Synthetic or recombinant fucosylated oligosaccarides for use in the treatment of infections
The present invention relates to synthetic fucosylated oligosaccharide for use in the treatment or prophylaxis of an infection with a Norwalk-like Virus or Rotavirus of a mam-mal, wherein the synthetic fucosylated oligosaccharide comprises a non-reducing end and an reducing end, wherein the reducing end comprises a first carbohydrate unit consisting of a galactose (Gal) linked via a β1-4 glycosidic bond to a glucose (Glc), and wherein the non-reducing end comprises a second carbohydrate unit linked via a β1-3 glycosidic bond to the first carbohydrate unit of the reducing end, and wherein the second carbohydrate unit comprises a) at least one or more of a fucose (Fucose) and a Galactose (Gal), and b) at least one or more of a N-acetylglucosamine (GlcNAc) or a N-acetylgalactosamine (GalNAc).
1. A fucosylated oligosaccharide for treating or inhibiting an Norwalk-like Virus or Rotavirus infection in a mammal, wherein the fucosylated oligosaccharide comprises a non-reducing end and a reducing end, wherein the reducing end comprises a first carbohydrate unit consisting of a galactose (Gal) linked via a β1-4 glycosidic bond to a glucose (Glc), and wherein the non-reducing end comprises a second carbohydrate unit linked via a β1-3 glycosidic bond to the first carbohydrate unit of the reducing end, and wherein the second carbohydrate unit comprises a) at least one or more of a fucose (Fuc) and a galactose (Gal), and b) at least one or more of a N-acetylglucosamine (GlcNAc) or a N-acetylgalactosamine (GalNAc), and wherein the second carbohydrate unit is:
GlcNAcα1-3 (Fucα1-2)Galβ1-3GlcNAc
Galβ1-3(Fucα1-2)Galβ1-3GlcNAc
or
Fucα1-2Galβ1-4GalNAc.
2. The fucosylated oligosaccharide of claim 1 , wherein the fucosylated oligosaccharide is:
GlcNAcα1-3 (Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glc.
3. The fucosylated oligosaccharide of claim 1 , wherein the fucosylated oligosaccharide is Galβ1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glc.
4. The fucosylated oligosaccharide of claim 1 , wherein the fucosylated oligosaccharide is Fucα1-2Galβ1-4GalNAcβ1-3Galβ1-4Glc.
5. A composition comprising two or more of:
GlcNAcα1-3 (Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glc;
Galβ1-3(Fucα1-2)Galβ1-3GlcNAcβ1-3Galβ1-4Glc; and
Fucα1-2Galβ1-4GalNAcβ1-3Galβ1-4Glc.
6. A composition comprising the fucosylated oligosaccharide of claim 1 , and one or both of Fucα1-2Galβ1-3GlcNAcβ1-3Galβ1-4Glc and Galβ1-4(Fucα1-3)GlcNAcβ1-3Galβ1-4Glc.
7. A pharmaceutical composition comprising at least one of the fucosylated oligosaccharides of claim 1 , and a pharmaceutically acceptable carrier.
8. A synthetic nutrition composition comprising at least one of the fucosylated oligosaccharides of claim 1 .
9. A method for treating a Norwalk-like Virus infection in a mammal, comprising administering a therapeutically effective amount of the fucosylated oligosaccharide of claim 1 to the mammal, thereby treating the Norwalk-like virus infection in the mammal.
10. A method for treating a Norwalk-like Virus infection in a mammal, comprising administering a therapeutically effective amount of the fucosylated oligosaccharide of claim 2 to the mammal, thereby treating the Norwalk-like virus infection in the mammal.
11. A method for treating a Norwalk-like Virus infection in a mammal, comprising administering a therapeutically effective amount of the fucosylated oligosaccharide of claim 3 to the mammal, thereby treating the Norwalk-like virus infection in the mammal.
12. A method for treating a Norwalk-like Virus infection in a mammal, comprising administering a therapeutically effective amount of the fucosylated oligosaccharide of claim 4 to the mammal, thereby treating the Norwalk-like virus infection in the mammal.
13. A method for treating a Norwalk-like Virus infection in a mammal, comprising administering a therapeutically effective amount of the composition of claim 5 to the mammal, thereby treating the Norwalk-like virus infection in the mammal.
14. A method for treating a Norwalk-like Virus infection in a mammal, comprising administering a therapeutically effective amount of the pharmaceutical composition of claim 7 to the mammal, thereby treating the Norwalk-like virus infection in the mammal.
15. A method for treating a Norwalk-like Virus infection in a mammal, comprising administering a therapeutically effective amount of the synthetic nutrition composition of claim 8 to the mammal, thereby treating the Norwalk-like virus infection in the mammal.