Wound healing compositions including cyanoacrylate monomers and phenytoin
A monomeric adhesive composition includes a stabilized polymerizable monomer, such as a 1,1-disubstituted monomer, including a cyanoacrylate, and a wound healing agent, wherein the wound healing agent is 5,5-disubstitutedhydantoin, including phenytoin; and a method for making said composition.
1. A monomeric adhesive composition comprising: an alpha cyanoacrylate monomer, an amount of a free radical stabilizer and an anionic stabilizer effective to stabilize the alpha cyanoacrylate monomer, and 0.05% to 0.3% by weight of the composition of phenytoin; wherein the composition is a homogeneous mixture.
2. The monomeric adhesive composition of claim 1 , wherein the alpha cyanoacrylate monomer is selected from the group consisting of 2-octyl cyanoacrylate, n-butyl cyanoacrylate, and a mixture that is 80% by weight 2-octyl cyanoacrylate and 20% by weight n-butyl cyanoacrylate.
3. The composition of claim 1 , wherein the free radical stabilizer is butylated hydroxyl anisole.
4. The composition of claim 1 , wherein the anionic stabilizer is sulfur dioxide.
5. The composition of claim 2 , wherein the free radical stabilizer is butylated hydroxyl anisole.
6. The composition of claim 2 , wherein the anionic stabilizer is sulfur dioxide.
7. The monomeric adhesive composition of claim 1 , further comprising a plasticizing agent selected from the group consisting of tributyl citrate, diisodecyl adipate and acetyl tributyl citrate.
8. The monomeric adhesive composition of claim 1 , further comprising a thickening agent.
9. The monomeric adhesive composition of claim 2 , wherein the composition comprises 2-octyl cyanoacrylate monomer homogenously mixed together with 0.1% to 0.2% by weight of the composition of phenytoin.
10. The composition of claim 1 , wherein said composition is sterilized, and the viscosity of the sterilized composition increases between about 0% and about 40% after sterilization relative to the viscosity of the composition prior to sterilization.
11. The monomeric adhesive composition of claim 10 , wherein the composition is sterilized by irradiation.
12. The monomeric adhesive composition of claim 11 , wherein the composition is sterilized by E-beam irradiation.
13. The monomeric adhesive composition of claim 1 , wherein the composition comprises 0.1% to 0.2% by weight of the composition of phenytoin.
14. The monomeric adhesive composition of claim 1 , further comprising a polymerization accelerator.
15. The composition of claim 14 , wherein the polymerization accelerator comprises up to 2000 ppm of 18-crown-6 crown ether.
16. The composition of claim 2 , wherein said composition is sterilized, and the viscosity of the sterilized composition increases between about 0% and about 40% after sterilization relative to the viscosity of the composition prior to sterilization.
17. A method of treating tissue, comprising applying the adhesive composition of claim 1 to a tissue surface, and allowing said composition to polymerize on said tissue surface.
18. A kit, comprising an applicator and the composition of claim 1 .
19. A method of treating tissue, comprising applying the adhesive composition of claim 9 to a tissue surface, and allowing said composition to polymerize on said tissue surface.
20. A kit, comprising an applicator and the composition of claim 9 .