Compounds for use in treatment of mucostis
The present invention provides methods for treating and/or preventing mucostitis with one or more compounds, or pharmaceutically acceptable salts thereof, disclosed herein, or compositions comprising the same.
1. A method of treating mucositis in a mammal comprising administering to the mammal in need thereof a therapeutically effective amount of a compound having the formula
or a pharmaceutically acceptable salt thereof.
2. The method of claim 1 wherein the mammal is a human.
3. The method of claim 1 wherein the compound, or pharmaceutically acceptable salt thereof, administered to the mammal is present in a pharmaceutical composition.
4. The method of claim 3 wherein the pharmaceutical composition further comprises another therapeutic agent.
5. The method of claim 4 wherein the another therapeutic agent is palifermin.
6. The method of claim 1 wherein the mammal also receives chemotherapy, radiation therapy, or both.
7. The method of claim 1 wherein the compound is administered orally, bucally, or sublingually.
8. The method of claim 3 wherein the pharmaceutical composition is a liquid.
9. The method of claim 3 wherein the pharmaceutical composition is a rinse.
10. The method of claim 9 wherein the compound in the rinse is at 1 mg/ml, 3 mg/ml, or 10 mg/ml.
11. The method of claim 1 wherein the mammal also receives high-dose chemotherapy prior to hematopoietic cell transplantation, radiation therapy for tumors of the head and neck, induction therapy for leukemia, or conditioning regimens for bone marrow transplant.
12. A method of treating mucositis in a human comprising administering orally, bucally, or sublingually to the human in need thereof a liquid pharmaceutical composition in the form of a rinse comprising a compound having the formula
or a pharmaceutically acceptable salt thereof.
13. The method of claim 12 wherein the compound in the rinse is at 1 mg/ml, 3 mg/ml, or 10 mg/ml.
14. The method of claim 12 wherein the rinse further comprises palifermin.
15. A composition comprising
or a pharmaceutically acceptable salt thereof, and palifermin.