IP Library › Patent Application 14863597
Patent Application
App. No. 14/863,597

ALBUMIN VARIANTS

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Quick Facts
Patent No.
US None
App. No.
14/863,597
Abstract

The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.

Claims (21)

1 . A variant of albumin comprising a substitution in a position corresponding to position 490 in the amino acid sequence of SEQ ID NO:2, wherein the substitution is selected from the group consisting of A490C,D,E,F,G,H,I,K,L,M,N,P,R,S,T,V,W, and Y, and wherein the variant has at least 90% sequence identity to the amino acid sequence of SEQ ID NO:2.

2 . The variant of claim 1 , wherein the variant has at least 98% sequence identity to the amino acid sequence of SEQ ID NO:2.

3 . The variant of claim 1 , wherein the variant consists of the amino acid sequence of SEQ ID NO:2 with a substitution at position 490.

4 . The variant of claim 1 , wherein the substitution is A490C.

5 . The variant of claim 1 , wherein the substitution is A490D.

6 . The variant of claim 1 , wherein the substitution is A490E.

7 . The variant of claim 1 , wherein the substitution is A490F.

8 . The variant of claim 1 , wherein the substitution is A490G.

9 . The variant of claim 1 , wherein the substitution is A490H.

10 . The variant of claim 1 , wherein the substitution is A490I.

11 . The variant of claim 1 , wherein the substitution is A490K.

12 . The variant of claim 1 , wherein the substitution is A490L.

13 . The variant of claim 1 , wherein the substitution is A490M.

14 . The variant of claim 1 , wherein the substitution is A490N.

15 . The variant of claim 1 , wherein the substitution is A490P.

16 . The variant of claim 1 , wherein the substitution is A490R.

17 . The variant of claim 1 , wherein the substitution is A490S.

18 . The variant of claim 1 , wherein the substitution is A490T.

19 . The variant of claim 1 , wherein the substitution is A490V.

20 . The variant of claim 1 , wherein the substitution is A490W.

21 . The variant of claim 1 , wherein the substitution is A490Y.

Assignments (1)
CHANGE OF NAME Recorded Jul 15, 2016
From: NOVOZYMES BIOPHARMA DK A/S
To: ALBUMEDIX A/S
Reel/Frame 039360/0793 →