Local topical administration formulations containing indoxacarb
The present invention provides formulations and methods useful in the control of ectoparasites on a domestic animal, using a formulation comprising Indoxacarb and a veterinarily acceptable carrier that is applied topically to 10% or less of the total surface area of a domestic animal. Other embodiments include these formulations also including one or more additional pesticides such as fipronil.
1. A local, topical, spot-on formulation for control of ectoparasites on a domestic animal comprising:
(a) an ectoparasitically effective amount of Indoxacarb, wherein the amount of Indoxacarb in said formulation is about 5% to about 50% by weight;
(b) an ectoparasitically effective amount of permethrin, wherein the amount of permethrin in said formulation is about 30% to about 75% by weight; and
(c) a veterinarily acceptable carrier comprising a solvent consisting of propylene glycol monomethyl ether; and
wherein said formulation is capable of diffusing over the body of said domestic animal when applied to a localized region having a surface area of less than or equal to 10% of the total surface area of said domestic animal.
2. The formulation of claim 1 , wherein said ectoparasite is an Arthropod.
3. The formulation of claim 2 , wherein said Arthropod is an Insecta.
4. The formulation of claim 3 , wherein said Insecta is a flea, fly, or louse.
5. The formulation of claim 2 , wherein said Arthropod is an Arachnida.
6. The formulation of claim 1 , wherein said veterinarily acceptable carrier further comprises one or more of a crystallization inhibitor, adjuvant, co-solvent, colorant, surfactant, spreading oil, antioxidant, light stabilizer or tackifier.
7. The formulation of claim 6 , wherein said crystallization inhibitor is triacetin.
8. The formulation of claim 6 , wherein said antioxidant is selected from the group consisting of butylhydroxyanisole, butylhydroxytoluene, ascorbic acid, sodium thiosulphate, sodium metabisulphite, potassium metabisulphite, propyl gallate, tocopherol and a mixture thereof.
9. The formulation of claim 8 , wherein said antioxidant is propyl gallate.
10. The formulation of claim 1 , wherein said domestic animal is a mammal.
11. The formulation of claim 10 , wherein said mammal is a canine.
12. The formulation of claim 1 , said formulation comprising, by weight
5-35% lndoxacarb;
30-75% permethrin; and
QS propylene glycol monomethyl ether.
13. The formulation of claim 12 , wherein said formulation further comprises propyl gallate.
14. A method for the control of ectoparasites on a domestic animal comprising topically applying to a localized region having a surface area of less than or equal to 10% of the total surface area of said domestic animal the formulation of claim 1 .
15. The method of claim 14 , wherein said localized region has a surface area less than or equal to 5% of the total surface area of said domestic animal.
16. The method of claim 14 , wherein said domestic animal is a canine and said localized region of said canine is less than 10 cm 2 .
17. The method of claim 14 , wherein said formulation maintains persistent efficacy on said domestic animal to the extent that no greater than 5% decrease in efficacy occurs within 1 month after application of said formulation.
18. The method of claim 14 , wherein said formulation maintains persistent efficacy on said domestic animal to the extent that no greater than 5% decrease in efficacy occurs after 1 aqueous solution washing of said domestic animal.
19. A method for the control of ectoparasites on a domestic animal comprising topically applying to a localized region having a surface area of less than or equal to 10% of the total surface area of said domestic animal the formulation of claim 12 .