Composition and method for prevention, mitigation or treatment of an enteropathogenic bacterial infection
Bicyclic compounds for decreasing the expression of bacterial virulence factors thereby preventing, mitigating, or treating bacterial infection are provided.
1. A compound or a hydrate, isomer or pharmaceutically acceptable salt thereof having the structure:
wherein
R1 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkenyl;
R2 is H, alkenyl, or oxo;
n is 1-6;
and dashed lines a-e represent bonds that are independently present or absent and wherein dashed lines a-e are all present or all absent or dashed lines a, b and c are present and e and d are absent.
2. A pharmaceutical composition comprising the compound of claim 1 in admixture with a carrier.
3. The compound of claim 1 , wherein R 1 is C 1 -C 6 alkyl.
4. The compound of claim 1 , wherein R 1 is methyl.
5. The compound of claim 1 , wherein R 2 is hydrogen.
6. The compound of claim 1 , wherein n is 1, 2, 3, 4 or 5.
7. The compound of claim 1 , wherein n is 3, 4 or 5.
8. A compound selected from the group consisting of:
and pharmaceutically acceptable salts thereof.
9. The compound of claim 1 having the structure:
or a pharmaceutically acceptable salt thereof.