-1-(4-oxo-3-((4-(trifluoromethoxy)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

trans 2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(cyclohexylamino)cyclohexyl)acetonitrile;

cis 2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(cyclohexylamino)cyclohexyl)acetonitrile;

cis 2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-methoxyazetidin-1-yl)cyclohexyl)acetonitrile;

trans 2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-methoxyazetidin-1-yl)cyclohexyl)acetonitrile;

cis 2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

trans 2-(1-(3-((4-chloro-3-fluorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(phenylamino)cyclohexyl)acetonitrile;

cis 2-(1-(3-((4-((difluoromethyl)sulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)acetonitrile;

trans 2-(1-(3-((4-((difluoromethyl)sulfonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)acetonitrile;

trans 4-((1-(1-(cyanomethyl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

cis 4-((1-(1-(cyanomethyl)-4-(3-fluoroazetidin-1-yl)cyclohexyl)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-3-yl)amino)-N,N-dimethylbenzenesulfonamide;

cis 2-(4-(3-Fluoroazetidin-1-yl)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

trans 2-(4-(3-Fluoroazetidin-1-yl)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

cis 2-(4-(dimethylamino)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo-[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

trans 2-(4-(dimethylamino)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo-[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

trans 2-(4-(3-fluoroazetidin-1-yl)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

cis 2-(4-(3-fluoroazetidin-1-yl)-1-(3-((2-methyl-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)cyclohexyl)acetonitrile;

trans 2-(1-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(dimethylamino)cyclohexyl)acetonitrile;

cis 2-(1-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-4-(dimethylamino)cyclohexyl)acetonitrile;

(2S,5S)-N-(tert-butyl)-5-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxamide;

(2S,5S)-N-tert-butyl-5-{3-[(2-tert-butyl-1,1-dioxido-2,3-dihydro-1,2-benzisothiazol-5-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-5-(cyanomethyl)-N-methyltetrahydro-2H-pyran-2-carboxamide;

(2S,5S)-isopropyl 5-(3-((2-(tert-butyl)-1,1-dioxido-2,3-dihydrobenzo[d]isothiazol-5-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(S)-2-(3-(3-((4-(4,4-difluoropiperidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((S)-3-(3-((3-methyl-4-((S)-2-methylpiperidine-1-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

2-((S)-3-(3-((3-methyl-4-((R)-2-methylpiperidine-1-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(S)-2-(3-(3-((4-(4-hydroxy-4-methylpiperidine-1-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-3-yl)acetonitrile;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(morpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(thiomorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(pyrrolidine-1-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-((S)-3-methylmorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-((R)-3-methylmorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-((S)-2-methylmorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-((R)-2-methylmorpholine-4-carbonyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-((2S,6S)-2,6-dimethylmorpholine-4-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((4-((2R,6R)-2,6-dimethylmorpholine-4-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3-methyl-4-(methyl(2,2,2-trifluoroethyl)carbamoyl)phenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(3-((4-((1S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-carbonyl)-3-methylphenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-methylbenzo[d]thiazol-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

[(1R,2R)-1-{3-[(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}-2-fluorocyclohexyl]acetonitrile;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((3,3-dimethyl-2-oxoindolin-6-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

[(3S)-3-{3-[(3,3-dimethyl-2-oxo-2,3-dihydro-1H-indol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

[(3S)-3-{3-[(2-methyl-1,3-benzothiazol-6-yl)amino]-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl}tetrahydro-2H-pyran-3-yl]acetonitrile;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(3-((2-fluoropyridin-4-yl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((R)-2,2,2-trifluoro-1-methoxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

(2S,5S)-tert-butyl 5-(cyanomethyl)-5-(4-oxo-3-((4-((S)-2,2,2-trifluoro-1-methoxyethyl)phenyl)amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)tetrahydro-2H-pyran-2-carboxylate;

tert-butyl 4-(cyanomethyl)-4-[4-oxo-3-({4-[(1R)-2,2,2-trifluoro-1-methoxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

tert-butyl 4-(cyanomethyl)-4-[4-oxo-3-({4-[(1S)-2,2,2-trifluoro-1-methoxyethyl]phenyl}amino)-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl]piperidine-1-carboxylate;

(S)-tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-(4-(2-(trifluoromethyl)piperidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-(4-(2-(trifluoromethyl)piperidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(R)-tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-(4-(2-(trifluoromethyl)pyrrolidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(S)-tert-butyl 4-(cyanomethyl)-4-(4-oxo-3-(4-(2-(trifluoromethyl)pyrrolidin-2-yl)phenylamino)-4,5-dihydropyrazolo[4,3-c]pyridin-1-yl)piperidine-1-carboxylate;

(2S,5S)-5-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-5-(cyanomethyl)-N-(methylsulfonyl)tetrahydro-2H-pyran-2-carboxamide; or

2-((3S,6S)-3-(3-((4-chlorophenyl)amino)-4-oxo-4,5-dihydro-1H-pyrazolo[4,3-c]pyridin-1-yl)-6-(2-hydroxypropan-2-yl)tetrahydro-2H-pyran-3-yl)acetonitrile.

Assignments (3)

MERGER Recorded Aug 8, 2022

From: MERCK SHARP & DOHME CORP.

To: MERCK SHARP & DOHME LLC

Reel/Frame 061102/0145 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2016

From: BAI, YUNFENG; KONG, NORMAN; LIU, YUMEI; ZHENG, ZHIXIANG

To: PHARMARON BEIJING CO., LTD.

Reel/Frame 038319/0140 →

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2016

From: CHILDERS, MATTHEW LLOYD; FULLER, PETER; GUERIN, DAVID; KATZ, JASON DAVID; PU, QINGLIN; SCOTT, MARK E.; THOMPSON, CHRISTOPHER F.; MARTINEZ, MICHELLE; FALCONE, DANIELLE; TORRES, LUIS; DENG, YONGQI; KURUKULASURIYA, RAVI; ZENG, HONGBO; PHARMARON BEIJING CO., LTD.

To: MERCK SHARP & DOHME CORP.

Reel/Frame 038319/0676 →