IP Library Granted Patent US 9,248,160
Granted Patent B1
US 9,248,160 · App. 14/811,264 · Granted Feb 2, 2016

Post-procedure skin care systems, compositions, and methods of use thereof

Inventors: Zein E. Obagi (Irvine, CA); Frederick W. Woodin, Jr. (Irvine, CA)
Assignee: ZO SKIN HEALTH, INC.
A61K38/168A61K31/19A61K31/722A61K33/06A61K45/06A61K47/36A61L15/18A61L15/20A61L15/28A61L15/32A61L15/44A61L2300/102A61L2300/21A61L2300/232A61L2300/252
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Quick Facts
Patent No.
US 9,248,160
App. No.
14/811,264
Granted
Feb 2, 2016
Kind
B1
Abstract

Provided are topical biocompatible compositions including a topical wound healing composition, a topical soothing composition and epidermal/dermal wound healing/repair composition. Also provided are methods of using the biocompatible compositions for treating and/or preventing comprimised, and methods for producing the biocompatible compositions.

Claims (34)

1. A topical wound healing composition, consisting essentially of:

aluminum sulfate tetradecahydrate present in an amount of from about 40.0 wt % to about 55.0 wt % based on the weight of the topical wound healing composition,

calcium acetate monohydrate present in an amount of from about 28.0 wt % to about 39.0 w t% based on the weight of the topical wound healing composition,

avena sativa kernel protein present in an amount of from about 0.01 wt % to about 20 wt % based on the weight of the topical wound healing composition,

soy protein in an amount of from about 0.01 wt % to about 20 wt % based on the weight of the topical wound healing composition, and

whey protein present in an amount of from about 0.01 wt % to about 20 wt % based on the weight of the topical wound healing composition;

chitosan present in an amount of from about 0.25 wt % to about 50 wt % based on the weight of the topical wound healing composition;

potassium sorbate present in an amount of from about 0.25 wt % to about 10 wt % based on the weight of the topical wound healing composition; and

dextrin present in an amount of from about 5 wt % to about 50 wt % based on the weight of the topical wound healing composition.

2. The wound healing composition of claim 1 , wherein the avena sativa kernel protein present in an amount of from about 1.5 wt % to about 4.5 wt % based on the weight of the wound healing compostion.

3. The wound healing composition of claim 1 , wherein the soy protein present in an amount of from about 0.5 wt % to about 2.5 wt % based on the weight of the the wound healing compostion.

4. The wound healing composition of claim 1 , wherein the whey protein present in an amount of from about 0.25 wt % to about 1.75 wt % based on the weight of the the wound healing compostion.

5. The wound healing composition of claim 1 , wherein the chitosan present in an amount of from about 0.25 wt % to about 1.75 wt % based on the weight of the the wound healing compostion.

6. A water-soluble, flowable powder, comprising the topical wound healing composition of claim 1 .

7. A solution, comprising the topical wound healing composition of claim 1 .

8. A topical dosage form selected from the group consisting of a cream, a lotion, an ointment, a foam, an aerosol, a powder, a solution, an emulsion, and a serum, comprising the wound healing compostion according to claim 1 .

9. The topical wound healing composition of claim 1 , wherein the topical wound healing composition does not comprise one or more of gluten, silica, an EU 26 fragrance allergen, a paraben, a formaldehyde releasing preservative, a growth factor or vitamin D.

10. A kit, comprising the topical wound healing composition of claim 1 .

11. A method for treating compromised skin in a subject, comprising:

topically administering to compromised skin of a subject in need thereof, a therapeutically effective amount of the topical wound healing composition according to claim 1 .

12. The method of claim 11 , wherein the topical wound healing composition is an aqueous solution.

13. The method of claim 12 , wherein administering comprises applying a compress comprising the solution, to the compromised skin of the subject.

14. The method of claim 11 , further comprising administering to the subject a topical soothing composition.

15. The method of claim 14 , wherein the topical soothing composition comprises one or more of a glycosaminoglycan (GAG) stimulator, an anti-inflammatory, an antioxidant, and/or a DNA repair component.

16. The method according to claim 11 , further comprising administering an epidermal/dermal repair composition.

17. The method of claim 16 , wherein the epidermal/dermal repair composition comprises one or more of a skin protectant, a peptide a moisturizer, an anti-inflammatory, an antioxidant, a carrier, a solvent, a thickening agent, a humectant, an emulsifier, anti-bacterial agents, anti-microbial agents, anti-fungal agents, an emollient, an emulsifiying agent, a skin protectant active, a neutralizing agent, a preservative, a collagen Stimulator, a DNA protector, a moisturizing agent, soy phospholipids, a DNA repairing agent and a skin conditioning agent.

18. The method of claim 17 , wherein the antioxidant is an antioxidant complex in the form of a 12-hour time release encapsulate.

19. A method for treating post-procedure skin in a subject following a skin procedure, comprising:

dissolving a topical wound healing composition according to claim 1 , in water to form a solution; and

topically administering a therapeutically effective amount of the solution to post-procedure skin of a subject in need thereof.

20. The method of claim 19 , wherein administering comprises applying a compress comprising the solution, to the post-procedure skin of the subject.

21. The method of claim 19 , wherein the pH of the solution is from 3.5 to 5.3.

22. The method of claim 20 , wherein the compress is a cloth or a gauze pad.

23. The method of claim 22 , wherein the compress comprising the solution is applied with pressure to sections of the post-procedure skin starting at day 1 post-procedure, every two to three hours during the day.

Assignments (6)
RELEASE OF SECURITY INTEREST Recorded May 23, 2025
From: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
To: ZO SKIN HEALTH, INC.
Reel/Frame 071207/0957 →
SECURITY INTEREST Recorded May 22, 2025
From: ZO SKIN HEALTH, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 071202/0975 →
RELEASE OF SECURITY INTEREST Recorded Nov 6, 2020
From: BANK OF THE WEST
To: ZO SKIN HEALTH, INC.
Reel/Frame 054302/0916 →
NOTICE OF GRANT OF SECURITY INTEREST IN PATENTS Recorded Nov 3, 2020
From: ZO SKIN HEALTH, INC.
To: BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT
Reel/Frame 054282/0969 →
SECURITY INTEREST Recorded Jul 31, 2019
From: ZO SKIN HEALTH, INC.
To: BANK OF THE WEST, AS AGENT
Reel/Frame 049923/0062 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 28, 2015
From: OBAGI, ZEIN E., DR.; WOODIN, FREDERICK W., JR.
To: ZO SKIN HEALTH, INC.
Reel/Frame 036201/0762 →