T cell balance gene expression, compositions of matters and methods of use thereof
This invention relates generally to compositions and methods for identifying the regulatory network that modulates, controls or otherwise influences T cell balance, for example, Th17 cell differentiation, maintenance and/or function, as well compositions and methods for exploiting the regulatory network that modulates, controls or otherwise influences T cell balance in a variety of therapeutic and/or diagnostic indications. This invention also relates generally to identifying and exploiting target genes and/or target gene products that modulate, control or otherwise influence T cell balance in a variety of therapeutic and/or diagnostic indications.
1. A method for increasing a non-pathogenic phenotype and/or decreasing a pathogenic phenotype in a Th17 cell or a population of Th-17 cells comprising:
delivering to a Th-17 cell, or a population of Th-17 cells, a vector comprising a nucleotide sequence encoding PROCR and configured to express PROCR, thereby increasing a non-pathogenic Th17 phenotype and/or decreasing a pathogenic phenotype in the Th17 cell or population of Th17 cells.
2. The method of claim 1 , wherein the Th17 cell or population of Th17 cells comprise a pathogenic Th17 cell or pathogenic population of Th17 cells.
3. The method of claim 1 , wherein the vector is delivered in vitro.
4. The method of claim 1 , wherein the vector is a retroviral vector.