Treating auto-immune and auto-inflammatory diseases
View Patent ↗The present invention relates to the formulations, methods and kits for reducing cytokine interleukin-17 (IL-17 or IL-17A) levels in both broncheoalveolar lavage fluid (BALF) and blood/serum and/or for the inhibition of p38 mitogen activating protein kinase (MAPK) activity involving the use of 17α-hydroxyprogesterone caproate (17-OHPC) or derivatives thereof. The formulation may be in the form of an inhalant containing effective amounts of 17-OHPC, and the formulation may be used in a method to treat IL-17 cytokine and/or p38 MAPK mediated auto-immune and auto-inflammatory diseases. Such diseases may include glucocorticoid (GC) insensitive related diseases or conditions. In alternate embodiment, the formulation may include the combined use of budesonide (BUD) with 17-OPHC.
1. A method for treating a disease selected from chronic obstructive pulmonary disease, oliterative bronchitis, or asthma with symptoms of reduced airflow to lungs due to smooth muscle hypercontractility and airway remodeling of a patient, said method comprising administering to said patient by inhalation a pharmaceutical composition comprising a first treatment agent comprising 17alpha-hydroxyprogesterone caproate (“17-OHPC”) in an amount of from 0.03 mg/L to 0.3 mg/L, a second treatment agent comprising budesonide (“BUD”) at 0.2 g/L, and a pharmaceutically acceptable carrier, wherein the disease is mediated by interleukin-17 (“IL-17”) and an IL-17 level is reduced in said patient after administration of the pharmaceutical composition compared to an IL-17 level in a patient having the disease and without administration of the pharmaceutical composition.
2. The method of claim 1 , wherein said disease comprises symptoms of glucocorticoid insensitivity.
3. The method of claim 1 , wherein the 17-OHPC is administered according to a dosing regimen selected from the group of an administration interval less than once per week, once weekly, or exceeding once per week.
4. The method of claim 1 , wherein said pharmaceutical composition is administered according to a dosing regimen selected from the group of an administration interval less than once per week, once weekly, or exceeding once per week.
5. A method for reducing IL-17 expression in a patient affected by a disease selected from chronic obstructive pulmonary disease, oliterative bronchitis, or asthma, comprising administering to said patient by inhalation a pharmaceutical composition comprising a first treatment agent comprising 17-OHPC in an amount of from 0.03 mg/L to 0.3 mg/L and a second treatment agent comprising BUD at 0.2 g/L.
6. The method of claim 5 , wherein the patient is affected by a condition comprising symptoms of glucocorticoid insensitivity that is associated with said disease.
7. The method of claim 5 , wherein the pharmaceutical composition further comprises 17alpha-hydroxyprogesterone acetate or 17-alpha hydroxyprogesterone valproate.
8. A method of treating a respiratory inflammatory disease selected from chronic obstructive pulmonary disease, oliterative bronchitis, or asthma that is mediated by IL-17 in a subject, wherein the respiratory inflammatory disease is characterized by a detectable clinical symptom or change in level of a biochemical marker with respect to the normal range of the marker, the method comprising:
administering to the subject by inhalation a pharmaceutical composition comprising a first treatment agent comprising 17-OHPC in an amount of from 0.03 mg/L to 0.3 mg/L and a second treatment agent comprising BUD at 0.2 g/L,
continuing said administration until there is a return of the marker level to a normal range or a desired change in the clinical symptom,
where the marker or the clinical symptom comprises:
a decrease in expression of IL-17 in combination with,
(a) p38 mitogen activated protein kinase activity,
(b) lung structure, or
(c) lung function;
wherein the decrease in expression of IL-17 is compared to an expression level of IL-17 from a subject without administration of the pharmaceutical composition.
9. The method of claim 8 , wherein the second treatment agent is administered before, coincident with, or after administration of the first treatment agent.
10. A method for treating a disease mediated by interleukin-17 (“IL-17”) selected from chronic obstructive pulmonary disease, oliterative bronchitis, or asthma in a patient in need thereof comprising administering to said patient by inhalation from 0.03 mg/L to 0.3 mg/L of 17alpha-hydroxyprogesterone caproate (“17-OHPC”) and 0.2 g/L budesonide (“BUD”), and wherein said treatment comprises a reduction in IL-17 level in said patient after the treatment.