IP Library Granted Patent US 10,098,608
Granted Patent B2
US 10,098,608 · App. 14/786,484 · Granted Oct 16, 2018

Information processing apparatus for calculating index for supporting diagnosis of subject

Inventors: Kenichi Nakajima (Kanazawa, JP); Koichi Okuda (Matsusaka, JP); Tetsuo Hosoya (Chuo-ku, JP); Yumiko Kirihara (Chuo-Ku, JP); Takehiro Ishikawa (Chuo-ku, JP)
Assignee: Fujifilm RI Pharma Co., Ltd.
A61B6/583A61B6/037A61B6/4258A61B6/469A61B6/481A61B6/503A61B6/5211A61B6/5217A61K51/0406G06F19/00G06F19/321G16H50/20A61B6/5294A61B8/0883G16H50/30
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Quick Facts
Patent No.
US 10,098,608
App. No.
14/786,484
Granted
Oct 16, 2018
Kind
B2
Abstract

An object is to more accurately compare diagnosis indexes with each other, which are calculated from data obtained in different environments with a cardiac-function diagnostic medicine. A conversion function calculation unit acquires a first phantom Heart/Mediastinum ratio (H/M ratio) and a second phantom H/M ratio based on a phantom, the first phantom H/M ratio that is an H/M ratio of the phantom in the first imaging environment being acquired by performing, based on phantom data that is data of a first phantom image obtained by imaging the phantom in the first imaging environment and digital phantom data that is data of a digital phantom including a cardiac ROI and a mediastinum ROI, positioning of the digital phantom on the first phantom image, and by calculating based on the phantom data of the first phantom image to which the cardiac ROI and the mediastinum ROI are set; and obtains a conversion function based on the first phantom H/M ratio and the second phantom H/M ratio.

Claims (79)

1. A non-transitory computer-readable storage medium storing a program causing a computer to execute processing of:

positioning a digital phantom on a first phantom image based on phantom data that is data of the first phantom image obtained by imaging a phantom in a first imaging environment and digital phantom data that is data of the digital phantom including a cardiac ROI and a mediastinum ROI;

setting the cardiac ROI and the mediastinum ROI to the first phantom image on which the digital phantom is positioned;

calculating a first phantom Heart/Mediastinum ratio (H/M ratio) that is an H/M ratio of the phantom in the first imaging environment, based on the phantom data of the first phantom image to which the cardiac ROI and the mediastinum ROI are set;

acquiring a second phantom Heart/Mediastinum ratio (H/M ratio) based on the phantom; and

calculating a conversion function based on the first phantom H/M ratio and the second phantom H/M ratio.

2. The storage medium according to claim 1 , wherein

the second phantom H/M ratio that is an H/M ratio of the phantom in a second imaging environment is acquired by performing, based on phantom data that is data of a second phantom image obtained by imaging the phantom in the second environment and the digital phantom data, positioning of the digital phantom on the second phantom image, and by calculating based on the phantom data on the second phantom image to which the cardiac ROI and the mediastinum ROI are set; and

the conversion function is a function converting the first phantom H/M ratio into the second phantom H/M ratio.

3. The storage medium according to claim 2 , wherein

the first phantom H/M ratio is any one of an average value, a median value, and a mode value of a plurality of H/M ratios, corresponding to each imaging condition of the phantom in the first imaging environment, calculated based on a plurality of the first phantom images by capturing for a plurality of times an image of the phantom in the first imaging environment according to each imaging condition, and

the second phantom H/M ratio is any one of an average value, a median value, and a mode value of a plurality of H/M ratios, corresponding to each imaging condition of the phantom in the second imaging environment, calculated based on a plurality of the second phantom images by capturing for a plurality of times an image of the phantom in the second imaging environment according to each imaging condition.

4. The storage medium according to claim 2 , wherein

the conversion function includes:

a first conversion function converting the first phantom H/M ratio into an H/M ratio independent from the imaging environments; and

a second conversion function converting the H/M ratio independent from the imaging environments into the second phantom H/M ratio.

5. The storage medium according to claim 1 , wherein

the phantom data is data of the first phantom image obtained by imaging the phantom in a predetermined imaging condition of the first imaging environment,

the second phantom H/M ratio is an H/M ratio that is obtained under the predetermined imaging condition and is independent from the imaging environments, and

the conversion function is a function converting the first phantom H/M ratio into the H/M ratio independent from the imaging environments or converting the H/M ratio independent from the imaging environments into the first phantom H/M ratio.

6. The storage medium according to claim 5 , wherein the first phantom H/M ratio is any one of an average value, a median value, and a mode value of a plurality of H/M ratios, corresponding to each imaging condition of the phantom in the first imaging environment, calculated based on a plurality of the first phantom images by capturing for a plurality of times an image of the phantom in the first imaging environment in accordance with each imaging condition.

7. A non-transitory computer-readable storage medium storing a program causing a computer to execute processing of:

setting a cardiac ROI and a mediastinum ROI in a subject image obtained by imaging of a subject in a first imaging environment;

calculating an H/M ratio related to the subject based on the subject image to which the cardiac ROI and the mediastinum ROI are set;

acquiring a conversion function obtained based on a first phantom Heart/Mediastinum ratio (H/M ratio) and a second phantom H/M ratio based on a phantom, the first phantom H/M ratio that is an H/M ratio of the phantom in the first imaging environment being calculated based on phantom data of a first phantom image to which a cardiac ROI and a mediastinum ROI are set, with a digital phantom including the cardiac ROI and the mediastinum ROI being positioned on the first phantom image based on the phantom data that is data of the first phantom image obtained by imaging the phantom in the first imaging environment and digital phantom data that is data of the digital phantom; and

converting the H/M ratio related to the subject obtained from the first imaging environment into an H/M ratio of the second imaging environment by using the conversion function.

8. The storage medium according to claim 7 , wherein

the conversion function is a linear function with a slope, and the slope is any one of an average value, a median value, and a mode value of a plurality of the slopes as a result of obtaining the conversion function for a plurality of times.

9. The storage medium according to claim 7 , wherein

the second phantom H/M ratio is an H/M ratio of the phantom in a second imaging environment is acquired by performing, based on phantom data that is data of a second phantom image obtained by imaging the phantom in the second environment and the digital phantom data, positioning of the digital phantom on the second phantom image, and by calculating based on the phantom data on the second phantom image to which the cardiac ROI and the mediastinum ROI are set;

the conversion function is a function converting the first phantom H/M ratio into the second phantom H/M ratio; and

the H/M ratio related to the subject is an H/M ratio of the subject in the first imaging environment.

10. The storage medium according to claim 9 , wherein

the conversion function includes:

a first conversion function converting the first phantom H/M ratio into an H/M ratio independent from the imaging environments; and

a second conversion function converting the H/M ratio independent from the imaging environments into the second phantom H/M ratio.

11. The storage medium according to claim 7 , wherein

the phantom data is data on the first phantom image obtained by imaging the phantom in a predetermined imaging condition of the first imaging environment,

the second phantom H/M ratio is an H/M ratio that is obtained under the predetermined imaging condition and is independent from the imaging environments,

the conversion function is a function converting the first phantom H/M ratio into the H/M ratio independent from the imaging environments or converting the H/M ratio independent from the imaging environments into the first phantom H/M ratio, in use of the conversion function, the H/M ratio related to the subject is converted into the H/M ratio of the subject independent from the imaging environments, or the H/M ratio of the subject independent from the imaging environments is converted into the H/M ratio related to the subject, and

the H/M ratio related to the subject is an H/M ratio of the subject in the first imaging environment.

12. An information processing apparatus comprising:

a processor; and

a memory containing instructions that, when executed by the processor, cause the processor to:

position a digital phantom on a first phantom image based on phantom data that is data of the first phantom image obtained by imaging a phantom in a first imaging environment and digital phantom data that is data of the digital phantom including a cardiac ROI and a mediastinum ROI;

set the cardiac ROI and the mediastinum ROI to the first phantom image on which the digital phantom is positioned;

calculate a first phantom Heart/Mediastinum ratio (H/M ratio) that is an H/M ratio of the phantom in the first imaging environment, based on the phantom data of the first phantom image to which the cardiac ROI and the mediastinum ROI are set;

acquire a second phantom Heart/Mediastinum ratio (H/M ratio) based on the phantom; and

calculate a conversion function based on the first phantom H/M ratio and the second phantom H/M ratio.

13. The information processing apparatus according to claim 12 , wherein

the second phantom H/M ratio is an H/M ratio of the phantom in a second imaging environment is acquired by performing, based on phantom data that is data of a second phantom image obtained by imaging the phantom in the second environment and the digital phantom data, positioning of the digital phantom on the second phantom image, and by calculating based on the phantom data on the second phantom image to which the cardiac ROI and the mediastinum ROI are set; and

the conversion function is a function converting the first phantom H/M ratio into the second phantom H/M ratio.

14. The information processing apparatus according to claim 13 , wherein

the first phantom H/M ratio is any one of an average value, a median value, and a mode value of a plurality of H/M ratios, corresponding to each imaging condition of the phantom in the first imaging environment, calculated based on a plurality of the first phantom images by capturing for a plurality of times an image of the phantom in the first imaging environment according to each imaging condition, and

the second phantom H/M ratio is any one of an average value, a median value, and a mode value of a plurality of H/M ratios, corresponding to each imaging condition of the phantom in the second imaging environment, calculated based on a plurality of the second phantom images by capturing for a plurality of times an image of the phantom in the second imaging environment according to each imaging condition.

15. The information processing apparatus according to claim 12 , wherein

the phantom data is data on the first phantom image obtained by imaging the phantom in a predetermined imaging condition of the first imaging environment,

the second phantom H/M ratio is an H/M ratio that is obtained under the predetermined imaging condition and is independent from the imaging environments, and

the conversion function is a function with which conversion between the first phantom H/M ratio and the H/M ratio independent from the imaging environments is achievable.

16. The information processing apparatus according to claim 15 , wherein the first phantom H/M ratio is any one of an average value, a median value, and a mode value of a plurality of H/M ratios, corresponding to each imaging condition of the phantom in the first imaging environment calculated based on a plurality of the first phantom images by capturing for a plurality of times an image of the phantom in the first imaging environment in accordance with each imaging condition.

17. An information processing apparatus comprising:

a processor; and

a memory containing instructions that, when executed by the processor, cause the processor to:

set a cardiac ROI and a mediastinum ROI in a subject image obtained by imaging of a subject in a first imaging environment;

calculate an H/M ratio related to the subject based on the subject image to which the cardiac ROI and the mediastinum ROI are set;

acquire a conversion function obtained based on a first phantom Heart/Mediastinum ratio (H/M ratio) and a second phantom H/M ratio based on a phantom, the first phantom H/M ratio that is an H/M ratio of the phantom in the first imaging environment being calculated based on phantom data of a first phantom image to which a cardiac ROI and a mediastinum ROI are set, with a digital phantom including the cardiac ROI and the mediastinum ROI being positioned on the first phantom image based on the phantom data that is data of the first phantom image obtained by imaging the phantom in the first imaging environment and digital phantom data that is data of the digital phantom; and

convert the H/M ratio related to the subject obtained from the first imaging environment into an H/M ratio of the second imaging environment by using the conversion function.

18. The information processing apparatus according to claim 17 , wherein the conversion function is a linear function with a slope, and the slope is any one of an average value, a median value, and a mode value of a plurality of the slopes as a result of obtaining the conversion function for a plurality of times.

19. The information processing apparatus according to claim 17 , wherein

the second phantom H/M ratio is an H/M ratio of the phantom in a second imaging environment is acquired by performing, based on phantom data that is data of a second phantom image obtained by imaging the phantom in the second environment and the digital phantom data, positioning of the digital phantom on the second phantom image, and by calculating based on the phantom data on the second phantom image to which the cardiac ROI and the mediastinum ROI are set,

the conversion function is a function converting the first phantom H/M ratio into the second phantom H/M ratio, and

the H/M ratio related to the subject is an H/M ratio of the subject in the first imaging environment.

20. The information processing apparatus according to claim 17 , wherein

the phantom data is data on the first phantom image obtained by imaging the phantom in a predetermined imaging condition of the first imaging environment,

the second phantom H/M ratio is an H/M ratio that is obtained under the predetermined imaging condition and is independent from the imaging environments,

the conversion function is a function with which conversion between the first phantom H/M ratio and the H/M ratio independent from the imaging environments is achievable,

in use of the conversion function, the conversion unit converts the H/M ratio related to the subject into the H/M ratio of the subject independent from the imaging environments, or converts

the H/M ratio of the subject independent from the imaging environments into the H/M ratio related to the subject, and

the H/M ratio related to the subject is an H/M ratio of the subject in the first imaging environment.

Assignments (3)
CHANGE OF NAME Recorded Jun 28, 2022
From: FUJIFILM TOYAMA CHEMICAL CO., LTD.
To: PDRADIOPHARMA INC.
Reel/Frame 060448/0986 →
CHANGE OF NAME Recorded Feb 22, 2022
From: FUJIFILM RI PHARMA CO., LTD.
To: FUJIFILM TOYAMA CHEMICAL CO., LTD.
Reel/Frame 059069/0540 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 29, 2015
From: NAKAJIMA, KENICHI; OKUDA, KOICHI; HOSOYA, TETSUO; KIRIHARA, YUMIKO; ISHIKAWA, TAKEHIRO
To: FUJIFILM RI PHARMA CO., LTD.
Reel/Frame 036910/0477 →
Priority Claims (1)
JP 2013-094074 · Apr 26, 2013 · national
Continuity (1)
Related Publication 20160066878A1 · Mar 10, 2016