Methods and devices for using isoperillyl alcohol
The present invention provides for a method of treating a disease such as cancer, comprising the step of administering to a patient a therapeutically effective amount of an isomer or analog of monoterpene or sesquiterpene (or its derivative), such as an isoperillyl alcohol. The present invention also provides for a method of treating a disease comprising the step of administering to a patient a therapeutically effective amount of a derivative of an isomer or analog of monoterpene or sesquiterpene, such as an isoperillyl alcohol carbamate. The derivative may be an isoperillyl alcohol conjugated with a therapeutic agent such as a chemotherapeutic agent. The route of administration may vary, including inhalation, intranasal, oral, transdermal, intravenous, subcutaneous or intramuscular injection.
1. A pharmaceutical composition comprising an isoperillyl alcohol carbamate, wherein the isoperillyl alcohol carbamate is an isoperrilyl alcohol covalently bound via a carbamate linking group to temozolomide (TMZ).
2. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is administered by inhalation, intranasally, orally, intravenously, subcutaneously or intramuscularly.
3. The pharmaceutical composition of claim 1 , wherein the pharmaceutical composition is admixed or coformulated with a therapeutic agent.
4. The pharmaceutical composition of claim 1 , wherein the isoperillyl alcohol is selected from the group consisting of (4-isopropylidene cyclohex-1-enyl)methanol, (4-isopropyl cyclohexa-1,3-dienyl)methanol, (4-isopropyl cyclohexa-1,4-dienyl)methanol, (4-isopropylphenyl)methanol and (4-isopropenylphenyl)methanol.
5. The pharmaceutical composition of claim 1 , wherein the isoperillyl alcohol is 4-isopropylidene cyclohex-1-enyl)methanol.
6. A method for treating glioblastoma in a mammal, comprising the step of administering to the mammal the pharmaceutical composition of claim 1 .
7. The method of claim 6 , further comprising the step of treating the mammal with radiation.
8. The method of claim 6 , further comprising the step of administering to the mammal a chemotherapeutic agent.
9. The method of claim 6 , wherein the pharmaceutical composition is administered by inhalation, intranasally, orally, intravenously, subcutaneously or intramuscularly.