System and method for characterizing circulatory blood flow
A computer-implemented method for characterizing circulatory blood volume is disclosed. The method has the steps of acquiring a biological signal that emulates the arterial pulse wave from a sensor. Two derived parameters, circulatory stress, which reflects a harmonic of heart rate, and circulatory blood flow, which reflects the amplitude of the unprocessed biological signal, are extrapolated from the biological signal, and are each compared to a threshold value and assessed to determine an adequacy of circulatory blood volume. In embodiments, the assessment of circulatory blood volume is used to manage a patient's cardiovascular autoregulatory function or the adequacy of transfer of fluids to and from the circulatory system, with the ultimate goal of achieving a circulatory blood volume that adequately supplies the demands of the patient's tissues and organs.
1. A method for characterizing a circulatory blood flow of a human body, the method comprising:
receiving, by a computing device, a time domain biological signal emulating an arterial pulse wave from a sensor associated with the human body of a patient;
performing frequency analysis of the time domain biological signal to determine at least one of a fundamental frequency and an integer harmonic of a heart rate from the time domain biological signal wherein each of the fundamental frequency and integer harmonic is characterized by a frequency amplitude;
calculating, by the computing device, at least one normalized parameter including calculating a percent difference of at least one of the frequency amplitudes of the at least one of a fundamental frequency and an integer harmonic from the at least one pre-determined parameter baseline;
comparing, by the computing device, the at least one normalized parameter to a predetermined threshold value;
characterizing the circulatory blood flow from the comparison of the at least one normalized parameter to the predetermined threshold value; and
providing an indication reflective of the circulatory blood flow and the changes in circulatory blood volume over contiguous time intervals to a person monitoring the patient's human body for the management of the cardiovascular function of the patient.
2. The method of claim 1 , further comprising calculating, by the computing device, the at least one pre-determined parameter baseline from a variance from a filtered and conditioned time domain biological signal.
3. The method of claim 2 , further comprising dividing, by the computing device, the filtered and conditioned time domain biological signal into a plurality of discrete time windows.
4. The method of claim 2 , wherein the filtered and conditioned time domain biological signal comprises an amplified signal or an inverted signal.
5. The method of claim 1 , further comprising applying, by the computing device, a continuous-time filter to at least a portion of the time domain biological signal.
6. The method of claim 5 , wherein the continuous-time filter comprises one or more of the following:
a Butterworth filter; a Chebyshev filter; a Bessel filter; an elliptical filter; a custom low pass filter; and a filter based on determining a moving average.
7. The method of claim 1 , wherein the sensor comprises one or more of the following:
a transmissive photo-optic sensor; a reflective photo-optic sensor; a pressure transducer; a tonometry device; a strain gauge; an ultrasound device; an electrical impedance device; and a radar device.
8. The method of claim 1 , wherein the predetermined threshold value is a clinically validated value from a specific patient population.
9. The method of claim 1 , wherein the predetermined threshold value is associated with a pre-symptomatic circulatory blood volume inadequacy condition.
10. The method of claim 1 , wherein the predetermined threshold value is associated with a symptomatic circulatory blood volume inadequacy condition.