α7 nicotinic acetylcholine receptor modulators and uses thereof-III

1. A compound of Formula (Ib), or a pharmaceutically acceptable salt thereof:

wherein

R 1 is selected from pyridine or pyrimidine, each of which is substituted with one of F or CF 3 ;

R 2 is selected from hydrogen or C 1 -C 4 alkyl;

R 3 is C 1 -C 4 alkyl; and

R 4 ′ is selected from F, halo C 1 -C 4 alkyl or halo C 1 -C 6 alkoxy.

2. A compound of claim 1 , wherein R 2 is hydrogen or methyl.

3. A compound or a pharmaceutically acceptable salt thereof, which is:

4. A composition comprising a compound of claim 1 , or a pharmaceutically acceptable salt thereof and at least one pharmaceutically acceptable adjuvant, carrier or diluent.