Granted Patent
B2
US 9,884,842 · App. 14/785,381 · Granted Feb 6, 2018
Combretastatin analogs
Inventors:
Narsimha Reddy Penthala (Little Rock, AR); Peter Crooks (Little Rock, AR); Vijayakumar Sonar (Little Rock, AR)
Assignee:
BIOVENTURES, LLC
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Abstract
The present invention relates novel heterocyclic analogs of combretastatin, their synthesis, and their use as anti-cancer compounds. In particular, compounds of Formula (I), Formula (II), and Formula (V) are provided.
Claims (3)
1. A compound selected from the group consisting of:
wherein the compound has a 50% growth inhibition (GI 50 ) value of less than 100 μm when incubated in vitro with human cancer cell line cultures.
2. A compound of claim 1 in combination with at least one pharmaceutically acceptable excipient.
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 31, 2017
From: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
To: BIOVENTURES, LLC
Reel/Frame 041137/0734 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Dec 10, 2015
From: PENTHALA, NARSIMHA REDDY; CROOKS, PETER; SONAR, VIJAYAKUMAR
To: BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS
Reel/Frame 037264/0803 →
Continuity (4)
Provisional Application
61814028
· Apr 19, 2013
Provisional Application
61866878
· Aug 16, 2013
Provisional Application
61901710
· Nov 8, 2013