IP Library Granted Patent US 9,936,897
Granted Patent B2
US 9,936,897 · App. 14/812,822 · Granted Apr 10, 2018

Breath end-tidal gas monitor

Inventors: Lee R. Carlson (Pleasanton, CA); Edward A. McClatchie (Orinda, CA); Joe Martinosky (Wildwood, MO); Ralph Walden (Granite City, IL); Elvir Causevic (San Francisco, CA)
Assignee: Capnia, Inc.
A61B5/097A61B5/08A61B5/082A61B5/083A61B5/087A61B5/0833A61B5/0836
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Quick Facts
Patent No.
US 9,936,897
App. No.
14/812,822
Granted
Apr 10, 2018
Kind
B2
Abstract

An improved apparatus and method for capturing and analyzing the end-tidal portion of an exhalation. The CO 2 level of air drawn into the system ( 10 ) is monitored to distinguish inhalation and exhalation of breath. Upon detection of a decrease in the CO 2 level in the air drawn into the system ( 10 ), indicating a transition between exhalation and inhalation a pair of flow selector valves ( 26, 28 ) are operated to capture the end-tidal volume of air drawn into the system ( 10 ) immediately prior to the detection of the decrease in the CO 2 level. Incoming air is diverted around the captured volume of air, and the CO 2 levels are continually monitored to ensure that the captured volume of air corresponds to the end-tidal portion of an exhalation. Once the captured volume of air is positively identified as the end-tidal portion of an exhalation, the captured volume is routed through a gas analyzer ( 44 ) for analysis of one or more predetermined gas levels.

Claims (7)

1. A breath gas analyzer system including: an air inlet configured to receive aspirated air from the respiratory system of a subject; a capnograph coupled to said air inlet, said capnograph adapted to identify a transition point between an exhalation and an inhalation of air in the respiratory system; a plurality of flow selector valves; a sample volume coupled to said capnograph, said sample volume configured to selectively isolate a sample of aspirated air using the plurality of flow selector valves, said plurality of flow selector valves configured to selectively control a flow of air between said air inlet, said capnograph, said sample volume, and said at least one gas analyzer; and at least one gas analyzer coupled to and downstream from, at least one of the plurality of flow selector valves, and configured to receive a sample of aspirated air from said sample volume; and wherein said at least one gas analyzer is further configured to measure at least one gas concentration in said sample of aspirated air.

2. The breath gas analyzer system of claim 1 further including a pump, said pump configured to draw said aspirated air through said air inlet, said capnograph, and into said sample volume; and wherein said pump is further configured to expel said sample of aspirated air from said sample volume, and through said at least one gas analyzer.

3. The breath gas analyzer system of claim 1 further including at least one exhaust port configured to discharge air; and an airflow bypass pathway configured to selectively route an airflow from said capnograph to said exhaust port, bypassing said sample volume.

4. A method for capturing and analyzing the end-tidal portion of an exhalation, including the steps of: drawing a flow of air from the respiratory system of patient; identifying a point of transition representative of a change from exhalation to inhalation in the breath of said patient; upon identification of said transition point, isolating a sample volume of said flow of air drawn prior to said transition point air using a plurality of flow selector valves configured to selectively control the flow of air between said sample volume, and at least one gas analyzer, wherein the gas analyzer is coupled to and downstream from, at least one of the plurality of flow selector valves; confirming said change from exhalation to inhalation in the breath of said patient; measuring, upon confirmation of said change from exhalation to inhalation in the breath of said patient, at least one gas level in said isolated sample volume using the gas analyzer.

5. The method of claim 4 for capturing and analyzing the end-tidal portion of an exhalation wherein the step of identifying a point of transition includes monitoring changes in a concentration of gas in of said flow of air to identify a point of transition.

6. The method of claim 5 for capturing and analyzing the end-tidal portion of an exhalation wherein the step of identifying a point of transition includes monitoring changes in a concentration of CO 2 in of said flow of air, said point of transition corresponding to a transition from an increasing CO 2 level to a decreasing CO 2 level in said flow of air.

7. The method of claim 4 for capturing and analyzing the end-tidal portion of an exhalation wherein said step of measuring includes measuring a CO concentration in said isolated sample volume.

Assignments (9)
SECURITY INTEREST Recorded Dec 17, 2024
From: SOLENO THERAPEUTICS, INC.; ESSENTIALIS, INC.
To: OXFORD FINANCE LLC, AS COLLATERAL AGENT
Reel/Frame 069613/0369 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 21, 2018
From: SOLENO THERAPEUTICS, INC.
To: CAPNIA, INC.
Reel/Frame 044993/0308 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2018
From: CARLSON, LEE R.; MCCLATCHIE, EDWARD A.
To: EVEREST BIOMEDICAL INSTRUMENTS CO.
Reel/Frame 044919/0252 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2018
From: CAUSEVIC, ELVIR
To: EVEREST BIOMEDICAL INSTRUMENTS CO.
Reel/Frame 044919/0255 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2018
From: EVEREST BIOMEDICAL INSTRUMENTS, CO.
To: STRYKER CORPORATION
Reel/Frame 044919/0265 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2018
From: BIOMEDICAL DRUG DEVELOPMENT INC.
To: CAPNIA, INC.
Reel/Frame 044919/0291 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2018
From: STRYKER CORPORATION; EVEREST BIOMEDICAL INSTRUMENTS COMPANY
To: BIOMEDICAL DRUG DEVELOPMENT INC.
Reel/Frame 045328/0933 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2018
From: MARTINOSKY, JOE; WALDEN, RALPH
To: EVEREST BIOMEDICAL INSTRUMENTS CO.
Reel/Frame 044919/0243 →
CHANGE OF NAME Recorded Nov 17, 2017
From: CAPNIA, INC.
To: SOLENO THERAPEUTICS, INC.
Reel/Frame 044784/0981 →
Continuity (3)
Division 13153169 · Jun 3, 2011
Division 10561561
Related Publication 20150327793A1 · Nov 19, 2015