IP Library › Patent Application 14863752
Patent Application
App. No. 14/863,752

ALBUMIN VARIANTS

Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US None
App. No.
14/863,752
Abstract

The present invention relates to variants of a parent albumin having altered plasma half-life compared with the parent albumin. The present invention also relates to fusion polypeptides and conjugates comprising said variant albumin.

Claims (21)

1 . A variant of albumin comprising a substitution in a position corresponding to position 540 in the amino acid sequence of SEQ ID NO:2, wherein the substitution is selected from the group consisting of T540A,C,D,E,F,G,H,I,L,M,N,P,Q,R,S,V,W, and Y, and wherein the variant has at least 90% sequence identity to the amino acid sequence of SEQ ID NO:2.

2 . The variant of claim 1 , wherein the variant has at least 98% sequence identity to the amino acid sequence of SEQ ID NO:2.

3 . The variant of claim 1 , wherein the variant consists of the amino acid sequence of SEQ ID NO:2 with a substitution at position 540.

4 . The variant of claim 1 , wherein the substitution is T540A.

5 . The variant of claim 1 , wherein the substitution is T540C.

6 . The variant of claim 1 , wherein the substitution is T540D.

7 . The variant of claim 1 , wherein the substitution is T540E.

8 . The variant of claim 1 , wherein the substitution is T540F.

9 . The variant of claim 1 , wherein the substitution is T540G.

10 . The variant of claim 1 , wherein the substitution is T540H.

11 . The variant of claim 1 , wherein the substitution is T540I.

12 . The variant of claim 1 , wherein the substitution is T540L.

13 . The variant of claim 1 , wherein the substitution is T540M.

14 . The variant of claim 1 , wherein the substitution is T540N.

15 . The variant of claim 1 , wherein the substitution is T540P.

16 . The variant of claim 1 , wherein the substitution is T540Q.

17 . The variant of claim 1 , wherein the substitution is T540R.

18 . The variant of claim 1 , wherein the substitution is T540S.

19 . The variant of claim 1 , wherein the substitution is T540V.

20 . The variant of claim 1 , wherein the substitution is T540W.

21 . The variant of claim 1 , wherein the substitution is T540Y.

Assignments (1)
CHANGE OF NAME Recorded Jul 15, 2016
From: NOVOZYMES BIOPHARMA DK A/S
To: ALBUMEDIX A/S
Reel/Frame 039360/0793 →