Epoxyeicosatrienoic acid analogs and methods of making and using the same
Compounds and compositions comprising epoxyeicosatrienoic acid (EET) analogs that act as EET agonists and are useful as medications in the treatment of drug-induced nephrotoxicity, hypertension and other related conditions. Methods of making and using the compounds and compositions are further described.
1. A compound selected from the group consisting of
2. A composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
3. A method of reducing hypertension in a subject, comprising administering to a subject a therapeutically effective amount of a compound according to claim 1 , wherein hypertension in said subject is reduced.
4. A method of reducing nephrotoxicity in a subject, comprising administering to a subject a therapeutically effective amount of a compound according to claim 1 , wherein nephrotoxicity in said subject is reduced.
5. The method of claim 4 , wherein the nephrotoxicity is drug-induced.
6. The method of claim 4 , wherein the nephrotoxicity is cisplatin-induced.
7. A method of reducing cisplatin nephrotoxicity in a subject, comprising administering to a subject a therapeutically effective amount of a compound according to claim 1 , wherein cisplatin nephrotoxicity in said subject is reduced.