Treatments for lowering glucose levels using FGF binding protein 3
The invention relates to methods of lowering blood glucose levels in a subject, with the methods comprising administering fibroblast growth factor binding protein 3 (FGFBP3) or a variant thereof to a subject in need of having lower glucose levels.
1. A method of lowering blood glucose levels in a subject in need thereof, the method comprising administering fibroblast growth factor binding protein 3 (FGFBP3) to the subject in need of lowering blood glucose levels.
2. The method of claim 1 , wherein the subject has diabetes.
3. The method of claim 1 , wherein the subject is obese.
4. The method of claim 1 , wherein subject is hyperglycemic.
5. The method of claim 1 , wherein the subject has abnormal glycogen metabolism.
6. The method of claim 1 , wherein the FGFBP3 is administered as a complex with fibroblast growth factor 19 (FGF19).
7. The method of claim 6 , wherein the subject has diabetes.
8. The method of claim 6 , wherein the subject is obese.
9. The method of claim 6 , wherein the subject is hyperglycemic.
10. The method of claim 6 , wherein the subject has abnormal glycogen metabolism.
11. A method of treating diabetes in a subject in need of treatment thereof, the method comprising administering fibroblast growth factor binding protein 3 (FGFBP3) to the subject in need of treatment of diabetes.
12. The method of claim 11 , wherein the FGFBP3 is administered as a complex with fibroblast growth factor 19 (FGF19).
13. A method of treating hyperglycemia in a subject in need of treatment thereof, the method comprising administering fibroblast growth factor binding protein 3 (FGFBP3) to the subject in need of treatment of hyperglucemia.
14. The method of claim 13 , wherein the FGFBP3 is administered as a complex with fibroblast growth factor 19 (FGF19).
15. The method any of claims 1 - 5 or 6 - 14 , wherein hepatic triglyceride levels are not affected in the subject.