Substituted 1,2,3,4,6,8,12,12a-octahydro-1,4-methanodipyrido[1,2-a:1',2'-d]pyrazines and methods for treating viral infections
Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R 1 , X, W, Y 1 , Y 2 , Z 1 , and Z 4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
1. A compound which is:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising a compound which is:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.
3. A compound which is:
or a pharmaceutically acceptable salt thereof.
4. A pharmaceutical composition comprising a compound which is:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.