Device and method for delivering medicaments

1. A delivery device for providing radiation treatment, the delivery device comprising a reversibly deformable substrate coupled to a flexible scaffold, wherein the reversibly deformable substrate is positioned between the flexible scaffold; and

a plurality of radioactive seeds removable from the reversibly deformable substrate in situ;

wherein the scaffold, the reversibly deformable substrate and the plurality of radioactive seeds are positionable within a void in a patient's body,

wherein the plurality of radioactive seeds are configured to be replaced in situ while the scaffold and the substrate remain in the void, and

wherein at least a portion of the radioactive seeds are supported on an outer surface of the substrate.

2. The device as recited in claim 1 , wherein the radioactive seeds are surrounded by the substrate.

3. The device as recited in claim 1 , wherein the substrate is configured to anatomically replicate an excised cancer bed of a patient.

4. The device as recited in claim 3 , wherein the substrate is adapted to expand to fill the void defining the cancer bed.

5. The device as recited in claim 4 , wherein the substrate is adapted to expand when manipulated from outside of the patient.

6. The device as recited in claim 4 , further comprising a plurality of delivery devices, wherein each device comprises a reversibly deformable substrate adapted to support a plurality of radioactive seeds, and wherein the plurality of devices are configured to reside in the void.

7. A medical device for providing radiation treatment, the medical device comprising:

a flexible scaffold;

a plurality of radioactive seeds;

a reversibly deformable substrate positioned between the flexible scaffold, wherein the substrate is designed to removably receive the radioactive seeds for placement within a void in a patient's body; and

at least one spacer positioned adjacent the plurality of radioactive seeds;

wherein the plurality of radioactive seeds are removable from the reversibly deformable substrate in situ while the scaffold and the substrate remain in the void, and

wherein at least a portion of the radioactive seeds are supported on an outer surface of the substrate.

8. The device as recited in claim 7 , wherein at least a portion of the reversibly deformable substrate surrounds the radioactive seeds.

9. The device as recited in claim 7 , wherein the substrate is configured to be manipulated from outside the patient.

10. The device as recited in claim 7 , wherein the reversibly deformable substrate is configured to expand and fill the void within the patient.

11. The device as recited in claim 7 , further comprising means for monitoring a movement of the reversibly deformable substrate within the void over time.

12. A radiation delivery device, comprising:

a flexible scaffold;

a reversibly deformable substrate positioned between the flexible scaffold;

a plurality of radioactive seeds positioned in the reversibly deformable substrate;

wherein the reversibly deformable substrate and the scaffold are positionable within a void in a patient's body with the plurality of radioactive seeds positioned in the reversibly deformable substrate; and

a plurality of radiopaque markers dispersed along the reversibly deformable substrate;

wherein the plurality of radioactive seeds are removable from the reversibly deformable substrate in situ while the substrate remains in the void, and

wherein at least a portion of the radioactive seeds are supported on an outer surface of the substrate.

13. The device of claim 12 , further comprising at least one spacer, wherein the spacer is configured to link the plurality of seeds together.

14. The device as recited in claim 13 , wherein the at least one spacer includes at least one of the radiopaque markers.

15. The device as recited in claim 12 , wherein the markers are arranged within a single plane.

16. The device as recited in claim 12 , wherein the markers are arranged within multiple planes.

17. The device as recited in claim 12 , wherein the plurality of radiopaque markers are homogeneously dispersed throughout the reversibly deformable substrate.

18. The device as recited in claim 12 , wherein the plurality of radiopaque markers reside on an outside surface of the reversibly deformable substrate.