IP Library › Granted Patent US 9,403,856
Granted Patent B2
US 9,403,856 · App. 14/816,191 · Granted Aug 2, 2016

Bcl-2/Bcl-xL inhibitors and therapeutic methods using the same

Inventors: Shaomeng Wang (Saline, MI); Jianfang Chen (Ann Arvor, MI); Donna McEachern (Ann Arbor, MI); Longchuan Bai (Ann Arbor, MI); Liu Liu (Ann Arbor, MI); Duxin Sun (Ann Arbor, MI); Xiaoqin Li (Ann Arbor, MI); Angelo Aguilar (Ann Arbor, MI)
Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
C07F9/65583A61K31/675A61K33/30A61K45/06A61N5/10
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Quick Facts
Patent No.
US 9,403,856
App. No.
14/816,191
Granted
Aug 2, 2016
Kind
B2
Abstract

Inhibitors of Bcl-2/Bcl-xL and compositions containing the same are disclosed. Methods of using the Bcl-2/Bcl-xL inhibitors in the treatment of diseases and conditions wherein inhibition of Bcl-2/Bcl-xL provides a benefit, like cancers, also are disclosed.

Claims (2)

1. A compound selected from the group consisting of

2. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier or vehicle.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 3, 2015
From: WANG, SHAOMENG; CHEN, JIANFANG; MCEACHERN, DONNA; BAI, LONGCHUAN; LIU, LIU; SUN, DUXIN; LI, XIAOQIN; AGUILAR, ANGELO
To: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
Reel/Frame 036236/0001 →
Continuity (3)
Continuation 14155809 · Jan 15, 2014
Provisional Application 61753066 · Jan 16, 2013
Related Publication 20150336994A1 · Nov 26, 2015