Implant device
The invention provides chip packaging and processes for the assembly of retinal prosthesis devices. Advantageously, photo-patternable adhesive or epoxy such as photoresist is used as glue to attach a chip to the targeted thin-film (e.g., parylene) substrate so that the chip is used as an attachment to prevent delamination.
1. A biocompatible flexible thin-film substrate for attachment of a device, which is an integrated circuit (IC) chip, the flexible thin-film substrate comprising:
a first thin-film layer, which is made of parylene or a polymer;
a metal adjacent to the first thin-film layer;
a second thin-film layer made of parylene or a polymer adjacent to the metal to form a thin-film metal thin-film sandwich, wherein said second layer of thin-film has an opening, said opening having at least one electrical contact provided on an internal surface thereof, said opening configured to accept at least one electrical circuit device, which is an integrated circuit (IC) chip and to provide electrical communication between said at least one electrical contact and said at least one electrical circuit device, which is an integrated circuit (IC) chip, said biocompatible thin-film substrate configured to be implanted within a living organism after accepting said at least one electrical circuit device.
2. The biocompatible substrate of claim 1 , wherein the substrate is a parylene substrate.
3. The biocompatible substrate of claim 2 , wherein the first thin-film layer and the second thin-film layer are each independently selected from the group consisting of parylene, polyimide, Teflon, or Kapton.
4. The biocompatible substrate of claim 3 , wherein the first thin-film layer and the second thin-film layer are each parylene.
5. The biocompatible substrate of claim 2 , wherein the parylene substrate is first treated with oxygen plasma to enhancing bonding.
6. The biocompatible substrate of claim 1 wherein the device is integrated in the substrate by a conductive epoxy squeegee electrical connection.
7. The biocompatible substrate of claim 1 wherein the device is integrated into the substrate by a photo-patternable adhesive used as a mechanical glue.
8. The biocompatible substrate of claim 7 , wherein the photo-patternable adhesive or epoxy is photoresist.
9. The biocompatible parylene substrate of claim 8 , wherein the photoresist is a member selected from the group consisting of SU-8, AZ4620, AZ1518, AZ4400, AZ9260, THB-126N, WPR-5100, BCB, and polyimide.
10. The biocompatible substrate of claim 1 , wherein the first layer has a thickness of between about 0.1 μm to about 100 μm thick.
11. The biocompatible substrate of claim 1 , wherein the second layer is between 10 μm and 200 μm thick.
12. The biocompatible substrate of claim 1 , wherein said parylene is a member selected from the group consisting of parylene N, C, D, HT, AM, A or combinations thereof can also be used.
13. The biocompatible substrate of claim 12 , wherein said parylene is parylene-C.
14. The biocompatible substrate of claim 1 , wherein said metal is a metal alloy.
15. The biocompatible substrate of claim 14 , wherein said metal alloy is a member selected from the group consisting of Cr/Au, Ni/Au, Ti/Au, Al/Ti, Ag/Ti, Cr/Au/Ti/Ni/Au, Ni/Pd/Au, Ti/Ni/Au and combinations thereof.
16. The biocompatible substrate of claim 15 , wherein said metal alloy is a member selected from the group consisting of Cr/Au, Ni/Au, Ti/Au, Al/Ti, Ag/Ti, Cr/Au/Ti/Ni/Au, Ni/Pd/Au, Ti/Ni/Au and combinations thereof.
17. The biocompatible substrate of claim 15 , wherein said metal alloy is Ti/Au.