Methods of use of cyclopamine analogs
The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
1. A method for treating cancer in a subject, the method comprising administering to the subject a composition comprising a compound having the structure:
or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or diluent.
2. The method of claim 1 , wherein the compound is in the form of a pharmaceutically acceptable salt.
3. The method of claim 2 , wherein the salt is an acid salt.
4. The method of claim 3 , wherein the salt is an inorganic acid salt.
5. The method of claim 3 , wherein the salt is a hydrochloric acid salt.
6. The method of claim 1 , wherein the composition is a liquid composition.
7. The method of claim 1 , wherein the cancer is a cancer of the skin.
8. The method of claim 7 , wherein the composition is in the form of a cream, ointment, or spray.
9. The method of claim 7 , wherein the cancer is selected from the group consisting of squamous cell carcinoma, basal cell carcinoma, and melanoma.
10. The method of claim 9 , wherein the cancer is basal cell carcinoma.
11. The method of claim 7 , wherein the composition is administered topically.
12. The method of claim 1 , wherein said administering is carried out in combination with an additional cancer treatment.
13. The method of claim 12 , wherein said additional cancer treatment comprises radiation, surgery, or administration of a second chemotherapeutic agent.