Compositions and method for treating thrombosis
View Patent ↗A peptide, derivative or peptidomimetic that blocks binding of GNA12 to αSNAP is provided as are methods of using the same to inhibit thrombin-induced von Willebrand Factor secretion and prevent or treat thrombosis.
1. A peptide comprising the sequence Arg-Cys-Leu-Leu-Pro-Ala (SEQ ID NO:1), or a derivative or peptidomimetic thereof, wherein said peptide is less than 45 amino acid residues in length.
2. The peptide of claim 1 , wherein the derivative comprises a post-translation modification selected from the group consisting of acetylation, amidation, formylation, hydroxylation, methylation, myristoylation, phosphorylation, sulfatation, glycosylation, and lipidation.
3. The peptide of claim 1 , wherein said peptide is 6 to 15 amino acid residues in length.
4. A pharmaceutical composition comprising the peptide, derivative or peptidomimetic of claim 1 in admixture with a pharmaceutically acceptable carrier.
5. A method of inhibiting thrombin-induced von Willebrand Factor secretion comprising contacting an endothelial cell with the peptide of claim 1 thereby inhibiting thrombin-induced von Willebrand Factor secretion.
6. A method for preventing or treating thrombosis in a subject comprising administering to a subject in need of treatment the pharmaceutical composition of claim 4 , thereby preventing or treating thrombosis in the subject.