Differentially pumped dual linear quadrupole ion trap mass spectrometer
The present disclosure provides a new tandem mass spectrometer and methods of using the same for analyzing charged particles. The differentially pumped dual linear quadrupole ion trap mass spectrometer of the present disclose includes a combination of two linear quadrupole (LQIT) mass spectrometers with differentially pumped vacuum chambers.
1. A system comprising:
a first mass spectrometer comprising a first ion trap in a first vacuum chamber;
a second mass spectrometer comprising a second ion trap in a second vacuum chamber; and
a vacuum manifold operably connecting the first and second vacuum chambers such that charged particles travel from the first vacuum chamber into the second vacuum chamber.
2. The system according to claim 1 , wherein the vacuum manifold contacts the first mass spectrometer at a back portion and contacts the second mass spectrometer at a front portion.
3. The system according to claim 2 , wherein the second ion trap is a linear quadrupole ion trap.
4. The system according to claim 3 , wherein the first ion trap is a linear quadrupole ion trap.
5. The system according to claim 4 , further comprising:
a first multipole and a first lens operably associated with the first ion trap; and
a second multipole and a second lens operably associated with the second ion trap.
6. The system according to claim 5 , further comprising an ion introduction multipole positioned between the ionization source and the first multipole.
7. The system according to claim 5 , wherein the first lens is disposed linearly between the ion introduction multipole and the first multipole.
8. The system according to claim 5 , wherein the second lens is disposed linearly between the first linear quadrupole ion trap and the second multipole.
9. The system according to claim 5 , wherein the first ion trap, the vacuum manifold, and said second ion trap are arranged linearly.
10. The system according to claim 4 , wherein the first ion trap is arranged at an angle to the second ion trap.
11. The system according to claim 1 , wherein the vacuum manifold comprises a multipole.
12. The system according to claim 11 , wherein the multipole in the vacuum chamber is configured to allow ions to travel from the first mass spectrometer to the second mass spectrometer.
13. The system according to claim 1 , further comprising an ionization source operably associated with the first mass spectrometer.
14. The system according to claim 13 , wherein the ionization source is an atmospheric pressure ionization source.
15. The system according to claim 1 , wherein the first trap mass spectrometer is configured for performing a first gas phase ion reaction and the second mass spectrometer is configured for performing a second gas phase ion reaction.
16. The system according to claim 15 , wherein the first gas phase ion reaction and the second gas phase ion reaction are selected from the group consisting of collision activated dissociation reactions, ion-molecular interaction, ion-ion reactions, and photon-induced dissociation reactions.
17. The system according to claim 1 , wherein the system is configured to utilize a direct current power source.
18. The system according to claim 1 , further comprising an RF power amplifier.