IP Library Patent Application 14832030
Patent Application
App. No. 14/832,030

SYNTHESIS AND NOVEL SALT FORMS OF (R)-5-((E)-2-PYRROLIDIN-3YLVINYL)PYRIMIDINE

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Patent No.
US None
App. No.
14/832,030
Abstract

The present invention relates to the stereospecific synthesis of (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine, its salt forms, and novel polymorphic forms of these salts.

Claims (2)

1 . A product (R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine mono-citrate formed by a method through the intermediacy of tert-butyl(R)-3-vinylpyrrolidine-1-carboxylate.

2 . The product of claim 1 , wherein the tert-butyl(R)-3-vinylpyrrolidine-1-carboxylate is formed through the intermediacy of one or more of diethyl(R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)malonate, (R)-2-(1-(tert-butoxycarbonyl)pyrrolidin-3-yl)malonic acid, tert-butyl(R)-3-(2-hydroxyethyl)pyrrolidine-1-carboxylate, and tert-butyl(R)-3-(2-iodoethyl)pyrrolidine-1-carboxylate.

Assignments (4)
CORRECTIVE ASSIGNMENT TO CORRECT THE THE CONVEYING PARTY EXECUTION DATE PREVIOUSLY RECORDED AT REEL: 041044 FRAME: 0211. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Oct 26, 2021
From: TARGACEPT, INC.
To: CATALYST BIOSCIENCES, INC.
Reel/Frame 057923/0518 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 13, 2017
From: CATALYST BIOSCIENCES, INC.
To: OYSTER POINT PHARMA, INC.
Reel/Frame 041043/0769 →
CHANGE OF NAME Recorded Jan 13, 2017
From: TARGACEPT, INC.
To: CATALYST BIOSCIENCES, INC.
Reel/Frame 041044/0211 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 9, 2017
From: AKIREDDY, SRINIVASA RAO; BHATTI, BALWINDER SINGH; CUTHBERTSON, TIMOTHY J.; DULL, GARY MAURICE; MILLER, CRAIG HARRISON; MITCHENER, JOSEPH PIKE, JR; MUNOZ, JULIO A.; OTTEN, PIETER ALBERT
To: TARGACEPT, INC.
Reel/Frame 040904/0482 →